Production of edible vaccine made from Virus-like particle in tomato
| Project/Area Number |
23658284
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ONO Michiyuki 筑波大学, 生命環境系, 准教授 (50201405)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEUCHI Kaoru 筑波大学, 医学医療系, 准教授 (00192162)
MORIKAWA Kazuya 筑波大学, 医学医療系, 准教授 (90361328)
YASUTOMI Ysauhiro 独立行政法人医薬基盤研究所, センター長 (90281724)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | タンパク質 / 食べるワクチン / ウイルス様粒子 / キメラVLP / トマト / 遺伝子組換え作物 / 果実特異的発現 / 形質転換植物 |
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| Research Abstract |
Virus-like particle (VLP) is self-assembled capsid protein ofvirus and the best candidate of edible vaccine, because VLP is resistant to digestionand can be targeted to the immune system of intestine. We made transgenic tomato plants(Solanum lycopersicum cv. Micro-Tom) expressing capsid protein of Human Hepatitis EVirus (HEV) fused with the M2 universal epitope of Influenza.
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Report
(3 results)
Research Products
(9 results)
