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Reactivation of latently infected virus as a novel non-invasive stress marker

Research Project

Project/Area Number 23657170
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied anthropology
Research InstitutionThe University of Tokyo

Principal Investigator

ISHIDA Takafumi  東京大学, 理学(系)研究科(研究院), 教授 (20184533)

Research Collaborator TADAKARA Gento  東京大学, 大学院・理学系研究科, 博士課程
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsストレス評価 / ウイルス / 非侵襲 / ストレスマーカー / 社会的ストレス / アミラーゼ / 潜伏ウイルス / 再活性化 / ストレス指標 / 人類 / 霊長類
Research Abstract

To search for novel non-invasive stress marker(s), reactivation of latently infected ubiquitous viruses and salivary alpha-amylase were monitored. The concentrations of salivary alpha-amylase among several animals such as elephants, chimpanzees, horses, were measurable with a simple machine produced for human amylase monitoring. Shedding pattern of the human gamma-herpesvirus (EBV) into saliva delayed the changes of alpha-amylase concentration; reactivation of EBV (or gamma-herpesvirus) is considered to be a medium-range stress marker.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2014 2013 2012 2011 Other

All Journal Article (24 results) (of which Peer Reviewed: 23 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Human papillomavirus genotype and cervical cancer in Northeast Thailand.2014

    • Author(s)
      Natphopsuk, S., Settheetham-Ishida, W., Pientong, C., Sinawat, S., Yuenyao, P. and Ishida, T.
    • Journal Title

      Asian Pacific Journal of Cancer Prevention

      Volume: 15

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypertension Susceptibility Gene Prevalence in the Pacific Islands and Associations with Hypertension in Melanesia2013

    • Author(s)
      Furusawa T
    • Journal Title

      Journal of Human Genetics

      Volume: (in press) Issue: 3 Pages: 142-149

    • DOI

      10.1038/jhg.2012.147

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extra-pair paternity confirmed in wild white-handed gibbons2013

    • Author(s)
      Barelli, C., Matsudaira, K., Wolf, T., Roos, C., Heistermann, M., Hodges, K., Ishida, T., Malaivijitnond, S. and Reichard, U.H
    • Journal Title

      American Journal of Primatology

      Volume: 75 Issue: 12 Pages: 1185-1195

    • DOI

      10.1002/ajp.22180

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of uncoupling protein 2 and 3 genes polymorphism and energy expenditure in obese Indonesian children2013

    • Author(s)
      Mexitalia, M., Yamauchi, T., Utari, A., Sjarif, D R., Subagio, H W., Soemantri, A. and Ishida, T
    • Journal Title

      Journal of Pediatric Endocrinology

      Volume: 26 Issue: 5-6 Pages: 441-447

    • DOI

      10.1515/jpem-2012-0311

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evidence for the introgression between Hylobates lar and H2013

    • Author(s)
      Matsudaira, K., Reichard, U., Malavijitnond, S. and Ishida, T
    • Journal Title

      pileatus in the wild. Primates

      Volume: 54 Issue: 1 Pages: 33-37

    • DOI

      10.1007/s10329-012-0323-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low prevalence of Toxoplasma gondii infection among women in Northeastern Thailand2013

    • Author(s)
      Sakae, C., Natphopsuk, S., Settheetham-Ishida, W. and Ishida, T
    • Journal Title

      Journal of Parasitology

      Volume: 99 Issue: 1 Pages: 172-173

    • DOI

      10.1645/ge-3222.1

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A "functional SNP upstream of the beta-2 adrenergic receptor gene (ADRE2)is associated with obesity in Oceanic populations2013

    • Author(s)
      Naka l
    • Journal Title

      International Journal of Obesity

      Volume: (in press) Issue: 9 Pages: 1204-1210

    • DOI

      10.1038/ijo.2012.206

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extra-pair paternity confirmed in wild white-handed gibbons.2013

    • Author(s)
      Barelli, C., Matsudaira, K., Wolf, T., Roos, C., Heistermann, M., Hodges, K., Ishida, T., Malaivijitnond, S. and Reichard, U.H.
    • Journal Title

      American Journal of Primatology

      Volume: 75 Pages: 1185-1195

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 民族疫学の現場から2013

    • Author(s)
      石田貴文
    • Journal Title

      遺伝

      Volume: 67

    • Related Report
      2012 Research-status Report
  • [Journal Article] Risk factors for cervical cancer in northeastern Thailand : detailed analyses for the sexual and smoking behaviors2012

    • Author(s)
      Natphopsuk, S., Settheetham-Ishida, W., Sinawat, S., Pientong, C., Yuenyao, P. and Ishida, T
    • Journal Title

      Asian Pacific J. Cancer Prev

      Volume: 13 Pages: 5489-5495

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates2012

    • Author(s)
      Ohtani, H., Naruse, T.K., Iwasaki, Y., Akari, H., Ishida, T., Matano, T. and Kimura, A
    • Journal Title

      Immunogenetics

      Volume: 64 Issue: 9 Pages: 669-678

    • DOI

      10.1007/s00251-012-0628-y

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] <i>DRD4</i> VNTR polymorphism in Oceanic populations2012

    • Author(s)
      Naka, I. et al.
    • Journal Title

      Anthropological Science

      Volume: 120 Issue: 2 Pages: 151-155

    • DOI

      10.1537/ase.110901

    • NAID

      10031057349

    • ISSN
      0918-7960, 1348-8570
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The unstable CCTG repeat responsible for myotonic dystrophy type 2 originates from an AluSx element insertion into an early primate genome2012

    • Author(s)
      Kurosaki, T., Ueda, S., Ishida, T., Abe, K., Ohno, K. and Matsuura, T
    • Journal Title

      PLos One

      Volume: 7 Issue: 6 Pages: e38379-e38379

    • DOI

      10.1371/journal.pone.0038379

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct evidence for Toxoplasma gondii infection in a wild Japanese serow (Capricornis crispus) from mainland Japan2012

    • Author(s)
      Sakae, C. and Ishida, T
    • Journal Title

      J. Parasitology

      Volume: 98 Issue: 1 Pages: 224-225

    • DOI

      10.1645/ge-2881.1

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] (2012) : Hepatitis E virus outbreak in monkey facility, Japan2012

    • Author(s)
      Yamamoto, H., Suzuki, J., Matsuda, A., Ishida, T., Ami, Y., Suzaki, Y., Adachi, I., Wakita, T., Takeda, N., Li, T.-C
    • Journal Title

      Emerging Infectious Diseases

      Volume: 18(12) Pages: 2032-2034

    • URL

      http://dx.doi.org/eid1812.120884

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis E outbreak in monkey facility, Japan2012

    • Author(s)
      Yamamoto, H. et al.
    • Journal Title

      Emerging Infectious Diseases

      Volume: 18 Pages: 2032-2034

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Individual Variation in Behavioural Reactions to Unfamiliar Conspecific Vocalisation and Hormonal Underpinnings in Male Chimpanzees2012

    • Author(s)
      Kutsukake, N et al.
    • Journal Title

      Ethology

      Volume: 118 Issue: 3 Pages: 269

    • DOI

      10.1111/j.1439-0310.2011.02009.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia2011

    • Author(s)
      Nakayama K, Yanagiswa Y, Ogawa A, Ishizuka Y, Munkhtulga L, Charupoonphol P, Supannnatas S, Kuartei S, Chimedregzen U, Koda Y, Ishida T, Kagawa Y, Iwamoto S
    • Journal Title

      J Hum Genet

      Volume: 56 Issue: 12 Pages: 828-833

    • DOI

      10.1038/jhg.2011.109

    • NAID

      10030661852

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic Risk of DNA Repair Gene Polymorphisms (XRCC1 and XRCC3) for High Risk Human Papillomavirus Negative Cervical Cancer in Northeast Thailand2011

    • Author(s)
      Settheetham-Ishida, W., Yuenyao, P., Natphopsuk, S., Settheetham, D. and Ishida, T
    • Journal Title

      Asian Pacific J. Cancer Prev

      Volume: 12 Pages: 963-966

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution of immunoglobulin superfamily genes in primates2011

    • Author(s)
      Ohtani, H., Nakajima, T., Akari, H., Ishida, T. and Kimura, A
    • Journal Title

      Immunogenetics

      Volume: 63 Issue: 7 Pages: 417-428

    • DOI

      10.1007/s00251-011-0519-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Serum Leptin Level and Body Mass Index in Melanesian and Micronesian Solomon Islanders : Focus on Genetic Factors and Urbanization2011

    • Author(s)
      Furusawa, et al.
    • Journal Title

      American Journal of Human Biology

      Volume: 23 Issue: 4 Pages: 435-444

    • DOI

      10.1002/ajhb.21124

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution of immunoglobulin superfamily genes in primates2011

    • Author(s)
      Ohtani, H. et al.
    • Journal Title

      Immunogenetics

      Volume: 63 Pages: 435-444

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic Risk of DNA Repair Gene Polymorphisms (XRCC1 and XRCC3) for High Risk Human Papillomavirus Negative Cervical Cancer in Northeast Thailand.2011

    • Author(s)
      Settheetham-Ishida, W. et al.
    • Journal Title

      Asian Pacific J. Cancer Prev.

      Volume: 12 Pages: 963-966

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human papillomavirus genotype and cervical cancer in Northeast Thailand

    • Author(s)
      Natphopsuk, S., Settheetham-Ishida, W.,Pientong,C., Sinawat, S., Yuenyao, P. and Ishida, T
    • Journal Title

      Asian Pacific Journal of Cancer Prevention

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Current advances in gibbon phylogeny2012

    • Author(s)
      Matsudaira, K. and Ishida, T
    • Organizer
      The 3rd International Symposium on Southeast Asian Primates Research : Diversity and Evolution of Asian Primates
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2012-08-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Stress and Immunity2011

    • Author(s)
      Ishida, T.
    • Organizer
      The 40th Annual Meeting of the Physiological Society of Thailand, International Conference
    • Place of Presentation
      Khon Kaen, Thailand
    • Year and Date
      2011-05-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Stress and immunity2011

    • Author(s)
      Ishida, T.
    • Organizer
      The 40th Annual Meeting of the Physiological Society of Thailand, International Conference(招待講演)
    • Place of Presentation
      Khon Kaen, Thailand
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.biol.s.u-tokyo.ac.jp/users/anthro/lab.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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