| Project/Area Number |
23659058
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UMEZAWA Naoki 名古屋市立大学, 大学院・薬学研究科, 准教授 (40347422)
KATO Nobuki 名古屋市立大学, 大学院・薬学研究科, 助教 (50400221)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 抗ガン活性 / プロドラッグ / トポロジー / カテナン / ロタキサン / ケージド化合物 / 大環状化合物 / 生理活性物質 / 超分子 / 創薬手法 / 抗ガン活性化合物 |
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| Research Abstract |
This research project aims development of new methodology for controlling the activity of bioactive compound by introducing catenane or rotaxane structure that is removable under a certain condition. We have mainly deal with catenane structure. We examined construction of catenane between a macrocyclic model compoundand macrocyclic disulfide of which S-S bond is cleavable under reductive condition. We have succeeded in the improvement of macrocyclic disulfide structure for efficient catenane synthesis.
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