Host cell factors to induce Toxoplasma gondii stage-conversion

Research Project

Project/Area Number	23658239
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	Gifu University
Principal Investigator	TAKASHIMA YASUHIRO 岐阜大学, 応用生物科学部, 准教授 (20333552)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	潜伏 / トキソプラズマ / 筋肉
Research Abstract	Statistical difference of frequency of Toxoplasma gondii stage-conversion in normal fibroblast and a fibroblast cell line which had been transformed with MyoD. MyoD is key molecule to induce differentiation of myoblast, in which T. gondii preferencially converts its stage. Howevere, the result of this study indicates that MyoD expression is not enough to induce the stage-conversion. In contrast, it was strongly suggested that p38 MAPK related with progression of stage-conversion from tachyzoite to bradyzoite.