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Rational design of mixing ratio of food-derived anti-inflammatory factors based on molecular mechanisms.

Research Project

Project/Area Number 23658119
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionFukui Prefectural University

Principal Investigator

OHIGASHI Hajime  福井県立大学, 生物資源学部, 特任教授 (80026583)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Masakazu  福井県立大学, 生物資源学部, 准教授 (80315837)
KAWABATA Kyuichi  福井県立大学, 生物資源学部, 助教 (60452645)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords食細胞 / マクロファージ / 抗炎症化合物 / 相乗作用 / NO産生抑制効果 / 抗炎症作用 / 分子作用機序
Research Abstract

From isobolograms of various food-derived NO production-suppressive compounds, Curcumin (CUR) and Resveratrol (RES) showed synergistic effects. While CUR and Luteolin (LUT) also showed synergistic effect, Chrysin (CHR) and Apigenin (API), other flavones with NO production-suppressive activity, did not show synergism with CUR. From Western blot analysis, combination of not only CUR and LUT but also CUR and RES showed enhancement effects in inhibitory rate of LPS-induced iNOS protein production. Because LUT has characteristic catechol moiety in the B-ring, which is not resided in CHR and API, the moiety may be associated in the synergism between LUT and CUR.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (52 results)

All 2013 2012 2011

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (36 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis.2013

    • Author(s)
      Murakami A.
    • Journal Title

      BioFactors

      Volume: 39 Issue: 2 Pages: 221-232

    • DOI

      10.1002/biof.1054

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Flavonols enhanced production of anti-inflammatory substans(s) by Bifidobacterium adolescentis: prebiotic actions of galangin, quercetin, and fisetin.2013

    • Author(s)
      Kawabata K, Sugiyama Y, Sakano T, Ohigashi H
    • Journal Title

      BioFactors

      Volume: (in press) Issue: 4 Pages: 422-429

    • DOI

      10.1002/biof.1081

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 福井県伝統野菜木田チリメンシソの抗アレルギー作用の検討2013

    • Author(s)
      高橋正和、橋本直哉、小林恭一、大東 肇
    • Journal Title

      福井県立大学論集

      Volume: 第40号 Pages: 83-87

    • NAID

      120005261529

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 福井県伝統野菜木田チリメンシソの抗アレルギー作用の検討2013

    • Author(s)
      高橋正和
    • Journal Title

      福井県立大学論集

      Volume: 40 Pages: 83-87

    • NAID

      120005261529

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells.2012

    • Author(s)
      Sawada K.
    • Journal Title

      Lipids Health Dis.

      Volume: 11 Issue: 1 Pages: 36-36

    • DOI

      10.1186/1476-511x-11-36

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Absorption and metabolism of 4-hydroxyderricin and xanthoangelol after oral administration of Angelica keiskei (Ashitaba) extract in mice.2012

    • Author(s)
      Nakamura T.
    • Journal Title

      Arch. Biochem. Biophys.

      Volume: 521 Issue: 1-2 Pages: 71-76

    • DOI

      10.1016/j.abb.2012.03.013

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of quercetin and its glucuronide metabolite upon 6-hydorxydopamine-induced oxidative damage in Neuro-2a cells.2012

    • Author(s)
      Mukai, R., Kawabata, K., Otsuka, S., Ishisaka, A., Kawai, Y., Ji, Z.S., Tsuboi, H., and Terao, J.
    • Journal Title

      Free Radical Research

      Volume: 46 Issue: 8 Pages: 1019-1028

    • DOI

      10.3109/10715762.2012.673720

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The electrolytic reduction of abscisic acid methyl ester and its free acid.2012

    • Author(s)
      N. Hirai
    • Journal Title

      Phytochemistry

      Volume: 80 Pages: 89-98

    • DOI

      10.1016/j.phytochem.2012.04.010

    • NAID

      120004873777

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 1,2-Di-O-.ALPHA.-linolenoyl-3-O-.BETA.-galactosyl-sn-glycerol as a Superoxide Generation Inhibitor from Perilla frutescens var. crispa2011

    • Author(s)
      Takahashi M., Sugiyama Y., Kawabata K., Takahashi Y., Irie K., Murakami A., Kubo, Y, Kobayashi K., and Ohigashi H.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 75 Issue: 11 Pages: 2240-2242

    • DOI

      10.1271/bbb.110414

    • NAID

      10030397123

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2.2011

    • Author(s)
      Shin J.W., Ohnishi K., Murakami A., Lee J.S., Kundu J.K., Na H.K., Ohigashi H., and Surh Y.J.
    • Journal Title

      Cancer Prev. Res.

      Volume: Vol.4, No.6 Issue: 6 Pages: 860-870

    • DOI

      10.1158/1940-6207.capr-10-0354

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 1,2-Di-O-alpha-linolenoyl-3-O-beta-galactosyl-sn-glycerol as a superoxide generation inhibitor from Perilla frutescens var. crispa.2011

    • Author(s)
      Takahashi M.., Sugiyama Y., Kawabata K., Takahashi Y., Irie K., Murakami A., Kubo Y., Kobayashi K., and Ohigashi H.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 75 Pages: 2240-2242

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf22011

    • Author(s)
      Shin J.W., Ohnishi K., Murakami A., Lee J.S., Kundu J.K., Na H.K., Ohigashi H., and Surh Y.J.
    • Journal Title

      Cancer Prev. Res.

      Volume: 4 Pages: 860-870

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 食による生活習慣病の予防:学術界のこれからの責務2011

    • Author(s)
      大東 肇
    • Journal Title

      日本予防医学会雑誌

      Volume: 6 Pages: 3-6

    • NAID

      40018812091

    • Related Report
      2011 Research-status Report
  • [Journal Article] がん予防と機能性食品2011

    • Author(s)
      大東 肇
    • Journal Title

      Functional Food

      Volume: 14 Pages: 316-320

    • Related Report
      2011 Research-status Report
  • [Presentation] マクロファージのNO産生における食由来化合物の相乗的抑制効果の解析2013

    • Author(s)
      新宅恵・市原叡・城戸口達也・吉田恭子・加納恭卓
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台市
    • Year and Date
      2013-03-27
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 亜鉛トランスポーターZIP4の発現を促進する大豆由来成分の単離・同定2013

    • Author(s)
      高橋正和、大倉克摩、橋本彩子、永尾雅哉、神戸大朋、入江一浩、大東 肇
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台市
    • Year and Date
      2013-03-27
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] ケルセチンによるビフィズス菌の抗炎症活性増強効果2013

    • Author(s)
      坂野太研、川畑球一,大東 肇
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台市
    • Year and Date
      2013-03-27
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Purification, identification, and seasonal quantification analyses of nitric oxide generation inhibitory compounds in Spinacia oleracea2012

    • Author(s)
      Takahashi M., Nakamura S., Sugiyama Y., Kubo Y., Kobayashi K., Murakami A., Irie K., Kawabata K., and Ohigashi H
    • Organizer
      International Society for Nutraceuticals & Functional Foods (ISNFF2012)2012 Annual Conference & Exhibition
    • Place of Presentation
      Kailua-Kona, USA
    • Year and Date
      2012-12-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Post-transcriptional suppression mechanisms of inducible nitric oxide synthase in RAW264 cells by 3-O-p-coumaroylalphitolic acid from Zizyphus jujuba2012

    • Author(s)
      Ohkura K., Sugiyama Y., Kawabata K., Takahashi M., and Ohigashi H
    • Organizer
      International Society for Nutraceuticals & Functional Foods (ISNFF2012)2012 Annual Conference & Exhibition
    • Place of Presentation
      Kailua-Kona, USA
    • Year and Date
      2012-12-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification and molecular analyses of galactoglycerolipids from edible plants as radical generation inhibitory compounds in activated phagocytes2012

    • Author(s)
      Takahashi M., Sugiyama Y., Nakamura S., Hashimoto N., Kubo Y., Kobayashi K., Kawabata K., and Ohigashi H
    • Organizer
      The 25th Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT2012)
    • Place of Presentation
      Nagoya
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 相乗作用を示す食素材由来NO産生抑制化合物の探索・評価2012

    • Author(s)
      上前知之、杉山友太、川畑球一、高橋正和、大東 肇
    • Organizer
      日本フードファクター学会(JSoFF)第17回JSoFF・第9回日本カテキン学会合同大会2012
    • Place of Presentation
      静岡市
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] フラボノールによるビィズス菌の抗炎症活性増強効果2012

    • Author(s)
      川畑球一、坂野太研、大東 肇
    • Organizer
      日本フードファクター学会(JSoFF)第17回JSoFF・第9回日本カテキン学会合同大会2012
    • Place of Presentation
      静岡市
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 食素材由来のNO産生抑制化合物における相乗作用に関する研究2012

    • Author(s)
      上前知之、杉山友太、川畑球一、高橋正和、大東 肇
    • Organizer
      日本農芸化学会中部支部第166回例会
    • Place of Presentation
      福井市
    • Year and Date
      2012-11-02
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 亜鉛トランスポーターZIP4の発現を促進する大豆由来成分の単離・解析2012

    • Author(s)
      大倉克摩、高橋正和、橋本彩子、永尾雅哉、神戸大朋、大東 肇
    • Organizer
      日本農芸化学会中部支部第165回例会
    • Place of Presentation
      名古屋市
    • Year and Date
      2012-10-27
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] ヒトが食べるくすり、チンパンジーがたべるくすり2012

    • Author(s)
      大東 肇
    • Organizer
      、杉山産業化学研究所第74回公開講演会
    • Place of Presentation
      藤沢市
    • Year and Date
      2012-05-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 木田チリメンシソ単離したガラクトグリセロ脂質は食細胞においてO2-およびNOの産生を阻害する2012

    • Author(s)
      高橋正和、杉山友太、高橋 有、川畑球一、村上 明、入江一浩、久保義人、小林恭一、大東 肇
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都市
    • Year and Date
      2012-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] クマリン類の抗炎症作用における分子機序の類似性とアルキルオキシ基の寄与2012

    • Author(s)
      川畑球一、奥村真由、宮下美希、杉山友太、高橋正和、大東 肇
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都市
    • Year and Date
      2012-03-24
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] 食細胞のラジカル産生を抑制する農作物由来化合物の研究2012

    • Author(s)
      高橋正和
    • Organizer
      RENA第50回定期セミナー
    • Place of Presentation
      つくば市
    • Year and Date
      2012-02-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 「ヒトが食べるくすり、チンパンジーがたべるくすり」2012

    • Author(s)
      大東 肇
    • Organizer
      (一般財団法人)杉山産業化学研究所・第74回公開講演会
    • Place of Presentation
      藤沢市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 亜鉛トランスポーターZIP4の発現を促進する食素材成分の単離・解析2012

    • Author(s)
      大倉克摩
    • Organizer
      トランスポーター研究会第7回年会 (JTRA2012)
    • Place of Presentation
      京都市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Paenibacillus属FPU-7株由来金属プロテアーゼNPR-7のプロ配列機能解析2012

    • Author(s)
      三浦優子
    • Organizer
      日本農芸化学会中部支部第166回例会
    • Place of Presentation
      福井市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大豆抽出物に含まれる亜鉛トランスポーター発現促進成分の単離・解析2012

    • Author(s)
      大倉克摩
    • Organizer
      北陸合同バイオシンポジウム
    • Place of Presentation
      あわら市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 相乗作用を示す食素材由来NO産生抑制化合物の探索・評価2012

    • Author(s)
      上前知之
    • Organizer
      第17回日本フードファクター学会(JSoFF)・第9回日本カテキン学会合同大会
    • Place of Presentation
      静岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] フラボノールによるビィズス菌の抗炎症活性増強効果2012

    • Author(s)
      川畑球一
    • Organizer
      第17回日本フードファクター学会(JSoFF)・第9回日本カテキン学会合同大会
    • Place of Presentation
      静岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification and molecular analyses of galactoglycerolipids from edible plants as radical generation inhibitory compounds in activated phagocytes.2012

    • Author(s)
      Takahashi M.
    • Organizer
      The 25th Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT2012)
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Purification, identification, and seasonal quantification analyses of nitric oxide generation inhibitory compounds in Spinacia oleracea.2012

    • Author(s)
      Takahashi M.
    • Organizer
      International Society for Nutraceuticals & Functional Foods 2012 Annual Conference & Exhibition(ISNFF2012)
    • Place of Presentation
      Kailua-Kona, Hawaii, U.S.A.
    • Related Report
      2012 Annual Research Report
  • [Presentation] Post-transcriptional suppression mechanisms of inducible nitric oxide synthase in RAW264 cells by 3-O-p-coumaroylalphitolic acid from Zizyphus jujuba.2012

    • Author(s)
      Ohkura K.
    • Organizer
      International Society for Nutraceuticals & Functional Foods 2012 Annual Conference & Exhibition(ISNFF2012)
    • Place of Presentation
      Kailua-Kona, Hawaii, U.S.A.
    • Related Report
      2012 Annual Research Report
  • [Presentation] キチン分解細菌由来金属プロテアーゼNPR-7のプロ配列に関する構造機能解析2012

    • Author(s)
      三浦優子
    • Organizer
      日本分子生物学会第35回年会
    • Place of Presentation
      福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 木田チリメンシソ単離したガラクトグリセロ脂質は食細胞においてO2-およびNOの産生を阻害する2012

    • Author(s)
      高橋正和、杉山友太、高橋 有、川畑球一、村上 明、入江一浩、久保義人、小林恭一、大東 肇.
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] 食細胞のラジカル産生を抑制する農作物由来化合物の研究2012

    • Author(s)
      高橋正和
    • Organizer
      筑波大学 北アフリカ研究センター(ARENA) 第50回定期セミナー(招待講演)
    • Place of Presentation
      つくば市
    • Related Report
      2011 Research-status Report
  • [Presentation] Monogalactosyldilinolenoylglycerol purified from Perilla frutescens var. crispa inhibits O2- generation in HL-60 cells2011

    • Author(s)
      Takahashi M., Sugiyama Y., Takahashi Y., Kawabata K., Irie K., and Ohigashi H
    • Organizer
      2011 International Conference on Food Factors (ICoFF2011)
    • Place of Presentation
      Taipei, China
    • Year and Date
      2011-11-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Actions of enterobacteria to anti-inflammatory activity of flavanols2011

    • Author(s)
      Kawabata K. and Ohigashi H.
    • Organizer
      2011 International Conference on Food Factors (ICoFF2011)
    • Place of Presentation
      Taipei, China
    • Year and Date
      2011-11-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of nitric oxide generation-inhibitors of Zizyphus jujuba, and analysis of the molecular mechanisms2011

    • Author(s)
      Sugiyama Y., Takahashi M., Kawabata K., Irie K., and Ohigashi H
    • Organizer
      2011 International Conference on Food Factors (ICoFF2011)
    • Place of Presentation
      Taipei, China
    • Year and Date
      2011-11-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 木田チリメンシソに含まれる1,2-di-O-α-linolenoyl-3-O-β- galactosyl-sn-glycerolは食細胞に対してスーパーオキシドおよびNO産生阻害活性を示す2011

    • Author(s)
      高橋正和、杉山友太、高橋 有、川畑球一、小林恭一、大東 肇
    • Organizer
      北陸合同バイオシンポジウム
    • Place of Presentation
      黒部市
    • Year and Date
      2011-11-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 福井県産ホウレンソウのNO産生抑制成分とその活性2011

    • Author(s)
      中村志織、高橋正和、川畑球一、大東 肇
    • Organizer
      北陸合同バイオシンポジウム
    • Place of Presentation
      黒部市
    • Year and Date
      2011-11-11
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] クマリン類の抗炎症作用における分子機序およびその類型化2011

    • Author(s)
      奥村真由、川畑球一、杉山友太、高橋正和, 大東 肇
    • Organizer
      北陸合同バイオシンポジウム
    • Place of Presentation
      黒部市
    • Year and Date
      2011-11-11
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] Monogalactosyldilinolenoylglycerol purified from Perilla frutescens var. crispa inhibits O2- generation in HL-60 cells2011

    • Author(s)
      Takahashi M., Sugiyama Y., Takahashi Y., Kawabata K., Irie K., and Ohigashi H.
    • Organizer
      2011 International Conference on Food Factors (ICoFF2011)
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2011 Research-status Report
  • [Presentation] Actions of enterobacteria to anti-inflammatory activity of flavanols.2011

    • Author(s)
      Kawabata K. and Ohigashi H.
    • Organizer
      2011 International Conference on Food Factors (ICoFF2011)
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2011 Research-status Report
  • [Presentation] Identification of nitric oxide generation-inhibitors of Zizyphus jujuba, and analysis of the molecular mechanisms.2011

    • Author(s)
      Sugiyama Y., Takahashi M., Kawabata K., Irie K., and Ohigashi H.
    • Organizer
      2011 International Conference on Food Factors (ICoFF2011)
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2011 Research-status Report
  • [Presentation] 木田チリメンシソに含まれる1,2-di-O-alpha-linolenoyl-3-O-beta-galactosyl-sn-glycerolは食細胞に対してスーパーオキシドおよびNO産生阻害活性を示す。2011

    • Author(s)
      高橋正和、杉山友太、高橋 有、川畑球一、小林恭一、大東 肇
    • Organizer
      北陸合同バイオシンポジウム
    • Place of Presentation
      黒部市
    • Related Report
      2011 Research-status Report
  • [Book] 食による生活習慣病の予防:学術界のこれからの責務2011

    • Author(s)
      大東 肇
    • Publisher
      日本予防医学会雑誌
    • Related Report
      2012 Final Research Report
  • [Book] がん予防と機能性食品2011

    • Author(s)
      大東 肇
    • Publisher
      Functional Food
    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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