| Project/Area Number |
23659068
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Sachiko 昭和大学, 薬学部, 講師 (00197419)
ASHINO Takashi 昭和大学, 薬学部, 助教 (00338534)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ガス状物質 / 一酸化炭素 / 硫化水素 / Nrf2 / 肝傷害 / 動脈硬化 / 血管平滑筋細胞 |
|---|
| Research Abstract |
Physiologically produced gaseous substances such as carbon monoxide, hydrogen sulfide, and nitric oxide have been assumed to play roles in controlling biological functions.In the present study, we examined up-regulation of gaseous substance-generating enzymes by xenobiotics and biologic factors, and its roles in disease developments. An oxidative stress inducer, a physiological antioxidant, and a growth factor induced carbon monoxideand heydrogen sulfide-generating enzymes. Furthermore, we have uncovered possible roles of these enzymes in inhibiting liver injury and arteriosclerosis.
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