Chemical genomics using yeast essential genes for identifying target molecules/pathways of bioactive compounds
| Project/Area Number |
23658077
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied microbiology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ケミカルゲノミクス / ケミカルジェネティクス / 生育必須遺伝子 / 化学遺伝学 |
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| Research Abstract |
There have been reported many natural and synthetic bioactive compounds. However, it is usually not easy to identify their target molecules and/or target pathways. T o overcome this difficulty, we tried to construct a semi-genome wide screen system using yeast as a model system. We show that semi-genome wide system is effective for predicting the target pathway of a bioactive compound, while informatics analysis utilizing gene-gene network is indispensable for constructing a versatile prediction system.
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Report
(3 results)
Research Products
(9 results)
