New Strategy for Controlling Activity of Bioactive Compounds by Introduction of Catenane or Rotaxane Structure
Project/Area Number |
23659058
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Drug development chemistry
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Research Institution | Nagoya City University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
UMEZAWA Naoki 名古屋市立大学, 大学院・薬学研究科, 准教授 (40347422)
KATO Nobuki 名古屋市立大学, 大学院・薬学研究科, 助教 (50400221)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 抗ガン活性 / プロドラッグ / トポロジー / カテナン / ロタキサン / ケージド化合物 / 大環状化合物 / 生理活性物質 / 超分子 / 創薬手法 / 抗ガン活性化合物 |
Research Abstract |
This research project aims development of new methodology for controlling the activity of bioactive compound by introducing catenane or rotaxane structure that is removable under a certain condition. We have mainly deal with catenane structure. We examined construction of catenane between a macrocyclic model compoundand macrocyclic disulfide of which S-S bond is cleavable under reductive condition. We have succeeded in the improvement of macrocyclic disulfide structure for efficient catenane synthesis.
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Report
(3 results)
Research Products
(41 results)
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[Journal Article] Effect of Helical Conformation and Side-Chain Structure on y-Secretase Inhibition by β-Peptide Foldamers : Insight into Substrate Recognition2013
Author(s)
Yuki Imamura, Naoki Umezawa, Satoko Osawa, Naoaki Shimada, Takuya Higo, Satoshi Yokoshima, Tohru Fukuyama, Takeshi Iwatsubo, Nobuki Kato, Taisuke Tomita, Tsunehiko Higuchi
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Journal Title
J. Med. Chem.
Volume: 56
Issue: 4
Pages: 1443-1454
DOI
Related Report
Peer Reviewed
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[Book] 無機化学2011
Author(s)
樋口恒彦 その他(青木 伸 編)
Total Pages
211
Publisher
化学同人
Related Report
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