Novel strategy of drug therapy for inflammatory bowel diseases based on the combination of drug transport and intestinal immunology.
Project/Area Number |
23659077
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
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Research Institution | Shiga University of Medical Science |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
ANDOH Akira 滋賀医科大学, 大学院・医学系研究科, 教授 (90252395)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 薬学 / 薬剤反応性 / 薬理学 / 薬物トランスポータ / 炎症性腸疾患 |
Research Abstract |
Expression of peptide transporter PEPT1 in the large intestine of inflammatory bowel disease (IBD) patients was specifically induced in the inflammatory region. Furthermore, this expression was suggested to be stimulated by intestine-specific transcription factor CDX2. Based on the literature and molecular design methods, eight kinds of amino acid derivatives of 5-aminosalicylic acid were synthesized, which can become the substrates for PEPT1. The interaction of PEPT1 with these amino acid derivatives of 5-aminosalicylic acid will be evaluated from the view points of in vitro and in vivo.
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Report
(3 results)
Research Products
(33 results)
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[Journal Article] Neutralization of complement component C5 ameliorates the development of dextran sulfate sodium (DSS)-colitis in mice2013
Author(s)
Aomatsu T, Imaeda H, Takahashi K, Fujimoto T, Kasumi E, Ban H, Bamba S, Yoden A, Tamai H, Fujiyama Y, Andoh A.
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 52
Issue: 1
Pages: 72-75
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed
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[Journal Article] Renal tubular secretion of varenicline by multidrug and toxin extrusion (MATE) transporters.2012
Author(s)
Kajiwara, M., Masuda, S., Watanabe, S., Terada, T., Katsura, T. and Inui, K.
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Journal Title
Drug Metab. Pharmacokinet.
Volume: 27(6)
Pages: 563-569
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] The severity of dextran sodium sulfate-induced colitis can differ between dextran sodium sulfate preparations of the same molecular weight range2012
Author(s)
Bamba, S., Andoh, A., Ban, H., Imaeda, H., Aomatsu, T., Kobori, A., Mochizuki, Y., Shioya, M., Nishimura, T., Inatomi, O., Sasaki, M., Saitoh, Y., Tsujikawa, T., Araki, Y. and Fujiyama, Y.
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Journal Title
Dig. Dis. Sci
Volume: 57(2)
Issue: 2
Pages: 327-334
DOI
Related Report
Peer Reviewed
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[Journal Article] Interleukin-33 suppresses Notch ligand expression and prevents goblet cell depletion in dextran sulfate sodium-induced colitis2011
Author(s)
Imaeda, H., Andoh, A., Aomatsu, T., Uchiyama, K., Bamba, S., Tsujikawa, T., Naito, Y. and Fujiyama, Y.
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Journal Title
Int. J. Mol. Med.
Volume: 28(4)
Pages: 573-578
DOI
Related Report
Peer Reviewed
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