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Development of the strategy for inducing the selective point mutation by regulation of the electron transfer in the duplex DNA

Research Project

Project/Area Number 23659002
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Chemical pharmacy
Research InstitutionTohoku University

Principal Investigator

NAGATSUGI Fumi  東北大学, 多元物質科学研究所, 教授 (90208025)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords生体関連物質 / 核酸化学 / 電子移動 / 変異誘導 / 光電子移動 / アントラキノン / オリゴヌクレオチド / 光増感剤 / アルキル化
Research Abstract

The chemical reactions to DNA are known to induce the mutation in the genetic information and leads to the various diseases, such as cancer. Especially, the electron transfer through duplex DNA can occur under the conditions of oxidative stress, and induce the DNA damage, for example oxidative damage. But it is very difficult to regulate the selectivity of these reactions. In this study, we have developed the new strategy to induce the selective point mutation by regulation of the electron transfer through the DNA. For achievement of our study, there are two key points; one is the producing the effective radical cation by photo-reaction, and second is the reaction to induce the nucleophilic reaction or the oxidative reaction. In this study, we synthesized the oligonucleotides containing anthraquinone as a photosensitizer and 2-amino-6-vinyl derivatives as a reactive moiety. These oligonucleotide provides the possibility to induce the selective reactions to target bases.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (80 results)

All 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (71 results) (of which Invited: 2 results)

  • [Journal Article] Synthesis of peptide-conjugated light-driven molecular motors and evaluation of their DNA-binding properties2013

    • Author(s)
      Fumi Nagatsugi, Yusuke Takahashi, Maiko Kobayashi, Shunsuke Kuwahara, Shuhei Kusano, Tomoko Chikuni, Shinya Hagihara and Nobuyuki Harada
    • Journal Title

      Mol. Bio Syst.

      Volume: 9 Issue: 5 Pages: 969-973

    • DOI

      10.1039/c2mb25520k

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fast DNA Interstrand Cross-linking Reaction by 6-Vinylpurine2012

    • Author(s)
      Imoto, S., Chikuni, T., Kansui, H, Kunieda, T. , Nagatsugi, F.
    • Journal Title

      Nucleosides Nucleotides Nucleic Acids.

      Volume: 31 Issue: 10 Pages: 752-762

    • DOI

      10.1080/15257770.2012.726756

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ynthesis of 6-amino-2-vinyl purine derivatives for cross-linking and evaluation of the reactivity2012

    • Author(s)
      Kusano,S., Sakuraba, T., Hagihara, S., Nagatsugi, F.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 22 Issue: 22 Pages: 6957-6951

    • DOI

      10.1016/j.bmcl.2012.08.122

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Production of truncated protein by the crosslink formation of mRNA with 2’-OMe oligoribonucleotide containing 2-amino-6-vinylpurine2012

    • Author(s)
      Hagihara, S., Kusano, S., Lin, W.C., Chao, X.G., Hori, T., Imoto, S., Nagatsugi, F.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 22 Issue: 12 Pages: 3870-3872

    • DOI

      10.1016/j.bmcl.2012.04.123

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imoto Induced cross-linking reactions to target genes using modified oligonucleotides2011

    • Author(s)
      F.Nagatsugi,and S.
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 9 Issue: 8 Pages: 2579-2585

    • DOI

      10.1039/c0ob00819b

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of the Highly Selective Reactions to Target Gene for the Control of the Gene Expression in Cells2011

    • Author(s)
      F.Nagatsugi
    • Journal Title

      Journal of Synthetic Organic Chemistry Japan

      Volume: 69 Pages: 108-117

    • NAID

      10027916316

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] チミンとの架橋反応性を有する新規人工核酸の開発2011

    • Author(s)
      永次史
    • Journal Title

      化学工業

      Volume: 62 Pages: 137-142

    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Journal Article] 自己活性化インテリジェント人工核酸の創製2011

    • Author(s)
      永次史
    • Journal Title

      核酸化学のニュートレンド,DNA・RNAの新たな可能性を拓く,CSJカレントレビュー

      Pages: 48-55

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 自己活性化インテリジェント人工核酸の創製2011

    • Author(s)
      永次 史
    • Journal Title

      核酸化学のニュートレンド, DNA・RNAの新たな可能性を拓く, CSJ カレントレビュー(化学同人)

      Volume: 06 Pages: 48-55

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 塩基欠損部位を持つ2本鎖DNAにおける部位特異的修飾方法の開発2013

    • Author(s)
      佐藤憲大、茂木琢真、萩原伸也、永次史
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学、滋賀県
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 架橋性オリゴ核酸を用いた細胞内遺伝子発現制御機能性オリゴ核酸のRNAへの架橋形成による遺伝子発現制御2013

    • Author(s)
      萩原伸也、草野修平、井田裕太、岩本直生、永次史
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学、滋賀県
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] グアニン類縁体に対する架橋形成ピリミジン誘導体の反応性2013

    • Author(s)
      草野修平、萩原伸也、永次史
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学、滋賀県
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 立体配座を固定化した新規架橋性分子の開発2013

    • Author(s)
      井田裕太、草野修平、岩本直生、萩原伸也、永次史
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学、滋賀県
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Development of the Chemical Strategy for Regulation of Gene Expression2013

    • Author(s)
      Fumi Nagatsugi
    • Organizer
      Asian Chemical Biology Initiative
    • Place of Presentation
      Bangkok, Thai(招待講演)
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of the Chemical Strategy for Regulation of Gene Expression2013

    • Author(s)
      Fumi Nagatsugi
    • Organizer
      2st Asian Chemical Biology Initiative
    • Place of Presentation
      Bangkok, Thai
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] グアニンに対して選択的に反応する架橋反応剤の開発2013

    • Author(s)
      永次 史、草野修平、萩原 伸也
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 極めて高い反応性を持つ架橋反応性オリゴヌクレオチドによるテロメラーゼ阻害の検討2013

    • Author(s)
      岩本 直生、草野 修平、萩原 伸也、永次 史、
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 架橋反応性ピリミジン誘導体の合成および評価2012

    • Author(s)
      草野修平、萩原伸也、永次史
    • Organizer
      有機合成化学若手研究者の仙台セミナー
    • Place of Presentation
      東北大学、仙台
    • Year and Date
      2012-12-01
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 有機合成化学を基盤とした化学的遺伝子発現制御分子ツールの開発2012

    • Author(s)
      永次史
    • Organizer
      有機合成化学協会夏季セミナー明日の有機合成化学
    • Place of Presentation
      大阪
    • Year and Date
      2012-08-31
    • Related Report
      2012 Final Research Report
  • [Presentation] 糖部修飾型架橋反応性ピリミジン誘導体の開発2012

    • Author(s)
      草野修平、萩原伸也、茂木琢真、永次史
    • Organizer
      天然物ケミカルバイオロジー:分子標的と活性制御第一回若手研究者ワークショップ
    • Place of Presentation
      東京医科歯科大学、東京
    • Year and Date
      2012-06-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of the Acyclic Pyrimidine Derivative for Selective Cross-linking Reaction to 8-Oxoguanine2012

    • Author(s)
      Shuhei Kusano, Shinya Hagihara and Fumi Nagatsugi
    • Organizer
      The 39th International Symposium on Nucleic Acid Chemistry
    • Place of Presentation
      Nagoya University, Nagoya
    • Related Report
      2012 Final Research Report
  • [Presentation] Crosslinking of oligonucleotide to the target mRNA pauses in vitoro translation2012

    • Author(s)
      Atsushi Shibata, Atsushi Nishimoto, Kazumitsu Onizuka, Daichi Jitsuzaki, Kosuke Akishima, Yosuke Taniguchi, Fumi Nagatsugi,, Shigeki Sasaki
    • Organizer
      The 39th International Symposium onNucleic Acid Chemistry
    • Place of Presentation
      Nagoya University, Nagoya
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of Crosslink Forming Oligonuleotides for Intracellular Gene Regulation2012

    • Author(s)
      Shinya Hagihara, Yuta Ida, Nao Iwamoto, Shuhei Kusano, Fumi Nagatsugi
    • Organizer
      The 39th International Symposium on Nucleic Acid Chemistry
    • Place of Presentation
      Nagoya University, Nagoya
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Synthesis of Peptide Nucleic Acid (PNA) Incorporating4-Amino-6-Oxo-2-Vinylpyrimidine (AOVP)2012

    • Author(s)
      Yuki Ishizawa, Kaname Sasaki, Nao Iwamoto, Shinya Hagihara, Fumi Nagatsugi
    • Organizer
      The 39th International Symposium on Nucleic Acid Chemistry
    • Place of Presentation
      Nagoya University, Nagoya
    • Related Report
      2012 Final Research Report
  • [Presentation] 遺伝子発現の化学的制御を目指した方法論の開発2012

    • Author(s)
      永次史、草野修平、岩本直生、佐藤憲大、佐々木要、萩原伸也
    • Organizer
      第61回高分子討論会
    • Place of Presentation
      名古屋工業大学、名古屋
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Developement of the Acyclic Pyrimidine Derivative for Selective Cross-linking Reaction to Guanine2012

    • Author(s)
      Shuhei Kusano, Shinya Hagihara, Takuma Moki and Fumi Nagatsugi
    • Organizer
      20th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Synthesis of the Light-Driven Molecular Motors Conjugated with Peptide and Evaluation of the DNA Binding Properties2012

    • Author(s)
      Fumi Nagatsugi,i, Yusuke Takahashi, Maiko Kobayashi and Shunsuke Kuwahara
    • Organizer
      20th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Crosslink Forming Oligonucleotide as a Steric Terminator of Translation2012

    • Author(s)
      Shinya Hagihara, Shuhei Kusano, Nao Iwamoto, Fumi Nagatsugi
    • Organizer
      20th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 糖部修飾による架橋反応性ピリミジン誘導体の反応性制御2012

    • Author(s)
      草野修平、萩原伸也、茂木琢真、永次史
    • Organizer
      第7回日本ケミカルバイオロジー学会
    • Place of Presentation
      京都大学百周年時計台記念館、京都
    • Related Report
      2012 Final Research Report
  • [Presentation] 機能性オリゴ核酸のRNAへの架橋形成による遺伝子発現制御2012

    • Author(s)
      萩原伸也、草野修平、Chao Xio Guang、岩本直生、永次史
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学、神奈川県
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] 糖部修飾型架橋反応性ピリミジン誘導体の合成と評価2012

    • Author(s)
      草野修平、萩原伸也、茂木琢磨、永次史
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of Reactive Oligonucleotides with High Selectivity to a Target Base in RNA2012

    • Author(s)
      Fumi Nagatsugi
    • Organizer
      1st Asian Chemical Biology Initiative
    • Place of Presentation
      Hanoi Vietnam
    • Related Report
      2012 Final Research Report
  • [Presentation] 有機合成化学を基盤とした化学的遺伝子発現制御分子ツールの開発2012

    • Author(s)
      永次 史
    • Organizer
      有機合成化学協会夏季セミナー 明日の有機合成化学
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 反応性核酸誘導体を用いたウイルス複製制御を目指した創薬研究2012

    • Author(s)
      岩本 直生、草野 修平、萩原 伸也、佐々木 要、河治 久実、児玉 栄一、井本 修平、永次 史
    • Organizer
      第12回多元物質科学研究所研究発表会
    • Place of Presentation
      東北大学片平キャンパス・さくらホール、仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞内架橋反応を目指した反応性核酸塩基の開発2012

    • Author(s)
      井田 裕太, 岩本 直生, 草野 修平, 萩原 伸也, 永次 史
    • Organizer
      第12回多元物質科学研究所研究発表会
    • Place of Presentation
      片平キャンパス・さくらホール、仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] 立体配座を固定化した新規架橋反応剤の開発2012

    • Author(s)
      井田 裕太, 岩本 直生, 草野 修平, 萩原 伸也, 永次 史
    • Organizer
      第2回CSJ化学フェスタ2012
    • Place of Presentation
      東京工業大学 大岡山キャンパス、東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 効率的遺伝子発現制御を目指した糖部修飾型架橋反応性ピリミジン誘導体の開発2012

    • Author(s)
      草野 修平、萩原 伸也、茂木 琢真、永次 史、
    • Organizer
      第2回CSJ化学フェスタ2012
    • Place of Presentation
      東京工業大学 大岡山キャンパス、東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 電子吸引基を導入した高活性2-Amino-6-vinylpurine誘導体の開発2012

    • Author(s)
      草野 修平、岩本 直生、萩原 伸也、永次 史
    • Organizer
      第2回アンチセンス&遺伝子デリバリーシンポジウム2012
    • Place of Presentation
      仙台市民会館、仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] 立体配座固定化による反応性向上を目指した新規架橋反応剤の開発2012

    • Author(s)
      井田 裕太, 岩本 直生, 草野 修平, 萩原 伸也, 永次 史
    • Organizer
      第6回バイオ関連化学シンポジウム
    • Place of Presentation
      北海道大学、札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Design of the efficient cross-linking agent with the fixed conformation2012

    • Author(s)
      井田 裕太, 岩本 直生, 草野 修平, 萩原 伸也, 永次 史
    • Organizer
      生体機能関連化学部会 若手の会
    • Place of Presentation
      北海道大学、札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 遺伝子を標的とした新規機能性低分子プローブの開発2012

    • Author(s)
      永次 史
    • Organizer
      天然物ケミカルバイオロジー:分子標的と活性制御 第2回領域公開シンポジウム
    • Place of Presentation
      東京大学弥生講堂、東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 糖部修飾型架橋反応性ピリミジン誘導体の開発2012

    • Author(s)
      草野 修平、萩原 伸也、茂木 琢真、永次 史
    • Organizer
      天然物ケミカルバイオロジー:分子標的と活性制御 第一回若手研究者ワークショップ
    • Place of Presentation
      東京医科歯科大学、東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 糖部修飾による架橋反応性ピリミジン誘導体の反応性制御2012

    • Author(s)
      草野 修平、萩原 伸也、茂木 琢真、永次 史
    • Organizer
      第7回 日本ケミカルバイオロジー学会
    • Place of Presentation
      京都大学 百周年時計台記念館、京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 架橋性PNAオリゴマーの合成2012

    • Author(s)
      石澤悠樹、佐々木 要、萩原伸也、永次 史
    • Organizer
      第23回 万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター、仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthesis of Peptide Nucleic Acid (PNA) Incorporating 4-Amino-6-Oxo-2-Vinylpyrimidine (AOVP)2012

    • Author(s)
      Yuki Ishizawa, Kaname Sasaki, Nao Iwamoto, Shinya Hagihara, Fumi Nagatsugi,
    • Organizer
      The 39th International Symposium on Nucleic Acid Chemistry
    • Place of Presentation
      Nagoya University, Nagoya
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of the Acyclic Pyrimidine Derivative for Selective Cross-linking Reaction to 8-Oxoguanine2012

    • Author(s)
      Shuhei Kusano, Shinya Hagihara and Fumi Nagatsugi
    • Organizer
      he 39th International Symposium on Nucleic Acid Chemistry
    • Place of Presentation
      Nagoya University, Nagoya
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of the Molecular Probes Targeted for Gene2012

    • Author(s)
      Fumi Nagatsugi
    • Organizer
      The 1st International Symposium on Chemical Biology of Natural ProductsTarget ID and Regulation of Bioactivity
    • Place of Presentation
      Kyoto Century Hotel, Kyoto
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of the Intracellular Control of Gene Expression Using Selective Crosslinking Reactions2012

    • Author(s)
      Nao Iwamoto, Shinya Hagihara, Fumi Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School
    • Place of Presentation
      Tohoku University, Sendai
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthesis of Peptide Nucleic Acid (PNA) Incorporating 4-Amino-6-Oxo-2-Vinylpyrimidine2012

    • Author(s)
      Yuki Ishizawa, Kaname Sasaki, Nao Iwamoto, Shinya Hagihara, Fumi Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School
    • Place of Presentation
      Tohoku University, Sendai
    • Related Report
      2012 Annual Research Report
  • [Presentation] Investigation of the Strategy to Selective Chemical Modification for the Nucleobase Opposite the Abasic site2012

    • Author(s)
      Takuma Moki, Kaname Sasaki, Fumi Nagatsugi
    • Organizer
      Tohoku University Campus Asia Program Summer School
    • Place of Presentation
      Tohoku University, Sendai
    • Related Report
      2012 Annual Research Report
  • [Presentation] Revisiting the Interstrand Cross-linking Reaction: PNAs to Oligonulcleotides2012

    • Author(s)
      Yuki Ishizawa, Kaname Sasaki, Nao Iwamoto, Shinya Hagihara, Fumi Nagatsugi
    • Organizer
      The second Asian Chemical Biology Conference ACBC 2012
    • Place of Presentation
      Beach Hotel&Resort Itoman, Okinawa, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of Development of Reactive Oligonucleotides with High Selectivity to a Target Base in RNA2012

    • Author(s)
      Fumi Nagatsugi
    • Organizer
      Asian Chemical Biology Initiative(招待講演)
    • Place of Presentation
      Hanoi, Vietnam
    • Related Report
      2011 Research-status Report
  • [Presentation] 糖部修飾型架橋反応性ピリミジン誘導体の合成と評価2012

    • Author(s)
      草野 修平、 萩原 伸也、茂木琢磨、永次 史
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学、神奈川県
    • Related Report
      2011 Research-status Report
  • [Presentation] 架橋性塩基を導入したPNAオリゴマーの合成および反応性評価2012

    • Author(s)
      石澤悠樹、佐々木 要、萩原伸也、永次 史
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学、神奈川県
    • Related Report
      2011 Research-status Report
  • [Presentation] 架橋反応性核酸を用いた効率的蛋白質発現阻害2012

    • Author(s)
      永次 史、萩原 伸也、草野 修平、井本修平
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学、北海道
    • Related Report
      2011 Research-status Report
  • [Presentation] 6-ビニルプリンによるシトシンへの極めて早いDNA架橋反応2012

    • Author(s)
      井本修平、永次 史、千国友子、寒水壽朗、國枝武久
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学、北海道
    • Related Report
      2011 Research-status Report
  • [Presentation] Evaluation of the Antisense Effects Using the Reactive Oligonucleotides with High Selectivity to the Target Base2011

    • Author(s)
      F. Nagatsugi, T. Hori, S. Kusano, S.Imoto, S. Hagihara, C.H.Guang
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science"
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] 2'-OMe RNA containing 2-amino-6-vinylpurine as a potent gene regulator2011

    • Author(s)
      S. Hagihara, S. Imoto, C. X. Guang, S.Kusano, F. Nagatsugi
    • Organizer
      The 38th International Symposium on NucleicAcids Chemistry
    • Place of Presentation
      Sapporo,Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of Acyclic Nucleoside Analogs with Selective Cross-linking to Guanine2011

    • Author(s)
      S. Kusano, S. Hagihara, T. Moki, F.Nagatsugi
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Sapporo,Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of the Reactive Oligonucleotides with high selective reactivity to a Target Base2011

    • Author(s)
      F. Nagatsugi
    • Organizer
      France-Japan workshop Micro- & Nano- Architectures, Materials & Imaging
    • Place of Presentation
      Bordeaux,France
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞内における遺伝子発現制御を目指した自己活性化架橋反応性核酸の開発2011

    • Author(s)
      永次史、萩原伸也、草野修平、Chao Xiao Guang、茂木琢真
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学、岡山県
    • Related Report
      2012 Final Research Report
  • [Presentation] Dependency of theCross-linking Reactivity with2-Amino-6-vinylpurine on the Neighboring Bases2011

    • Author(s)
      S. Hagihara, S. Kusano, C. X. Guang, F.Nagatsugi
    • Organizer
      7th Anual Meeting of the oligonucleotides theraputic society
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of Cross-linking Agents with Highly Selective Reactivity to a Target Base2011

    • Author(s)
      F. Nagatsugi, S. Hagihara, S. Kusano, C.X. Guang
    • Organizer
      6th Cambridge Symposium on Nucleic Acids Chemistry and Biology
    • Place of Presentation
      Cambridge, United Kingdom
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] 架橋反応性ピリミジン誘導体の合成と評価2011

    • Author(s)
      草野修平、萩原伸也、永次史
    • Organizer
      アンチセンス・遺伝子・デリバリーシンポジウム2011
    • Place of Presentation
      大阪大学、大阪府
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of Selective Cross-linking Reactions and Evaluation of Antisense Effects2011

    • Author(s)
      F. Nagatsugi
    • Organizer
      Gordon Conference on Nucleic Acids
    • Place of Presentation
      University of New England, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 遺伝子変異と老化~化学的ピンポイント遺伝子変異誘導方法を目指したアプローチ2011

    • Author(s)
      永次 史
    • Organizer
      第6回老年医学研究会(招待講演)
    • Place of Presentation
      東北大学、宮城県
    • Related Report
      2011 Research-status Report
  • [Presentation] Evaluation of the Antisense Effects Using the Reactive Oligonucleotides with High Selectivity to the Target Base2011

    • Author(s)
      F. Nagatsugi, T. Hori, S. Kusano, S. Imoto, S. Hagihara, C.H.Guang
    • Organizer
      AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of Acyclic Nucleoside Analogs with Selective Cross-linking to Guanine2011

    • Author(s)
      S. Kusano, S. Hagihara, T. Moki, F. Nagatsugi
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Sapporo,Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] 2’-OMe RNA containing 2-amino-6-vinylpurine as a potent gene regulator2011

    • Author(s)
      S. Hagihara, S. Imoto, C. X. Guang, S. Kusano, F. Nagatsugi
    • Organizer
      The 38th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Sapporo,Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of the Reactive Oligonucleotides with high selective reactivity to a Target Base2011

    • Author(s)
      F. Nagatsugi
    • Organizer
      France-Japan workshop Micro- & Nano- Architectures, Materials & Imaging
    • Place of Presentation
      Bordeaux, France
    • Related Report
      2011 Research-status Report
  • [Presentation] Dependency of the Cross-linking Reactivity with 2-Amino-6-vinylpurine on the Neighboring Bases2011

    • Author(s)
      S. Hagihara, S. Kusano, C. X. Guang, F. Nagatsugi
    • Organizer
      7th Anual Meeting of the oligonucleotides
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2011 Research-status Report
  • [Presentation] 架橋性オリゴ核酸による遺伝子発現制御2011

    • Author(s)
      萩原伸也、井本修平、堀常晃、鈔暁光、永次史
    • Organizer
      第6回日本ケミカルバイオロジー年会
    • Place of Presentation
      東京工業大学大岡山キャンパス、東京都
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of Selective Cross-linking Reactions and Evaluation of Antisense Effects2011

    • Author(s)
      F. Nagatsugi
    • Organizer
      Gordon Conference on Nucleic Acids
    • Place of Presentation
      University of New England USA
    • Related Report
      2011 Research-status Report
  • [Presentation] 架橋反応性ピリミジン誘導体の合成と評価2011

    • Author(s)
      草野 修平、 萩原 伸也、永次 史
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場「エポカルつくば」、茨城県
    • Related Report
      2011 Research-status Report
  • [Presentation] 細胞内における遺伝子発現制御を目指した自己活性化架橋反応性核酸の開発2011

    • Author(s)
      永次 史、 萩原伸也、草野修平、 Chao Xiao Guang、 茂木琢真
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学、岡山県
    • Related Report
      2011 Research-status Report
  • [Presentation] グアニンを標的とした架橋反応性ピリミジン誘導体の開発2011

    • Author(s)
      草野修平、萩原伸也、茂木 琢真、永次史
    • Organizer
      グローバルCOEプログラム 分子系高次構造体化学国際教育研究拠点シンポジウム2011
    • Place of Presentation
      東北大学片平キャンパス・さくらホール、宮城県
    • Related Report
      2011 Research-status Report
  • [Presentation] 6-amino-2-vinylpurine誘導体は架橋反応の詳細を明らかにする2011

    • Author(s)
      草野修平、永次史
    • Organizer
      第14回生命化学研究会
    • Place of Presentation
      南紀白浜、和歌山県
    • Related Report
      2011 Research-status Report
  • [Presentation] 架橋性核酸を用いたmRNAの機能制御2011

    • Author(s)
      萩原伸也、草野修平、岩本直生、Chao Xiao Guang、永次 史
    • Organizer
      第11回多元物質科学研究所研究発表会
    • Place of Presentation
      東北大学片平キャンパス・さくらホール、宮城県
    • Related Report
      2011 Research-status Report
  • [Presentation] 架橋反応性を有する直鎖状ヌクレオシド類縁体の開発2011

    • Author(s)
      草野修平、萩原伸也、茂木 琢真、永次史
    • Organizer
      第11回多元物質科学研究所研究発表会
    • Place of Presentation
      東北大学片平キャンパス・さくらホール、宮城県
    • Related Report
      2011 Research-status Report
  • [Presentation] グリコシル化を鍵反応とした架橋反応性を有するピリミジン誘導体の合成と評価2011

    • Author(s)
      草野修平、萩原伸也、永次史
    • Organizer
      第22回 万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター, 宮城県
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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