Biochemical studies on longevity using multicellular microorganism
Project/Area Number |
23658283
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Applied molecular and cellular biology
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 線虫 / アルギニンメチル化反応 / 細胞機能 / アルギニンメチル化酵素 / 寿命 / prmt-1 / daf-16 / daf-12 / メチルアルギニン / モノメチルアルギニン / ジメチルアルギニン |
Research Abstract |
Caenorhabditis elegans, about 1 mm-long round worms, is a model organism with genetic advantages and used for the studies on cell death and longevity. On the other hand, as the technologies such as in vitro protein synthesis and Mass spectrometry are innovatively advanced, it becomes important to understand the biochemical functions of proteins. In the present study, combined with genetics and biochemistry, we tried toexamine the reactions of protein arginine methylation related to longevity.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Production of free methylarginines via the proteasome and autophagy pathways in cultured cells.2011
Author(s)
Shirakawa, T., Kako,K., Shimada, T., Nagashima, Y., Nakamura, A., Ishida, J.,Fukamizu, A.
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Journal Title
Mol. Med. Rep.
Volume: 4
Pages: 615-620
DOI
Related Report
Peer Reviewed
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[Journal Article] Asymmetric arginine dimethylation determines life span in C.elegans by regulating forkhead transcription factor DAF-162011
Author(s)
Takahashi Y., Daitoku H., Hirota K., Tamiya H., Yokoyama A., Kako K., Nagashima Y., Nakamura A., Shimada T., Watanabe S., Yamagata K., Yasuda K., Ishii N., Fukamizu A.
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Journal Title
Cell Metabolism
Volume: 13
Issue: 5
Pages: 505-516
DOI
Related Report
Peer Reviewed
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[Presentation] The promoter region of sams-1 gene plays an important role in determining brood size regulation.2012
Author(s)
Sakuta, G., Tamiya, H., Hirota, K., Takahashi, Y., Daitoku, H., Kaneko, Y., Iizuka,K., and Fukamizu, A
Organizer
5thEast Asia C. elegans Meeting
Place of Presentation
Chientan Youth Activity Center、台湾
Year and Date
2012-06-28
Related Report
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[Presentation] S-adenosylmethionine synthetase SAMS-1 regurates brood size in C. elegans.2011
Author(s)
Tamiya, H., Hirota, K., Takahashi, Y., Daitoku, H., Ishii, N., and Fukamizu, A
Organizer
18thInternational C.elegans Meeting、University of California
Place of Presentation
アメリカ
Year and Date
2011-06-22
Related Report
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