Role of molecular clock on the communication between each organ in organ dysfunction

Research Project

Project/Area Number	23659084
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Medical pharmacy
Research Institution	Kyushu University
Principal Investigator	OHDO Shigehiro 九州大学, 大学院・薬学研究院, 教授 (00223884)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	生体リズム / 分子時計 / 臓器障害 / 合併症
Research Abstract	Chronic kidney disease (CKD) increases the disease risk of apoplexy, cardiac failure, cardiac infarction and neurological complications. However, the mechanisms of these neurological complications remain unclear. Here, we showed the disruptive effect of chronic renal failure in 5/6 nephrectomy mice on the 24-hr rhythm of dopamine receptor and clock gene expressions in the striatum and cytochrome P450 (CYPs) in liver. These disruptive effects were induced by abnormal signal transduction in high Factor X expression from the kidney.