| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
To elucidate functions of factors associated with virus-like particles (VLPs), which are used for host regulation by a parasitoid wasp Meteorus pulchricornis, mRNA repertoire of pupal venom gland that produces VLPs were comprehensively obtained. By utilizing RNA interference-based approaches, a series of knockdown wasps that produce VLPs deficient in specified factors were prepared. Through the functional analyses of these altered VLPs, two novel VLP constituents that share some physicochemical properties with each other were found to suppress immune responses of host hemocytes.
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