Basic study for system of automatic affinity enhancement of specificprotein-protein interaction
| Project/Area Number |
23659065
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
SHOJI Shozo 熊本大学, 生命科学研究部, 名誉教授 (60040317)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 微生物 / 感染症学 / 相互作用 |
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| Research Abstract |
Specific protein-protein binding/interaction is very useful, by which specific detectionof a protein by using an antibody, regulation of specific protein function by dominantnegative effect of the mutated protein, and so on become available. The purpose of thisstudy is to collect basic data and resources for establishment of the system, which canautomatically enhance affinity of Intended specific protein-protein binding. It wasplaned to utilize a viral property of high mutagenisity for the system. Although we couldnot proceed enough as we had planed at the beginning of the study, we used many experiencesobtained by this study for following future study.
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Report
(3 results)
Research Products
(11 results)
