Toward a new drug resitance mechanism by excretion in insects
| Project/Area Number |
23658054
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied entomology
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| Research Institution | National Institute of Agrobiological Sciences |
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Principal Investigator |
NODA Hiroaki 独立行政法人農業生物資源研究所, 昆虫微生物機能研究ユニット, 研究専門員 (40343991)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Yukiko 農業生物資源研究所, 昆虫科学研究領域, 主任研究員 (80414944)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ABC トランスポーター / トビイロウンカ / 殺虫剤抵抗性 / 薬剤耐性 / ABCトランスポーター |
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| Research Abstract |
Multidrug resistance proteins (ABC transporters) are well known in mammals and bacteria. In insects, multidrug resistance proteins are not well characterized, although these proteins may be related to insecticide resistance in insect pests. ABC transporters that are involved in drug excretion were explored based on sequence similarity, and two candidate genes were cloned. An ABC transporter gene, whose expression was up-regulated upon the insecticide treatment, was also found by microarray analyses. These three ABC transporter genes were introduced into insect cell line (Sf9) and cytotoxicity assay is performing to know whether these genes work for drug excretion.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] KONAGAbase : a genomic and transcriptomic database for the diamondback moth, Plutella xylostella2013
Author(s)
Jouraku A, Yamamoto K, Kuwazaki S, Urio M, Suetsugu Y, Narukawa J, Miyamoto K, Kurita K, Kanamori H, Katayose Y, Matsumoto T, Noda H
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Journal Title
BMC Genomics
Volume: 14
Pages: 464-464
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[Journal Article] A single amino acid mutation in an ABC transporter gene causes resistance to Bt toxin Cry1Ab in the silkworm2012
Author(s)
Atsumi S, Miyamoto K, Yamamoto K, Narukawa J, Kawai S, Sezutsu H, Kobayashi I, Uchino K, Tamura T, Mita K, Kadono-Okuda K, Wada S, Kanda K, Goldsmith MR, Noda H
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Related Report
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[Presentation] Progress in genome sequencing of the brown planthopper, Nilaparvata lugens2012
Author(s)
Suetsugu Y, Daimon T, Jouraku A, Kobayashi T, Nakamura Y, Kuwazaki S, Tanaka Y, Tanaka H, Shiotsuki T, Shinoda T, Yamamoto K, Noda H
Organizer
Arthropod Genomics 2012
Place of Presentation
Kansas City, アメリカ合衆国
Related Report
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[Presentation] Imidacloprid resistance in the brown planthopper : Genes for nAChR subunits and P450 enzymes2012
Author(s)
Noda H, Nakamura Y, Kawai S, Koizumi Y, Suetsugu Y, Kozaki T, Daimon T, Shinoda T, Yamamoto K, Sanada S, Matsumura M, Nakahira K, Ozoe Y
Organizer
XXIV International Congress of Entomology
Place of Presentation
Daegu, 韓国
Related Report
Invited
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[Presentation] Progress in genome sequencing of the brown planthopper, Nilaparvata lugens.2012
Author(s)
Suetsugu Y, Daimon T, Jouraku A, Kobayashi T, Nakamura Y, Kuwazaki S, Tanaka Y, Tanaka H, Shiotsuki T, Shinoda T, Yamamoto K, Noda H
Organizer
Arthropod Genomics 2012
Place of Presentation
Kansas City, アメリカ合衆国
Related Report
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[Presentation] Imidacloprid resistance in the brown planthopper: Genes for nAChR subunits and P450 enzymes.2012
Author(s)
Noda H, Nakamura Y, Kawai S, Koizumi Y, Suetsugu Y, Kozaki T, Daimon T, Shinoda T, Yamamoto K, Sanada S, Matsumura M, Nakahira K, Ozoe Y
Organizer
XXIV International Congress of Entomology
Place of Presentation
Daegu, 韓国
Related Report
Invited
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