| Project/Area Number |
23659051
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
FUJII Shinya 東京医科歯科大学, 生体材料工学研究所, 助教 (60389179)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | ビタミンK / メナキノン / 酸化誘導体 / 癌細胞 / 増殖抑制 / 抗炎症効果 / 細胞増殖 / 抗炎症作用 / メナキノン-4 / K acid I / K acid II / HepG2細胞 / 核内受容体 / SXR / 抗腫瘍活性 |
|---|
| Research Abstract |
Recently, novel biological properties of vitamin K, including function as some nuclear receptor ligand and inhibitory activity of cancer cell proliferation. In this study, we examined to develop novel vitamin K derivatives in order to clarify the detailed biological functions of vitamin K and to apply them to clinical utility. Based on our hypothesis that vitamin K (menaquinones) would be metabolized to yield an active substance for some vitamin K functions, we designed the derivatives bearing an polar functional group at the terminal of the side chain. As a result, we developed the efficient synthetic method for vitamin K metabolites, K acid I and II, and synthesized systematically the oxidative derivatives of vitamin K with various length of the side chain. Some of these novel derivatives inhibited the proliferation of some cancer cells in vitro, and showed anti-inflammatory effects in vivo.
|
