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Molecular communication between myogenic stem cells and activatedmacrophages during muscle growth and regeneration

Research Project

Project/Area Number 23658242
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionKyushu University

Principal Investigator

TATSUMI Ryuichi  九州大学, 大学院・農学研究院, 准教授 (40250493)

Co-Investigator(Kenkyū-buntansha) MIZUNOYA Wataru  九州大学, 大学院・農学研究院, 助教 (20404056)
Research Collaborator ANDERSON Judy E  加国マニトバ大学, 理学部, 教授
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords骨格筋 / 筋幹細胞 / マクロファージ / 筋芽細胞 / 筋肥大・再生 / 細胞間コミュニケーション / 肝細胞増殖因子HGF / 神経軸索成長ガイダンス因子semaphorin 3A / semaphorin 3A / 食肉 / 衛星細胞 / 筋肥大 / 筋再生
Research Abstract

A variety of experimental approaches have revealed that acute muscle damage induces massive macrophage infiltration of the injury site, in which two polarized phenotypes, classically activated macrophages (also called proinflammatory phagocytotic macrophages, currently classified as M1) and alternatively activated macrophages (antiinflammatory macrophages or M2), have been well documented as distinct functional populations. The present study provided additional evidence that M2 macrophages may contribute to regenerative myogenesis by promoting myoblast migration (chemoattraction in a bell-shaped HGF-dose dependent manner) and differentiation (characterized by up-regulation of myogenin and myosin heavy chain expression), predominantly at 5-7 days after cardiotoxin/crush injury of mouse muscle. By understanding this spatiotemporal communication between M2s and myoblasts, we will be able to design new procedures that specifically target the regenerative strategy to ensure muscle growth and repair, contributing to the meat-animal production and human sports and health sciences aimed to enhance physical performance and medical therapies for age-related muscle atrophy.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2013 2012 2011 Other

All Presentation (7 results) Remarks (3 results)

  • [Presentation] 筋肥大・再生における筋幹細胞・運動神経末端・マクロファージのクロストークダイナミクス(仮題)2013

    • Author(s)
      辰巳隆一
    • Organizer
      平成25年度日本栄養・食糧学会北海道支部会シンポジウム「組織の機能を支える細胞間クロストーク」
    • Place of Presentation
      北海道大学大学院農学研究院, 北海道札幌市
    • Year and Date
      2013-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 活性化マクロファージは筋芽細胞の遊走性の調節に関与する2013

    • Author(s)
      坂口昇平・生野淳一・水野谷航・中村真子・辰巳隆一・池内義秀
    • Organizer
      第116回日本畜産学会大会
    • Place of Presentation
      安田女子大学, 広島市
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 筋幹細胞による筋再生制御ダイナミクス2012

    • Author(s)
      辰巳隆一
    • Organizer
      第245回川崎医学会講演会
    • Place of Presentation
      川崎医科大学図書館小講堂, 倉敷市
    • Year and Date
      2012-12-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 筋幹細胞・運動神経軸索・活性化マクロファージのクロストーク2012

    • Author(s)
      辰巳隆一
    • Organizer
      北大食肉科学セミナー「骨格筋における異種細胞間コミュニケーションに関する研究展開」
    • Place of Presentation
      北海道大学大学院農学研究院, 北海道札幌市
    • Year and Date
      2012-05-11
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 筋肥大・再生における筋幹細胞・運動神経末端・マクロファージのコミュニケーションに関する研究展開2012

    • Author(s)
      辰巳隆一
    • Organizer
      農業・食品産業技術総合研究機構 畜産草地研究所セミナー
    • Place of Presentation
      畜産草地研究所, 茨城県つくば市
    • Year and Date
      2012-03-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 筋肥大・再生における筋幹細胞・運動神経末端・マクロファージのコミュニケーションに関する研究展開2012

    • Author(s)
      辰巳隆一
    • Organizer
      農業・食品産業技術総合研究機構 畜産草地研究所セミナー(招待講演)
    • Place of Presentation
      畜産草地研究所, 茨城県つくば市池ノ台2
    • Related Report
      2011 Research-status Report
  • [Presentation] 活性化マクロファージは骨格筋再生に関与する2011

    • Author(s)
      生野淳一・坂口昇平・佐藤祐介・水野谷航・中村真子・辰巳隆一・池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学獣医学部十和田キャンパス
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Remarks]

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/details/K000315/research.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.agr.kyushu-u.ac.jp/lab/muscle_and_meat/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://bbs1.agr.kyushu-u.ac.jp/biosci-biotech/chikusan/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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