| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
Eukaryotic organisms commonly possess various cellular degradation systems, suggesting the importance of 'degradation'. However, there is limited information about roles of cellular degradation system for host infection strategies of phytopathogenic fungi. In this study, we aimed to reveal outlines of cellular degradation systems involved in the pathogens' infection strategies. As a result, we revealed that ATG11 is required for pathogenicity of anthracnose fungus Colletotrichum orbiculare, and also is involved in selective autophagic degradation of peroxisomes. We also suggested that non-selective autophagic degradation is required for pathogenicity of the pathogen. Furthermore, we have generated a set of transgenic C. orbiculare reporter lines to monitor the status of each degradation system, including the dynamics of P bodies involved in mRNA degradation, which will be applied for screening of chemicals that inhibit corresponding degradation systems of the pathogen.
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