Development of non-transgenic vaccine virus by using codon usage frequency

Research Project

Project/Area Number	23657156
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Evolutionary biology
Research Institution	National Institute of Advanced Industrial Science and Technology
Principal Investigator	KAKIZAWA Shigeyuki 独立行政法人産業技術総合研究所, 生物プロセス研究部門, 主任研究員 (10588669)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	ウイルス / 植物 / コドン / コドン頻度 / 弱毒ウイルス / 実験室内進化
Research Abstract	Codon usage frequencies of several plant species were investigated, and it was found that codon usage frequencies are similar between the plant species. Several strategies were examined to make transgenic plants that express tRNA genes of rare frequency c

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