| Project/Area Number |
23658247
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAWA HIROFUMI 北海道大学, 人獣共通感染症リサーチセンター, 教授 (30292006)
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| Co-Investigator(Kenkyū-buntansha) |
HASEBE Rie 北海道大学, (連合)獣医学研究科, 講師 (70431335)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 人獣共通感染症 / ウイルス / 脳炎 / タンパク質 |
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| Research Abstract |
West Nile virus (WNV) is widely distributed in United States and African countries and so on. The mortality rate of WNV encephalitis is still high. This research project attempts to analyze the intracellular trafficking mechanisms of WNV and find basic findings which are related to therapeutic strategy against WNV encephalitis.
We found that following cellular entry, WNV subviral particle (SVP) movements could be divided into two phases: early (slow movement) and late (fast movement) phase. Moreover, fast viral particle movement at the late phase correlated with SVP-microtubule association. In addition, we found that the release of WNV from cells is regulated by cellular protein, Rab. According to these results, there are some possibilities to establish the therapeutic strategies against WNV encephalitis in which we can target cellular proteins, such as tubulin and Rab.
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