in vivo imaging of flavivirus encephalitis
| Project/Area Number |
23658243
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ウイルス / 脳神経疾患 / 獣医学 / 感染症 / 分子イメージング / 日本脳炎ウイルス / ダニ媒介性脳炎ウイルス / PET / SPECT / マウスモデル / 病態 / ウイルス性脳炎 |
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| Research Abstract |
In this study, we developed an in vivo imaging of flavivirusencephalitis using a mouse model. We inoculated Japanese encephalitis or Tick-borne encephalitis virus in mice, and compared accumulations of 18F-FDG between dying and surviving mice using positron emission tomography. Dying mice showed reduced levels of 18F-FDG uptakes in a part of brains compared with surviving mice. These results will provide useful information for clinical diagnosis of flavivirus encephalitis.
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Report
(3 results)
Research Products
(36 results)
