Evaluation of pharmacokinetic using silkworm as an animal model
| Project/Area Number |
23659074
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | カイコ / 薬物動態 / シトクローム P450 / 抗生物質 / シトクロームP450 |
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| Research Abstract |
In this research, it is shown that cytochrome P450 is expressed in silkworm midgut and most of compounds, metabolized by cytochrome P450 in mammals, were also metabolized in silkworm midgut. The transgenic silkworm expressing human cytochrome P450 could metabolize the compound that was not metabolized in wild-type silkworm. These results further entrenched usefulness of silkworm as a model animal for drug discovery.
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Report
(3 results)
Research Products
(22 results)
