| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
An adaptor protein was identified as the responsible factor of the mutant which was thought to have a defect of flip-flop machinery. The results of the RNAi experiment suggested the possibility that the adaptor protein contributes to the regulation of transbilayer movement of phosphatidylserine at the plasma membranes. I tried to identify the molecules which take part in the flip-flop machinery in cooperation with the adaptor protein. However, it has not succeeded yet. I also analyzed the signaling pathway involved in flip-flop machinery, and the relationship between flip-flop and cytoskeleton was implied.
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