Novel Oxidative Synthetic Transformations Driven by Chiral Oxoammmonium Salts
| Project/Area Number |
23659003
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | オキソアンモニウム塩 / アザアダマンタン / 不斉酸化 / アルコール酸化 / 不斉触 媒 / 分子認識 / ニトロキシルラジカル / 酸化反応 / 合成反応 / オキソアンモニウム / 求電子付加 / 精密合成 / 化学選択性 / AZADO |
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| Research Abstract |
Novel synthetic use of azaadamantane-type oxoammonium salts has been exploited. It was found that 9-nor-azaadamantane N-oxy (Nor-AZADO) gives the corresponding oxoammonium salts that exhibit superior activities to AZADO derived oxoammonium salts. Several novel oxidative transformations using Nor-AZADO have been developed including (1) silyl enol ethers to a,b-unsaturated ketones and (2) silyl enol ethers to 1,2-diketones.
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Report
(3 results)
Research Products
(13 results)
