Development of DNA vaccine against intracellular microbial pathogens by using artificially synthesized genes
| Project/Area Number |
23658157
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General fisheries
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| Research Institution | Tokyo University of Marine Science and Technology |
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Principal Investigator |
IKUO Hirono 東京海洋大学, 海洋科学技術研究科, 教授 (00270926)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 人工遺伝子 / DNA ワクチン / 細胞内寄生性細菌 / コドン / 細菌性類結節症 / P. damselae piscicida / DNAワクチン / 魚病細菌 |
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| Research Abstract |
We demonstrated that the DNA vaccine could induce higher expression of antigenic protein by codon optimization and establish high protection against intracellular pathogenic bacteria, Nocardia seriolae and Photobacterium damsela subsp. piscicida .
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Report
(3 results)
Research Products
(12 results)
