| Project/Area Number |
23659070
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Aki 東北大学, 大学院・薬学研究科, 助手 (30545695)
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|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 薬物動態 / 代謝学 / CYP2D6 / ファーマコゲノミクス |
|---|
| Research Abstract |
We examined changes in the protein expression of the drug-metabolizing enzyme CYP2D6 by using an assay capable of analyzing the influence of intron SNPs, to determine the individual differences in protein activity that cannot be explained by exon SNPs alone. As a result, we found that while the positive control CYP2D6*41 showed a 35% decrease in protein expression compared to the wild-type CYP2D6*1, none of the other 4 variants differed greatly from the wild-type.
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