Clarification of metabolic mechanism of non-enzymatic glycation compounds in chickens
| Project/Area Number |
23658215
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Iwate University |
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Principal Investigator |
KITA Kazumi 岩手大学, 農学部, 教授 (20221913)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ニワトリ / 筋芽細胞 / タンパク質合成 / グルコース / トリプトファン / アマドリ化合物 / β-カルボリン / PHP-THβC / グリケーション / 蛋白質合成 / 筋肉 / 腎臓 / 脾臓 |
|---|
| Research Abstract |
Firstly, the interactive effect of PHP-THβC on protein synthesis of chicken embryo myoblasts was examined. When fetal calf serum in the medium was 10%, protein synthesis was significantly increased by elevating PHP-THβC concentration more than 4 μM.
Secondly, the investigation to study the nutritional value for PHP-THβC revealed that PHP-THβC could not be a precursor for protein synthesis instead of tryptophan.
Thirdly, under normal condition, the concentrations of PHP-THβC and glucose-tryptophan Amadori product were approximately 1.5μM and 3.0 μM, respectively.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Detection of two types of glycated tryptophan compounds in the plasma of chickens fed tryptophan excess diets2013
Author(s)
Kita, K., Kawashima, Y., Makino, R., Namauo, T., Ogawa, S., Muraoka, H. and Fujimura, S.
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Journal Title
Journal of Poultry Science
Volume: 50
Pages: 138-142
NAID
Related Report
Peer Reviewed
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