| Project/Area Number |
23658283
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 線虫 / アルギニンメチル化反応 / 細胞機能 / アルギニンメチル化酵素 / 寿命 / prmt-1 / daf-16 / daf-12 / メチルアルギニン / モノメチルアルギニン / ジメチルアルギニン |
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| Research Abstract |
Caenorhabditis elegans, about 1 mm-long round worms, is a model organism with genetic advantages and used for the studies on cell death and longevity. On the other hand, as the technologies such as in vitro protein synthesis and Mass spectrometry are innovatively advanced, it becomes important to understand the biochemical functions of proteins. In the present study, combined with genetics and biochemistry, we tried toexamine the reactions of protein arginine methylation related to longevity.
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