| Project/Area Number |
23658231
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
ITO Shigeo 北海道大学, 大学院・獣医学研究科, 教授 (40109509)
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| Co-Investigator(Renkei-kenkyūsha) |
OTSUGURO Kenichi 北海道大学, 大学院・獣医学研究科, 准教授 (40344494)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 神経科学 / 脊髄 / 侵害受容経路 / 反射電位 / 知覚神経 / 内因性アミン / ドパミン / 5-HT / 獣医学 / 薬理学 |
|---|
| Research Abstract |
The effects of algesic and analgesic agents on the sensory neurons and spinal nociceptive pathways were examined to reveal the species differences in pain transmission. In the rat sensory neurons, the algesic agents, capsaicin and mustard oil, activated TRP channels. The electrophysiological features of spinal nociceptive reflex potentials and the effects of morphine in mice were similar to those in rats. Some differences in the effects of biogenic amines between rats and mice were observed, suggesting that there are species differences in pain control mechanisms by descending inhibitory neuronal pathways in the spinal cord.
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