Molecular communication between myogenic stem cells and activatedmacrophages during muscle growth and regeneration
| Project/Area Number |
23658242
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Kyushu University |
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Principal Investigator |
TATSUMI Ryuichi 九州大学, 大学院・農学研究院, 准教授 (40250493)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUNOYA Wataru 九州大学, 大学院・農学研究院, 助教 (20404056)
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| Research Collaborator |
ANDERSON Judy E 加国マニトバ大学, 理学部, 教授
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 骨格筋 / 筋幹細胞 / マクロファージ / 筋芽細胞 / 筋肥大・再生 / 細胞間コミュニケーション / 肝細胞増殖因子HGF / 神経軸索成長ガイダンス因子semaphorin 3A / semaphorin 3A / 食肉 / 衛星細胞 / 筋肥大 / 筋再生 |
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| Research Abstract |
A variety of experimental approaches have revealed that acute muscle damage induces massive macrophage infiltration of the injury site, in which two polarized phenotypes, classically activated macrophages (also called proinflammatory phagocytotic macrophages, currently classified as M1) and alternatively activated macrophages (antiinflammatory macrophages or M2), have been well documented as distinct functional populations. The present study provided additional evidence that M2 macrophages may contribute to regenerative myogenesis by promoting myoblast migration (chemoattraction in a bell-shaped HGF-dose dependent manner) and differentiation (characterized by up-regulation of myogenin and myosin heavy chain expression), predominantly at 5-7 days after cardiotoxin/crush injury of mouse muscle. By understanding this spatiotemporal communication between M2s and myoblasts, we will be able to design new procedures that specifically target the regenerative strategy to ensure muscle growth and repair, contributing to the meat-animal production and human sports and health sciences aimed to enhance physical performance and medical therapies for age-related muscle atrophy.
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Report
(3 results)
Research Products
(10 results)
