A concept on innovative treatments to epitheliotropiclymphoma targeting to molecules associated with segregation of lymphocytes from lesional skin

Research Project

Project/Area Number	23658261
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Clinical veterinary science
Research Institution	Gifu University
Principal Investigator	MAEDA Sadatoshi 岐阜大学, 応用生物科学部, 教授 (50377694)
Co-Investigator(Kenkyū-buntansha)	SHIBATA Sanae 岐阜大学, 応用生物科学部, 助教 (20588917)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	内科 / 癌 / トランスレーショナルリサーチ / 獣医学 / 遺伝子
Research Abstract	The present results indicated that the skin-homing property of CCR4, CCR7, CCR10 and CXCR3 may contribute to the development of specific accumulation of neoplastic lymphocytes in the skin, which is the new concept of involvement of active skin migration of cytotoxic T-cells from blood circulation of cECL. These chemokine receptors could be therapeutic targets by regulating the migration of neoplastic lymphocytes in cECL.