Role of host proton-sensing receptors in tumorigenesis: analysis with receptor-deficient mice
| Project/Area Number |
23659029
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プロトン感知性受容体 / TDAG8 / 細胞外 pH / 腫瘍 / マクロファージ / プロトン受容体 / がん |
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| Research Abstract |
It is well known that tumorigenesis is accompanied by extracellular acidification. However, the role of acidification remains unknown. Here, we investigated the role of recently identified proton-sensing receptors by using their receptor-deficient mice. Our results suggested that proton-sensing receptors are involved in tumorigenesis andextracellular acidification changes the M1-M2 macrophage phenotype.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Deficiency of Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1Attenuates Glucose-Stimulated Insulin Secretion2012
Author(s)
Nakakura T, Mogi C, Tobo M, Tomura H, Sato K, Kobayashi M, Ohnishi H, Tanaka S, Wayama M, Sugiyama T, Kitamura T, Harada A, and Okajima F.
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Journal Title
Endocrinology
Volume: 153
Pages: 4171-4180
Related Report
Peer Reviewed
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[Journal Article] An orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasionand metastasis in vivo2012
Author(s)
Komachi M, Sato K, Tobo M, Mogi C, Yamada T, Ohta H, Tomura H, Kimura T, Im DS, Yanagida K, Ishii S, Takeyoshi I, and Okajima F.
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Journal Title
Cancer Sci
Volume: 103
Pages: 1099-1104
Related Report
Peer Reviewed
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[Journal Article] Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells2011
Author(s)
Matsuzaki S, Ishizuka T, Yamada H, Kamide Y, Hisada T, Ichimonji I, Aoki H, Yatomi M, Komachi M, Tsurumaki H, Ono A, Koga Y, Dobashi K, Mogi C, Sato K, Tomura H, Mori M, and Okajima F.
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Journal Title
Biochem Biophys Res Commun
Volume: 413
Pages: 499-503
Related Report
Peer Reviewed
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