| Project/Area Number |
23658173
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fisheries chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
WATABE Shugo 東京大学, 大学院・農学生命科学研究科, 教授 (40111489)
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| Co-Investigator(Renkei-kenkyūsha) |
ASAKAWA Shuichi 東京大学, 大学院・農学生命科学研究科, 教授 (30231872)
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| Research Collaborator |
MATSUMOTO Takuya , 日本学術振興会・特別研究員・PD
KIKUCHI Ryosuke 東京大学, 大学院・農学生命科学研究科, 修士課程
HOLGER Feroudj 東京大学, 大学院・農学生命科学研究科, 修士課程
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| Project Period (FY) |
2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | フグ毒 / テトロドトキシン / フグ毒産生菌 / Vibrio alginolyticus / 生合成経路 / 全ゲノム / 次世代シーケンス |
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| Research Abstract |
The purpose of this study was to elucidate the biosynthesis pathway of pufferfish toxin, tetrodotoxin(TTX), in TTX-producing marine bacterium Vibrio alginolyticus by the whole genome analysis. We identified 6 strains of V. alginolyticus from intestinal flora of pufferfish and TTX was detected from 2 strains by MALDI-TOF-MS analysis. Genomic DNA samples extracted from the TTX-producing V. alginolyticus strains were subjected to whole genome analysis by the next-generation sequencing technology.
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