Development of transcutaneous vaccine with efficacy and safety for the overcoming infectious diseases

• Project/Area Number: 23659078
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Osaka University
• Principal Investigator: TSUTSUMI Yasuo 大阪大学, 大学院・薬学研究科, 教授 (50263306)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 医療薬剤学 / ナノメディシン / ドラッグデリバリーシステム / ワクチン / 安全 / ナノ / 経皮ワクチン / 安全性 / 毒性 / 感染症 / ナノマテリアル

Research Abstract

Nanomaterials have superior functions, so it is expected that they will play an active part in medicine, such as drug delivery system carrier, vaccine carrier, and so on. In the study, I have tried to develop transcutaneous vaccine with efficacy and safety by using amorphous nanosilica particles. I believe that the study will provide the basic information for the establishment of safer and effective nano-vaccine.

Research Products

• [Journal Article] Dermal absorption of amorphous nanosilica particles after topical exposure for three days (2012)
  • Author(s): Hirai T., Yoshikawa T., Nabeshi H., Yoshida T., Tochigi S., Uji M., Ichihashi K., Akase T., Nagano K., Abe Y., Kamada H., Tsunoda S., Yoshioka Y., Itoh N., Tsutsumi Y.
  • Journal Title: Pharmazie. Volume: 67(8) Pages: 742-3
• [Journal Article] Amorphous silica nanoparticles enhance cross-presentation in murine dendritic cells (2012)
  • Author(s): Hirai T., Yoshioka Y., Takahashi H., Ichihashi K., Yoshida T., Tochigi S., Nagano K., Abe Y., Kamada H., Tsunoda S., Nabeshi H., Yoshikawa T., Tsutsumi Y.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 427(3) Pages: 553-6
• [Journal Article] Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection (2012)
  • Author(s): Hirai T., Yoshikawa T., Nabeshi H., Yoshida T., Tochigi S., Ichihashi K., Uji M., Akase T., Nagano K., Abe Y., Kamada H., Itoh N., Tsunoda S., Yoshioka Y., Tsutsumi Y
  • Journal Title: Part. Fibre. Toxicol Volume: 9(1) Pages: 3-3
• [Journal Article] Dermal absorption of amorphous nanosilica particles after topical exposure for three days (2012)
  • Author(s): Toshiro Hirai
  • Journal Title: Pharmazie Volume: 67 Pages: 742-3
  • Peer Reviewed
• [Journal Article] Amorphous silica nanoparticles erinance cross-presentation in murine dendritic cells. (2012)
  • Author(s): 平井敏郎
  • Journal Title: Biochem Biophys Res Commun. Volume: 427 Issue: 3 Pages: 553-6
  • DOI: 10.1016/j.bbrc.2012.09.095
  • Peer Reviewed
• [Journal Article] Part Fibre Toxicol (2012)
  • Author(s): Hirai T, Yoshikawa T, Nabeshi H, Yoshida T, Tochigi S, Ichihashi K, Uji M, Akase T, Nagano K, Abe Y, Kamada H, Itoh N, Tsunoda S, Yoshioka Y, Tsutsumi Y.
  • Journal Title: Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection Volume: 9:3 Issue: 1 Pages: 1-11
  • DOI: 10.1186/1743-8977-9-3
  • Peer Reviewed
• [Presentation] 非晶質ナノシリカ介在性クロスプレゼンテーション誘導機構の解明に向けて (2012)
  • Author(s): 高橋秀樹, 吉岡靖雄, 平井敏郎, 市橋宏一, 角田慎一, 鍋師裕美, 吉川友章, 堤康央
  • Organizer: 第62回日本薬学会近畿支部総会・大会
  • Place of Presentation: 西宮(兵庫)
• [Presentation] プロテインコロナの制御による新規ナノワクチンの安全設計 (2012)
  • Author(s): 宇高麻子, 吉岡靖雄, 吉田徳幸, 宇治美由紀, 三里一貴, 森 宣瑛, 山口真奈美, 角田慎一, 鍋師裕美, 吉川友章, 堤 康央
  • Organizer: 第62回日本薬学会近畿支部総会・大会
  • Place of Presentation: 西宮(兵庫)
• [Presentation] 非晶質ナノシリカ介在性クロスプレゼンテーション誘導機構の解明に向けて
  • Author(s): 髙橋秀樹
  • Organizer: 第62回日本薬学会近畿支部総会・大会
  • Place of Presentation: 兵庫
• [Presentation] プロテインコロナの制御による新規ナノワクチンの安全設計
  • Author(s): 宇髙麻子
  • Organizer: 第62回日本薬学会近畿支部総会・大会
  • Place of Presentation: 兵庫
• [Remarks]
  • URL: http://www.phs.osaka-u.ac.jp/homepage/b009/