| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In this research, it is shown that cytochrome P450 is expressed in silkworm midgut and most of compounds, metabolized by cytochrome P450 in mammals, were also metabolized in silkworm midgut. The transgenic silkworm expressing human cytochrome P450 could metabolize the compound that was not metabolized in wild-type silkworm. These results further entrenched usefulness of silkworm as a model animal for drug discovery.
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