• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Encapsulation of a poorly water-soluble drug with large molecular size into organic nanotube

Research Project

Project/Area Number 23659017
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical pharmacy
Research InstitutionChiba University

Principal Investigator

YAMAMOTO Keiji  千葉大学, 大学院・薬学研究院, 教授 (50110341)

Co-Investigator(Kenkyū-buntansha) MORIBE Kunikazu  千葉大学, 大学院・薬学研究院, 准教授 (50266350)
HIGASHI Kenjirou  千葉大学, 大学院・薬学研究院, 助教 (40451760)
LIMWIKRANT Waree  千葉大学, 大学院・薬学研究院, 助教 (50595907)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords有機ナノチューブ / 難水溶性薬物 / 経口製剤 / 溶解性改善 / 固体分散体 / 非晶質 / 刺激応答性 / 放出制御
Research Abstract

Hydrocortisone (HC) as a poorly water-soluble drug was encapsulated into organic nanotube (ONT), which was formed by self-assembly of N-{12-[(2-α,β-D-glucopyranosyl)carbamoyl]dodecanyl}-glycylglycylglycine acid. The solubility of ONT in acetone was determined as 0.015 mg/mL by solution state1H-NMR spectroscopy, confirming that ONT was poorly-soluble in acetone. Evaporation using acetone was performed to prepare ONTs loaded with HC. Powder X-ray diffraction pattern of evaporated sample with weight ratio of HC/ONT=3/7 showed a hallo pattern without remained peaks of crystalline HC. <13>^C-solid state NMR measurements demonstrated that HC peaks became broadened in a spectrum of evaporated sample, compared with those of HC crystal. These results indicated thatHC was encapsulated in ONT as amorphous state.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Yellow coloration phenomena of incorporated indomethacin into folded sheet mesoporous materials2012

    • Author(s)
      S. Tanabe, K. Higashi, M. Umino, W. Limwikrant, K. Yamamoto, K. Moribe
    • Journal Title

      Int. J. Pharm

      Volume: 429 Pages: 38-45

    • Related Report
      2012 Final Research Report
  • [Journal Article] Yellow coloration phenomena of incorporated indomethacin into folded sheet mesoporous materials2012

    • Author(s)
      S.Tanabe
    • Journal Title

      International Journal of Pharmaceutics

      Volume: (印刷中) Issue: 1-2 Pages: 38-45

    • DOI

      10.1016/j.ijpharm.2012.03.011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 混合粉砕によるpiroxicamのPEG/・-CD-polypseudorotaxaneへの封入2012

    • Author(s)
      並木祥恵、WareeLimwikrant、東顕二郎、森部久仁一、山本恵司
    • Organizer
      第29回シクロデキストリンシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 混合粉砕と加熱によるCD-polypseudorotaxane同士で形成される空間への薬物封入2012

    • Author(s)
      並木祥恵、WareeLimwikrant、東顕二郎、森部久仁一、山本恵司
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      兵庫
    • Related Report
      2012 Final Research Report
  • [Presentation] 有機ナノチューブを用いたヒドロコルチゾンの溶解性改善2012

    • Author(s)
      牧島隆史、東顕二郎、WareeLimwikrant、森部久仁一、丁武考、増田光俊、清水敏美、山本恵司
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道
    • Related Report
      2012 Final Research Report
  • [Presentation] FSM細孔内のインドメタシン着色メカニズムの検討2012

    • Author(s)
      東顕二郎、田邉修一、WareeLimwikrant、森部久仁一、山本恵司
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道
    • Related Report
      2012 Final Research Report
  • [Presentation] 混合粉砕によるpiroxicamのPEG/&#61543;-CD-polypseudorotaxaneへの封入2012

    • Author(s)
      並木祥恵、Waree Limwikrant、東顕二郎、森部久仁一、山本恵司
    • Organizer
      第29回シクロデキストリンシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 混合粉砕と加熱によるCD-polypseudorotaxane 同士で形成される空間への薬物封入2012

    • Author(s)
      並木祥恵、Waree Limwikrant、東顕二郎、森部久仁一、山本恵司
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      兵庫
    • Related Report
      2012 Annual Research Report
  • [Presentation] 有機ナノチューブを用いたヒドロコルチゾンの溶解性改善2012

    • Author(s)
      牧島隆史
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学、北海道
    • Related Report
      2011 Research-status Report
  • [Presentation] FSM細孔内のインドメタシン着色メカニズムの検討2012

    • Author(s)
      東顕二郎
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学、北海道
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.p.chiba-u.ac.jp/lab/seizai/index.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi