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Advanced utilization of fermented food by-products: Development of Eco-immuno feeds"supporting health and environment

Research Project

Project/Area Number 23658216
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Zootechnical science/Grassland science
Research InstitutionTohoku University

Principal Investigator

KITAZAWA Haruki  東北大学, 大学院・農学研究科, 准教授 (10204885)

Co-Investigator(Kenkyū-buntansha) ASO Hisashi  東北大学, 大学院・農学研究科, 教授 (50241625)
Co-Investigator(Renkei-kenkyūsha) SUDA Yoshihito  宮城大学, 食産業学部, 准教授 (90404847)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords畜産物利用 / 発酵食品 / 未活用資源 / ブタ / イムノバイオティクス / イムノジェ ニクス / エコフィード / イムノジェニクス / 家畜 / 腸管上皮 / ウシ / 腸管パイエル板 / 飼料 / 免疫
Research Abstract

In this study, for beneficial use of lactic acid bacterial fermentation liquid as underutilized resources, we focused on immunobiotics and immunogenics in the liquid and relating products, and examined fundamental analysis to develop as a novel “Immuno-Eco Feeds" contributing to the reduction of health hazards risk as livestock antimicrobial alternatives. Specifically, a safety of the liquid and immuneregulatory effects in porcine intestinal cells were evaluated, and in vivo confirmation study and in vitro detailed study of its mechanisms were also conducted.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (7 results) (of which Invited: 1 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Advanced application of bovine intestinal epithelial cell line for evaluating regulatory effect of lactobacilli against heat-killed enterotoxigenic Escherichia coli-mediated inflammation.2013

    • Author(s)
      Takanashi, N. et al.
    • Journal Title

      BMC Microbiol.

      Volume: 13(54) Issue: 1 Pages: 1-16

    • DOI

      10.1186/1471-2180-13-54

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunobiotic Lactobacillus jensenii Modulates the Toll-Like Receptor 4-Induced Inflammatory Response via Negative Regulation in Porcine Antigen-Presenting Cells2012

    • Author(s)
      Villena, J., H.Kitazawa, et al
    • Journal Title

      Clin.Vac.Immunol.

      Volume: (未定)(印刷中) Issue: 7 Pages: 1038-1053

    • DOI

      10.1128/cvi.00199-12

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lactobacillus plantarumNo.14株が生産する菌体外多糖の化学的性状と免疫活性2011

    • Author(s)
      橋口健司、長田裕子、吉田睦子、室伏陽、北澤春樹
    • Journal Title

      日本乳酸菌学会誌

      Volume: 22(2) Pages: 100-105

    • NAID

      10029752915

    • URL

      https://www.jstage.jst.go.jp/browse/jslab/

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lactobacillus plantarum No.14 株が生産する 菌体外多糖の化学的性状と免疫活性.2011

    • Author(s)
      橋口、吉田、北澤ら
    • Journal Title

      日本乳酸菌学会誌

      Volume: 22 Pages: 100-105

    • NAID

      10029752915

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ブタの生産性を高めるイムノバイオティック乳酸菌の抗病性効果2013

    • Author(s)
      須田義人、下斗米陽子、細矢翔一、石田光晴、麻生久、牧野聖也、池上秀二、伊藤裕之、北澤春樹
    • Organizer
      日本畜産学会第116回大会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 乳酸菌菌体外多糖のパターン認識受容体を介する免疫調節機能特性2012

    • Author(s)
      室伏陽、和知俊、細矢翔一、遠野雅徳、島津朋之、下里剛士、川井泰、齋藤忠夫、橋口健司、吉田睦子、北澤春樹
    • Organizer
      平成24年度酪農科学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-08-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of pattern recognition receptors in the therapeutic effect of immunobiotics and immunogenics2012

    • Author(s)
      Kitazawa, H. , J. Villena
    • Organizer
      LVII Reunion Cientifica Anual de la Sociedad Argentina de Investigacion Clinica, LX Reunion Cientifica Anual de la Sociedad Argentina de Inmunologia
    • Place of Presentation
      Mar del Plata、Argentina(招待講演)
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳酸菌菌体外多糖の異なるパターン認識受容体を介する免疫調節機能特性2012

    • Author(s)
      室伏陽、和知俊、細矢翔一、遠野雅徳、島津朋之、下里剛士、川井泰、齋藤忠夫、橋口健司、吉田睦子、北澤春樹
    • Organizer
      日本畜産学会第115回大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳酸菌菌体外多糖のパターン認識受容体を介する免疫調節機能特性2012

    • Author(s)
      室伏 陽、北澤春樹ら
    • Organizer
      平成24年度 酪農科学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of pattern recognition receptors in the therapeutic effect of immunobiotics and immunogenics.2012

    • Author(s)
      Kitazawa, H.
    • Organizer
      LVII Reunion Cientiica Anual de la Sociedad Argentina de Investigacion Clinica, LX Reunion Cientifica Anual de la Sociedad Argentina de Inmunologia.
    • Place of Presentation
      Mar del Plata, Argentina
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 乳酸菌菌体外多糖の異なるパターン認識受容体を介する免疫調節機能特性.2012

    • Author(s)
      室伏、和知、北澤ら
    • Organizer
      日本畜産学会第115回大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Book] Nova Science Publishers, Inc.2012

    • Author(s)
      Villena, J., H. Aso, S. Alvarez, H. Kitazawa
    • Publisher
      Probiotics: Sources, Types and Health Benefits
    • Related Report
      2012 Final Research Report
  • [Book] Probiotics: Sources, Types and Health Benefits.2012

    • Author(s)
      Villena, J., H. Kitazawa et al.
    • Publisher
      Nova Science Publishers, Inc.
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.rpip.tohoku.ac.jp/seeds/profile/216

    • Related Report
      2012 Final Research Report
  • [Remarks] 家畜対応型の腸管免疫調節機能性の評価系構築

    • URL

      http://www.rpip.tohoku.ac.jp/seeds/profile/216/no_count:1/lang:jp/request:fccdd3ffea22278a6d398931fd96cf86/

    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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