| Project/Area Number |
23659001
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
KONDO Yoshinori 東北大学, 大学院・薬学研究科, 教授 (90162122)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 有機反応学 / 分子活性化 / 分子変換 / 有機触媒 / オニウムアミド / 脱プロトン化 / 芳香族複素環 / 不斉変換 / 芳香複素環 / 脱プロトン / ホスファゼニウム / 官能基選択性 / 部位選択性 |
|---|
| Research Abstract |
Organocatalytic process has been regarded to be attractive from viewpoints of selectivity, safety, and sustainability, and the development of organocatalytic processes for deprotonative functionalization of aromatics and heteroaromatics is considered to be one of highly challenging subjects in organic synthesis. We have been working on organocatalytic transformation of aromatic and heteroaromatic compounds, and we developed a simple catalytic deprotonative functionalization of heteroaromatic ring under metal-free mild conditions using onium amides, generated in situ from the combination of aminosilanes and onium fluorides, as bases.
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