| Project/Area Number |
23659083
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
IEIRI Ichiro 九州大学, 薬学研究院, 教授 (60253473)
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Takeshi 九州大学, 薬学研究院, 助教 (80423573)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | オーダーメード医療 / MDR1 / CYP3A4 / DMR / コヒーシン / コヒーシンモデル |
|---|
| Research Abstract |
Human intestinal CYP3A4 and ABCB1 mRNA expression levels showed large inter-individual differences and a significant association between them. The CpG island located in the region between CYP3A4and ABCB1 genes locus were analyzed by bisulfite sequencing method. Some CG sites (No. 14-18) were partially demethylated in human intestinal samples. Since these regions include CTCF binding regions, demethylation in the CG sites (No. 14-18) are suggested to be important for cohesion mediating transcriptional insulationin CYP3A4 and ABCB1 gene locus.
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