| Project/Area Number |
23659053
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
OHTA Shigeru 広島大学, 大学院・医歯薬保健学研究院, 教授 (60160503)
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| Co-Investigator(Kenkyū-buntansha) |
SANOH Seigo 広島大学, 大学院・医歯薬保健学研究院, 助教 (00552267)
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| Research Collaborator |
FUJIMOTO Mami 広島大学, 薬学部, 学生
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 薬学 / ヒト肝細胞移植キメラマウス / 肝細胞 / 薬物代謝酵素 / 遺伝多型 / 薬物動態 / 遺伝子多型 |
|---|
| Research Abstract |
Recently, intra-individual differences of drug metabolism and pharmacokinetics caused by the polymorphism of drug metabolic enzymes have been concerned in drug development. It is difficult to use drugs which show interindividual differencesbecause these result in changes of efficacy and safety. We used chimeric mice transplanted with human donor hepatocytes to examine whether chimeric mice reflect drug metabolism and pharmacokinetics of donors. In the results, it is possible to become useful models to predict interindividual differences of drug metabolism and pharmacokinetics.
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