| Project/Area Number |
23658230
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Basic veterinary science/Basic zootechnical science
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
OTSUGURO Kenichi 北海道大学, 大学院・獣医学研究科, 准教授 (40344494)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ITO Shigeo 北海道大学, 大学院・獣医学研究科, 教授 (40109509)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 硫化水素 / TRPA1 / 細胞内カルシウム / RIN14B / 知覚神経 / 5-HT |
|---|
| Research Abstract |
The effects of an hydrogen sulfide (H2S) donor, NaHS, on the sensory neurons and model cells (RIN14B) for enterochromaffin cells were examined. H2S increased intracellular Ca2+ levels via the activation of TRPA1, resulting in neuronal excitation and secretory responses. The neuronal model PC12 cells expressed AST (aspartate aminotransferase)/MPST (mercaptopyruvate sulfurtransferase) and generated H2S. In the intestine, it is suggested that neuronal cells not only respond to intraluminal H2S but also synthetizes H2S to regulate gastrointestinal functions.
|
