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Chemical genomics using yeast essential genes for identifying target molecules/pathways of bioactive compounds

Research Project

Project/Area Number 23658077
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied microbiology
Research InstitutionKyoto University

Principal Investigator

NISHIMURA Shinichi  京都大学, 大学院・薬学研究科, 助教 (30415260)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsケミカルゲノミクス / ケミカルジェネティクス / 生育必須遺伝子 / 化学遺伝学
Research Abstract

There have been reported many natural and synthetic bioactive compounds. However, it is usually not easy to identify their target molecules and/or target pathways. T o overcome this difficulty, we tried to construct a semi-genome wide screen system using yeast as a model system. We show that semi-genome wide system is effective for predicting the target pathway of a bioactive compound, while informatics analysis utilizing gene-gene network is indispensable for constructing a versatile prediction system.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2012 2011

All Presentation (7 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] 放線菌の複合培養によって得られる新規テトラヒドロキノリン誘導体に関する研究2012

    • Author(s)
      杉山龍介、西村慎一、森夕希子、尾仲宏康、掛谷秀昭.
    • Organizer
      日本ケミカルバイオロジー学会第7回年会
    • Place of Presentation
      京都市
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 放線菌が生産する新規テトラヒドロキノリン誘導体の単離・構造解析.2012

    • Author(s)
      杉山龍介, 西村慎一, 森夕希子, 尾仲宏康, 掛谷秀昭
    • Organizer
      日本薬学会第132 年会
    • Place of Presentation
      札幌市.
    • Year and Date
      2012-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 生体膜を解析する化学遺伝学2012

    • Author(s)
      西村慎一、掛谷秀昭
    • Organizer
      日本薬学会第132 年会シンポジウム-天然物化学の新しい潮流-
    • Place of Presentation
      札幌市
    • Year and Date
      2012-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 生体膜を解析する化学遺伝学.2012

    • Author(s)
      西村慎一,掛谷秀昭
    • Organizer
      日本薬学会第132年会シンポジウム -天然物化学の新しい潮流-(招待講演)
    • Place of Presentation
      北海道大学(北海道)
    • Related Report
      2011 Research-status Report
  • [Presentation] Marine natural products targeting cellular membrane.2011

    • Author(s)
      Nishimura, S.
    • Organizer
      7th U.S.-Japan Seminar on Marine Natural Products: Cross-Disciplinary Expansions in Marine Bioorganic Chemistry.
    • Place of Presentation
      Okinawa, Japan.
    • Year and Date
      2011-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 分裂酵母における細胞膜ステロールの局在制御の解析2011

    • Author(s)
      越智純子, 西村慎一, 掛谷秀昭.
    • Organizer
      酵母遺伝学フォーラム・第44回研究報告会
    • Place of Presentation
      福岡市
    • Year and Date
      2011-09-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Marine natural products targeting cellular membrane.2011

    • Author(s)
      Shinichi Nishimura
    • Organizer
      7th U.S.-Japan Seminar on Marine Natural Products: Cross-Discipllinary Expansions in Marine Bioorganic Chemistry(招待講演)
    • Place of Presentation
      沖縄コンベンションセンター(沖縄)
    • Related Report
      2011 Research-status Report
  • [Book] 細胞膜を撹乱する海洋天然物 -セオネラミドはステロールに結合し、異常な細胞壁合成を誘導する-.化学と生物. 492011

    • Author(s)
      西村慎一, 掛谷秀昭, 吉田稔
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 新規抗真菌剤2012

    • Inventor(s)
      掛谷秀昭、西村慎一、杉山龍介、尾仲宏康
    • Industrial Property Number
      2012-170361
    • Filing Date
      2012-07-31
    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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