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Immune regulation systems in milk

Research Project

Project/Area Number 23658108
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionGunma University

Principal Investigator

ENOMOTO Atsushi  群馬大学, 理工学研究院, 准教授 (70183217)

Project Period (FY) 2011-04-28 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsミルク / ペプチド / T細胞 / 1型糖尿病 / 自己免疫疾患 / 鶏卵アレルギー / アレルギー疾患 / 免疫抑制剤 / 牛乳 / 1型糖尿病 / サイトカイン / 抗原提示細胞 / アレルギー / IL-10
Outline of Final Research Achievements

A milk peptide fraction newly purified from cow's milk was found to highly suppress both allergen- and autoantigen-specific murine T cell responses, independent of their antigen specificity and MHC restriction. Our findings may be useful for preventing the allergies and autoimmune diseases.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2013 2012 Other

All Presentation (6 results)

  • [Presentation] T細胞応答に及ぼすミルクペプチド画分の作用(I)2013

    • Author(s)
      真下和樹、八村敏志、川上 浩、榎本 淳
    • Organizer
      日本食品免疫学会第9回学術大会
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] T細胞応答に及ぼすミルクペプチド画分の作用(II)2013

    • Author(s)
      佐藤真名美、八村敏志、榎本 淳、川上 浩
    • Organizer
      日本食品免疫学会第9回学術大会
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラクトパーオキシダーゼのIL-10応答誘導効果を抑制するミルクペプチド画分2012

    • Author(s)
      中村圭介、八村敏志、川上浩、榎本淳
    • Organizer
      日本食品免疫学会2012年度大会
    • Place of Presentation
      ヤクルトホール(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] Interleukin-10-producing Regulatory Cells Induced by Cow’s Milk Lactoperoxidase.2012

    • Author(s)
      A. Enomoto, T. Takeuchi, K. Takahashi, M. Chibana, S. Hachimura and H. Kawakami
    • Organizer
      The 25th Annual and International Meeting of the Japanese Association for Animal Cell Technology
    • Place of Presentation
      Nagoya Congress Center, Nagoya
    • Related Report
      2012 Research-status Report
  • [Presentation] 自己抗原および牛乳ラクトパーオキシダーゼにより誘導されるIL-10産生細胞

    • Author(s)
      真下和樹、柏木春香、野澤清史、星野早苗、八村敏志、川上浩、榎本淳
    • Organizer
      日本動物細胞工学会2011年度大会
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 鶏卵アレルゲンに特異的な免疫応答に及ぼすラクトパーオキシダーゼの抑制効果

    • Author(s)
      生方孝明、八村敏志、川上浩、榎本淳
    • Organizer
      日本食品免疫学会2011年度大会
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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