| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Caspases are evolutionary conserved cystein protease. In this study, we tried to reveal dynamics of caspase activation in maintaining brain homeostasis. For this purpose, we utilized two novel probes that allow us to detect caspases-1 or caspase-3 in real-time. However, we have not detected weak or mild activation of those caspases in the brain derived from sleep-deprived mouse or in primary cell culture. These results suggest that further improvement in detection method will be needed to observe weak or mild activation of caspases by these probes.
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