Generation of rat iPS cells
| Project/Area Number |
23658227
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied animal science
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 発生工学 / iPS / モデル動物 / 再生医療 / iPS細胞 / ラット / 遺伝子導入ラット / 発現誘導 |
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| Research Abstract |
We tried to generate iPS cells from our transgenic rat having drug-inducible reprogramming factors. However, there were some difficulties in mating. Then, as a first step to generate iPS cells and to analyze the reprogramming mechanisms, I focused on Oct4-binding sites in the nanog gene which is a marker gene of ES cells. I identified novel 9 novel Oct4-binding sequences in the rat nanog gene.
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Report
(3 results)
Research Products
(7 results)
