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Generation of rat iPS cells

Research Project

Project/Area Number 23658227
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied animal science
Research InstitutionToho University

Principal Investigator

YANAI Kazuyuki  東邦大学, 理学部, 准教授 (30360704)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords発生工学 / iPS / モデル動物 / 再生医療 / iPS細胞 / ラット / 遺伝子導入ラット / 発現誘導
Research Abstract

We tried to generate iPS cells from our transgenic rat having drug-inducible reprogramming factors. However, there were some difficulties in mating. Then, as a first step to generate iPS cells and to analyze the reprogramming mechanisms, I focused on Oct4-binding sites in the nanog gene which is a marker gene of ES cells. I identified novel 9 novel Oct4-binding sequences in the rat nanog gene.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2012 Other

All Presentation (7 results)

  • [Presentation] ヒトゲノムにおけるアンドロゲンレセプターの結合配列の系統的な同定とその解析2012

    • Author(s)
      村崎亜起子
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Genome-wide identification and characterization of Retinoid X Receptor homodimer binding sites by a genetic selection in yeast2012

    • Author(s)
      Hiroki Saito
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Genome-wide identification and characterization of Retinoic Acid Receptor/Retinoid X Receptor heterodimer binding sites by a genetic selection in yeast2012

    • Author(s)
      Takatsugu Kosugi
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Identification and Characterization of Human Genomic Binding Sites for Retinoic Acid Receptor/Retinoid X Receptor heterodimers2012

    • Author(s)
      Takatsugu Kosugi
    • Organizer
      生命医薬情報学連合大会
    • Place of Presentation
      タワーホテル船堀(東京都)
    • Year and Date
      2012-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification and characterization of retinoic acid receptor/retinoid X receptor heterodimers binding sites in human genome2012

    • Author(s)
      Takatsugu Kosugi
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2012-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification and characterization of retinoic acid receptor/retinoid X receptor heterodimers binding sites in human genome.

    • Author(s)
      Takatsugu Kosugi
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification and Characterization of Human Genomic Binding Sites for Retinoic Acid Receptor/Retinoid X Receptor heterodimers

    • Author(s)
      Takatsugu Kosugi
    • Organizer
      生命医薬情報学連合大会
    • Place of Presentation
      タワーホテル船堀(東京都)
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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