Analysis of the molecular mechanism of flip-flop that regulates the asymmetric distribution of lipids in the plasma membranes
| Project/Area Number |
23659047
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HASEGAWA Akiko 独立行政法人理化学研究所, 小林脂質生物学研究室, 専任研究員 (20332314)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | フリップ / フロップ / ホスファチジルセリン / 脂質動態 / 形質膜 / 非対称分布 / 変異株 / フリップ・フロップ |
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| Research Abstract |
An adaptor protein was identified as the responsible factor of the mutant which was thought to have a defect of flip-flop machinery. The results of the RNAi experiment suggested the possibility that the adaptor protein contributes to the regulation of transbilayer movement of phosphatidylserine at the plasma membranes. I tried to identify the molecules which take part in the flip-flop machinery in cooperation with the adaptor protein. However, it has not succeeded yet. I also analyzed the signaling pathway involved in flip-flop machinery, and the relationship between flip-flop and cytoskeleton was implied.
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Report
(3 results)
Research Products
(4 results)
