Pathogenesis of influenza virus-associated encephalopathy of childhood induced in animal model

• Project/Area Number: 23658250
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied veterinary science
• Research Institution: Hokkaido University
• Principal Investigator: UMEMURA Takashi 北海道大学, 大学院・獣医学研究科, 特任教授 (00151936)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: インフルエンザ性脳症 / リポ多糖体 / 小児 / 血液脳関門 / 高サイトカイン血症 / インフルエンザ脳症 / 感染症 / ウイルス / 脳神経疾患 / 獣医学 / 病理学 / 動物

Research Abstract

In the present study, I demonstrated that influenza virus (IFV) infection to the lungs of suckling mice enhanced encephalopathy and hypercytokinemia due to lipopolysaccharide (LPS) inoculation, and brain pathology, hypercytokinemia and absence of IFV in the brain of the animal model treated with IFV and LPS were similar to IFV-associated encephalopathy of childhood. Furthermore, it was suggested from the present study that the apoptosis of vascular endothelial cell and astrocytes causing increased permeability of blood brain barrier might be the major contributing factor forIFV-associated encephalopathy of childhood.

Research Products

• [Journal Article] CXCL12 improves immune responses to neurotropic virus propagation in the CNS by attracting antigody secreting cells (2012)
  • Author(s): Lee HK, Lee HK, Sunden Y, Sakai Y, Ochiai K, Umemura T
  • Journal Title: Vet Immunol Microbiol Volume: 150 Pages: 19-26
  • Peer Reviewed
• [Journal Article] Reintroduction of H5N1 highly pathogenic avian influenza virus by migratory water birds, causing poultry outbreaks in the 2010-2011 winter season in Japan (2012)
  • Author(s): Sakoda Y, Ito H, Uchida Y, Okamatsu M, Yamamot N, Soda K, Nomura N, Kuribayashi S, Shichnohe S, Sunden Y, Umemura T, Usui T, Ozaki H, Yamaguchi T, Murase T, Ito T, Saito T, Takada A, Kida H
  • Journal Title: J Gen Virol Volume: 93 Pages: 541-550
  • NAID: 120005228206
  • Peer Reviewed
• [Journal Article] Experimental intracerebral vaccination protects mouse from a neurotropic virus by attracting antibody secreting cells to the CNS (2011)
  • Author(s): Lee HK, Sunden Y, Ochiai K, Umemura T
  • Journal Title: Immunol Lett Volume: 139 Pages: 102-109
  • Peer Reviewed
• [Remarks]
  • URL: http://www.researcherid.com