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A physiological role of a novel gaseous mediator hydrogen sulfide

Research Project

Project/Area Number 23659089
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

KIMURA Hideo  独立行政法人国立精神・神経医療研究センター, 神経研究所 神経薬理研究部, 部長 (30321889)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords硫化水素 / ポリサルファイド / D-システイン / 生理活性物質 / 生産酵素 / 網膜保護 / 補酵素 / 蛍光プローブ
Research Abstract

Hydrogen sulfide (H2S) is recognized as a physiological mediator, and its roles and therapeutic applications have been studied. In the present study we examined 1. the regulation of producing enzymes, especially focusing on their co-enzymes and co-factors, 2. the protection of the retina from intensive light-induced degeneration, 3. the idenfitication of H2S-sensitive molecules, 4. a role as an endothelium-derived relaxing factor, 5. the development of H2S imaging probes.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (127 results)

All 2014 2013 2012 2011 Other

All Journal Article (31 results) (of which Peer Reviewed: 27 results) Presentation (88 results) (of which Invited: 17 results) Book (4 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] The physiological role of hydrogen sulfide and beyond2014

    • Author(s)
      Kimura, H
    • Journal Title

      Nitric Oxide

      Volume: (in press) Pages: 4-10

    • DOI

      10.1016/j.niox.2014.01.002

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Production and physiological effects of hydrogen sulfide2014

    • Author(s)
      Kimura, H.
    • Journal Title

      Antioxid. Redox Signal

      Volume: 20 Issue: 5 Pages: 783-793

    • DOI

      10.1089/ars.2013.5309

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells2013

    • Author(s)
      Shibuya N, Koike S, Tanaka M, Ishigami-Yuasa M, Kimura Y, Ogasawara Y, Fukui K, Nagahara N, Kimura H
    • Journal Title

      Nat Commun.

      Volume: 4 Issue: 1 Pages: 1366-1366

    • DOI

      10.1038/ncomms2371

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide is produced by cystathionine gamma-lyase at the steady-state low intracellular Ca2+ concentrations2013

    • Author(s)
      Mikami Y, Shibuya N, Ogasawara Y, Kimura H.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 431 Issue: 2 Pages: 131-135

    • DOI

      10.1016/j.bbrc.2013.01.010

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Polysulfides are possible H_2S-derived signaling molecules in rat brain.2013

    • Author(s)
      Yuka Kimura, Yoshinori Mikami, Kimiko Osumi, Mamiko Tsugane, Junichiro Oka, Hideo Kimura
    • Journal Title

      FASEB Journal

      Volume: 27 Issue: 6 Pages: 2451-2457

    • DOI

      10.1096/fj.12-226415

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Production of hydrogen sulfide from D-cysteine and its therapeutic potential.2013

    • Author(s)
      Shibuya N, Kimura H.
    • Journal Title

      Frontiers in Endocrinology

      Volume: Article 87 Pages: 1-5

    • DOI

      10.3389/fendo.2013.00087

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nutritional essentiality of sulfur in health and disease2013

    • Author(s)
      Ingenbleek, Y., Kimura, H
    • Journal Title

      Nutr

      Volume: Rev. 71 Issue: 7 Pages: 413-432

    • DOI

      10.1111/nure.12050

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physiological role of hydrogen sulfide and polysulfide in the central nervous system2013

    • Author(s)
      Kimura, H
    • Journal Title

      Neurochem. Int

      Volume: 63 Issue: 5 Pages: 492-497

    • DOI

      10.1016/j.neuint.2013.09.003

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide-mediated cellular signaling and cytoprotection2013

    • Author(s)
      Kimura, H
    • Journal Title

      Hydrogen Sulfide and its Therapeutic Applications, Springer Wien Heidelberg New York Dordrecht London

      Pages: 181-202

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells2013

    • Author(s)
      Koike S, Ogasawara Y, Shibuya N, Kimura H, Ishii K.
    • Journal Title

      FEBS Lett.

      Volume: 587 Issue: 21 Pages: 3548-3555

    • DOI

      10.1016/j.febslet.2013.09.013

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 硫化水素(H2S)の生理機能と医療応用2013

    • Author(s)
      木村英雄
    • Journal Title

      生化学

      Volume: 85 Pages: 63-75

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 生理活性物質硫化水素(H2S)の医療応用2013

    • Author(s)
      木村由佳、木村英雄
    • Journal Title

      医薬品医療機器レギュラトリーサイエンス

      Volume: 44 Pages: 190-199

    • Related Report
      2012 Research-status Report
  • [Journal Article] 生理活性物質としての硫化水素2013

    • Author(s)
      渋谷典広、木村英雄
    • Journal Title

      Dojin News

      Volume: 146 Pages: 1-6

    • Related Report
      2012 Research-status Report
  • [Journal Article] Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionine γ-lyase in the pancreatic β-cell2012

    • Author(s)
      Taniguchi S, Kimura T, Umeki T, Kimura Y, Kimura H, Ishii I, Itoh N, Naito Y, Yamamoto H, Niki I
    • Journal Title

      Mol.Cell.Endocrinol.

      Volume: 350 Issue: 1 Pages: 31-38

    • DOI

      10.1016/j.mce.2011.11.016

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic turnover of hydrogen sulfide2012

    • Author(s)
      Kimura, H
    • Journal Title

      Frontiers in Physiology

      Volume: 3(article 101) Pages: 1-3

    • DOI

      10.3389/fphys.2012.00101

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide is a signaling molecule and a cytoprotectant2012

    • Author(s)
      Kimura H, Shibuya N, Kimura Y.
    • Journal Title

      Antioxid Redox Signal

      Volume: 17(1) Issue: 1 Pages: 45-47

    • DOI

      10.1089/ars.2011.4345

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhaled hydrogen sulfide prevents endotoxin-induced systemic inflammation and improves survival by altering sulfide metabolism in mice2012

    • Author(s)
      Tokuda, K., Kida, K., Marutani, E., Crimi, E., Bougaki, M., Khatri, A., Kimura, H., and Ichinose, F
    • Journal Title

      Antioxid. Redox Signal

      Volume: 17 Issue: 1 Pages: 11-21

    • DOI

      10.1089/ars.2011.4363

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A mechanism of retinal protection from light-induced degeneration by hydrogen sulfide2012

    • Author(s)
      Mikami, Y., and Kimura, H
    • Journal Title

      Commun Integr. Biol

      Volume: 5 Issue: 2 Pages: 169-171

    • DOI

      10.4161/cib.18679

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 硫化水素(H2S)の基礎2012

    • Author(s)
      渋谷典広、木村英雄
    • Journal Title

      LiSA

      Volume: 19 Pages: 1284-1289

    • Related Report
      2012 Research-status Report
  • [Journal Article] 硫化水素:生合成、放出、生理機能2012

    • Author(s)
      木村英雄
    • Journal Title

      日薬理誌

      Volume: 139 Pages: 6-8

    • NAID

      10030455931

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A mechanism of retinal protection from light-induced degeneration by hydrogen sulfide2012

    • Author(s)
      Yoshinori Mikami, Hideo Kimura
    • Journal Title

      Commun. Integr. Biol.

      Volume: 5 Pages: 169-171

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ガス性分子による臓器保護―硫化水素を中心として2012

    • Author(s)
      木村英雄
    • Journal Title

      Medical Gases Information Files

      Volume: 11 Pages: 4-11

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A mechanism of retinal protection from light-induced degeneration by hydrogen sulfide.2012

    • Author(s)
      Mikami Y and Kimura H.
    • Journal Title

      Communicative & Integrative Biology

      Volume: 5 Pages: 1-3

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide: production, release, and functions2012

    • Author(s)
      木村英雄
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 139 Issue: 1 Pages: 6-8

    • DOI

      10.1254/fpj.139.6

    • NAID

      10030455931

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2011 Research-status Report
  • [Journal Article] The neurophysiology of hydrogen sulfide2011

    • Author(s)
      Rong, W., Kimura, H., and Grundy, D
    • Journal Title

      Inflamm Allergy Drug Targets

      Volume: 10 Issue: 2 Pages: 109-117

    • DOI

      10.2174/187152811794776295

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide : its production, release and functions2011

    • Author(s)
      Kimura, H
    • Journal Title

      Amino Acids.

      Volume: 41 Issue: 1 Pages: 113-121

    • DOI

      10.1007/s00726-010-0510-x

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide : Its production and functions2011

    • Author(s)
      Kimura, H
    • Journal Title

      Exp. Physiol

      Volume: 96 Pages: 833-835

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide2011

    • Author(s)
      Mikami Y, Shibuya N, Kimura Y, Nagahara N, Ogasawara Y, Kimura H
    • Journal Title

      Biochem J.

      Volume: 1;439(3) Issue: 3 Pages: 479-85

    • DOI

      10.1042/bj20110841

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a highly selective fluorescence probe for hydrogen sulfide2011

    • Author(s)
      Sasakura K, Hanaoka K, Shibuya N, Mikami Y, Kimura Y, Komatsu T, Ueno T, Terai T, Kimura H, Nagano T
    • Journal Title

      Journal of the American Chemical Society

      Volume: 133(45) Issue: 45 Pages: 18003-18005

    • DOI

      10.1021/ja207851s

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide protects the retina from light-induced degeneration by the modulation of Ca2+ influx.2011

    • Author(s)
      Mikami Y, Shibuya N, Kimura Y, Nagahara N, Yamada M, Kimura H.
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Pages: 39379-39386

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide: its production and functions.2011

    • Author(s)
      Kimura H.
    • Journal Title

      Experimental Physiology

      Volume: 96 Issue: 9 Pages: 833-835

    • DOI

      10.1113/expphysiol.2011.057455

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells2014

    • Author(s)
      Shibuya, N., Koike, S., Ishigami-Yuasa, M., Tanaka, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nagahara, N., Kimura, H
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2014-03-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Polysulfides are potential H2S-derived signaling molecules that activate TRPA1 channels in rat brain2014

    • Author(s)
      Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I., Kimura, H
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター, 仙台
    • Year and Date
      2014-03-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Hydrogen sulfide protects retina from light-induced degeneration2014

    • Author(s)
      Kimura, H., Mikami, Y., Shibuya, N., Kimura, Y., Nagahara, N., Yamada, M
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2014-03-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 生理活性物質H2S の新規生産経路2013

    • Author(s)
      渋谷 典広, 小池 伸, 湯浅(石上) 磨里, 田中 真紀子, 木村 由佳, 小笠原 裕樹, 福井 清, 永原 則之, 木村 英雄
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド, 神戸
    • Year and Date
      2013-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 硫化水素(H_2S)の生合成と機能2013

    • Author(s)
      木村英雄
    • Organizer
      第24回フォーラム イン ドージン生体硫化水素(bioH_2S)-原始環境が用意したシグナル分子-
    • Place of Presentation
      熊本ホテルキャッスル, 熊本
    • Year and Date
      2013-11-15
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Polysulfides are possible H_2S-derived signaling molecules in rat brain2013

    • Author(s)
      Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I., Kimura, H
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Year and Date
      2013-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 生理活性物質としての硫化水素(H_2S)2013

    • Author(s)
      木村英雄
    • Organizer
      第9回Heme Oxytenase 研究フォーラム
    • Place of Presentation
      京都府立医科大学・青蓮会館, 京都
    • Year and Date
      2013-08-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of H2S production by cystathionine gamma-lyase by calcium2013

    • Author(s)
      Kimura, H, Mikami, Y., Shibuya, N., Ogasawara, Y
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto International Conference Center, Kyoto.
    • Year and Date
      2013-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells2013

    • Author(s)
      Shibuya, N., Koike, S., Tanaka, M., Ishigami-Yuasa, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nahahara, N., Kimura, H
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Signaling mechanism of hydrogen sulfide in astrocytes2013

    • Author(s)
      Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I., Kimura, H
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 硫化水素選択的蛍光プローブの開発とその応用2013

    • Author(s)
      篠倉 潔, 花岡健二郎, 渋谷典広, 木村英雄, 長野哲雄
    • Organizer
      日本薬学会 第133年会
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Year and Date
      2013-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 硫化水素は, 神経細胞における硫化水素の細胞保護作用;グルタチオンの産生の増大と, ミトコンドリアにおける酸化的ストレスの抑制2013

    • Author(s)
      木村由佳, 後藤雄一, 木村英雄
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 硫化水素(H_2S)の生合成と光障害からの視神経保護2013

    • Author(s)
      木村英雄, 三上義礼, 渋谷典広, 木村由佳, 永原則之, 山田雅弘
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Open Plenary : Physiological function of hydrogen sulfide and beyond2013

    • Author(s)
      Kimura, H
    • Organizer
      The 2nd European Conference on the Biology of Hydrogen Sulfide
    • Place of Presentation
      Exeter University Convention Center, Exeter, UK
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] H_2S production from D-cysteine and polysulfides as H_2S-derived signaling molecules2013

    • Author(s)
      Kimura, H
    • Organizer
      The 13th International Congress on Amino Acids, Peptides and Proteins
    • Place of Presentation
      Galveston Island Convention Center, Galvestone, USA
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Open Plenary: Physiological function of hydrogen sulfide and beyond.2013

    • Author(s)
      Kimura H
    • Organizer
      The 2nd European Conference on the Biology of Hydrogen Sulfide
    • Place of Presentation
      Exeter, UK
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] H2S production from D-cysteine and polysulfides as H2S-derived signaling molecules.2013

    • Author(s)
      Kimura H
    • Organizer
      The 13th International Congress on Amino Acids, Peptides and Proteins
    • Place of Presentation
      Galvestone, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Another pathway to produce H2S in the brain2012

    • Author(s)
      Shibuya, N., Ishigami, M., Tanaka, M., Kimura, Y., Ogasawara, Y., Fukui, K., Kimura, H
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場, 福岡
    • Year and Date
      2012-12-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Hydrogen sulfide protects neurons from oxidative stress by increasing glutathione production and suppresses mitochondrial oxidative stress2012

    • Author(s)
      Kimura, Y., Goto, Y., Kimura, H
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of H_2S production by 3-mercaptopyruvate sulfurtransferase2012

    • Author(s)
      Kimura, H., Mikami, Y., Shibuya, N., Kimura, Y., Ogasawara, Y., Nagahara, N
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 結合型イオウの神経細胞における生理機能の解析2012

    • Author(s)
      小池 伸, 小笠原裕樹, 渋谷典広, 木村英雄, 石井一行
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Related Report
      2013 Final Research Report
  • [Presentation] CaMKIIおよびPKC による硫化水素生産酵素CBS のリン酸化について2012

    • Author(s)
      土屋幸弘, 久野竜弥, 山田 薫, 波多野直哉, 渋谷典広, 木村英雄, 渡邊泰男
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Related Report
      2013 Final Research Report
  • [Presentation] マウスにおける生理活性物質H2S の生産経路2012

    • Author(s)
      渋谷典広, 石上磨里, 田中真紀子, 木村由佳, 小笠原裕樹, 福井清, 木村英雄
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場, 福岡
    • Year and Date
      2012-12-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Another pathway to produce H2S in the brain2012

    • Author(s)
      Shibuya, N., Ishigami, M., Tanaka, M., Kimura, Y., Ogasawara, Y., Fukui, K., Kimura, H
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場, 名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] H2S is a Signaling Molecule and a Cytoprotectant2012

    • Author(s)
      Kimura, H
    • Organizer
      The Second International Conference on H2S Biology and Medicine
    • Place of Presentation
      Sheraton Atlanta Hotel, Atlanta, USA
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Hydrogen sulfide (H2S) protects retinal photoreceptor cells from light-induced degeneration2012

    • Author(s)
      Mikami, Y., Shibuya, N., Kimura, Y., Nagahara, N., Yamada, M., Kimura, H.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Hydrogen sulfide protects neurons from oxidative stress by increasing glutathione production and suppresses mitochondrial oxidative stress2012

    • Author(s)
      Kimura, Y., Goto, Y., Kimura, H
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] H_2S production by 3MST and its physi8ological role in the retina2012

    • Author(s)
      Kimura, H
    • Organizer
      The First European Conference on the Biology of H_2S
    • Place of Presentation
      Smolenice Castle, Blatislava, Slovakia
    • Year and Date
      2012-06-17
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] H2S signaling : from hypothesis to function in the nervous system2012

    • Author(s)
      Kimura, H
    • Organizer
      Experimental Biology 2012
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2012-04-24
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] H2S signaling:from hypothesis to function in the nervous system2012

    • Author(s)
      Hideo Kimura
    • Organizer
      Experimental Biology 2012
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] H2S production by 3MST and its physiological role in the retina2012

    • Author(s)
      Hideo Kimura
    • Organizer
      First European Conference on the Biology of Hydrogen Sulfide
    • Place of Presentation
      Smolenice Castle, Bratislava, Slovakia
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] H2S is a signaling molecule and a cytoprotectant2012

    • Author(s)
      HIdeo Kimura
    • Organizer
      Second International Conference on H2S Biology and Medicine
    • Place of Presentation
      Sheraton Atlanta Hotel, Atlanta, USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Another pathway to produce H2S in the brain2012

    • Author(s)
      Shibuya, N., Ishigami, M., Tanaka, M., Kimura, Y., Ogasawara, Y., Fukui, K., Kimura, H.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Hydrogen sulfide protects neurons from oxidative stress by increasing glutathione production and suppresses mitochondrial oxidative stress.2012

    • Author(s)
      Kimura, Y., Goto, Y., Kimura, H.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Hydrogen sulfide (H2S) protects retinal photoreceptor cells from light-induced degeneration.2012

    • Author(s)
      Mikami, Y., Shibuya, N., Kimura, Y., Nagahara, N., Yamada, M., Kimura, H.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] マウス脳における新規のH2S生産経路2011

    • Author(s)
      渋谷典広, 田中真紀子, 石上磨里, 木村由佳, 小笠原裕樹, 木村英雄
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会議場, 京都
    • Year and Date
      2011-09-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 3-メルカプトピルビン酸イオウ転位酵素の硫化水素生産補因子2011

    • Author(s)
      木村英雄, 三上義礼, 渋谷典広, 木村由佳, 永原則之, 小笠原裕樹
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 網膜における硫化水素の生合成と細胞保護作用2011

    • Author(s)
      三上義礼, 渋谷典広, 木村由佳, 永原則之, 山田雅弘, 木村英雄
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Neuroprotection by hydrogen sulfide; Suppression of oxidative stress in mitochondria by increasing glutathione levels2011

    • Author(s)
      Yuka Kimura, Yu-ichi Goto, Hideo Kimura
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 硫化水素は酸化的ストレスから神経細胞を保護する2011

    • Author(s)
      木村由佳, 後藤雄一, 木村英雄
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Year and Date
      2011-09-17
    • Related Report
      2013 Final Research Report
  • [Presentation] H2S生産酵素3MSTの補因子の探索2011

    • Author(s)
      木村英雄, 三上義礼, 渋谷典広, 木村由佳, 小笠原裕樹
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳における硫化水素生産酵素の探索2011

    • Author(s)
      渋谷典広, 石上磨里, 田中真紀子, 木村由佳, 小笠原裕樹, 木村英雄
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 網膜におけるH 2Sの生産制御とその細胞保護作用の解析2011

    • Author(s)
      三上義礼, 渋谷典広, 木村由佳, 永原則之, 山田雅弘, 木村英雄
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Hydrogen sulfide is a cytoprotectant from oxidative stress2011

    • Author(s)
      Kimura H
    • Organizer
      The 2nd Polish Congress of Biochemistry and Cell Biology (The 46th Meeting of the Polish Biochemical Society, The 11th Conference of the Polish Cell Biology Society)
    • Place of Presentation
      Jagiellonian University Convention Center, Krakow
    • Year and Date
      2011-09-08
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] The production and function of hydrogen sulfide. In Gasotransmitter and signal transduction2011

    • Author(s)
      Kimura H
    • Organizer
      The 2nd Polish Congress of Biochemistry and Cell Biology (The 46th Meeting of the Polish Biochemical Society, The 11th Conference of the Polish Cell Biology Society)
    • Place of Presentation
      Jagiellonian University Convention Center, Krakow
    • Year and Date
      2011-09-06
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] H2S production and its neuroprotective effect. In Sulfur amino acid2011

    • Author(s)
      Kimura H
    • Organizer
      12th International Congress on amino acids, peptides and proteins
    • Place of Presentation
      Beijing International Convention Center, Beijing
    • Year and Date
      2011-08-01
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 企画講演IV 毒ガス硫化水素の医療応用2011

    • Author(s)
      木村英雄
    • Organizer
      第26回日本老年精神医学会
    • Place of Presentation
      京王プラザホテル, 東京
    • Year and Date
      2011-06-17
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Hydrogen sulfide : its production and functions. In Emerging roles for gasotransmitters2011

    • Author(s)
      Kimura H
    • Organizer
      Experimental Biology 2011
    • Place of Presentation
      Washington Convention Center, Washington DC
    • Year and Date
      2011-04-12
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 硫化水素の機能と医療応用2011

    • Author(s)
      木村英雄
    • Organizer
      分子状水素医学シンポジウム
    • Place of Presentation
      名古屋大学医学部附属病院3階講堂, 名古屋
    • Year and Date
      2011-02-19
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 硫化水素 : 生合成, 放出, 生理機能

    • Author(s)
      木村英雄
    • Organizer
      第84回日本薬理学会, シンポジウム
    • Place of Presentation
      誌上開催
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳における硫化水素の生産酵素

    • Author(s)
      渋谷典広, 石上磨里, 田中真紀子, 木村由佳, 小笠原裕樹, 木村英雄
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      震災で中止
    • Related Report
      2013 Final Research Report
  • [Presentation] 硫化水素はグルタチオンの産生の増大と, ミトコンドリアにおける酸化ストレスの抑制により, 神経細胞を酸化的ストレスから保護する

    • Author(s)
      木村由佳, 後藤雄一, 木村英雄
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      震災で中止
    • Related Report
      2013 Final Research Report
  • [Presentation] H2Sの生産制御と細胞保護作用

    • Author(s)
      三上義礼, 渋谷典広, 木村由佳, 小笠原裕樹, 永原則之, 木村英雄
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      震災で中止
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of H2S production by cystathionine gamma-lyase by calcium.

    • Author(s)
      Kimura, H, Mikami, Y., Shibuya, N., Ogasawara, Y.
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells

    • Author(s)
      Shibuya, N., Koike, S., Tanaka, M., Ishigami-Yuasa, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nahahara, N., Kimura, H.
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] Signaling mechanism of hydrogen sulfide in astrocytes.

    • Author(s)
      Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I., Kimura, H.
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] Polysulfides are possible H2S-derived signaling molecules in rat brain.

    • Author(s)
      Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I., Kimura, H.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生理活性物質H2Sの新規生産経路

    • Author(s)
      渋谷 典広, 小池 伸, 湯浅(石上) 磨里, 田中 真紀子, 木村 由佳, 小笠原 裕樹, 福井 清, 永原 則之, 木村 英雄
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Polysulfides are potential H2S-derived signaling molecules that activate TRPA1 channels in rat brain.

    • Author(s)
      Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I., Kimura, H.
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] Hydrogen sulfide protects retina from light-induced degeneration

    • Author(s)
      Kimura, H., Mikami, Y., Shibuya, N., Kimura, Y., Nagahara, N., Yamada, M.
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells.

    • Author(s)
      Shibuya, N., Koike, S., Ishigami-Yuasa, M., Tanaka, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nagahara, N., Kimura, H.
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 結合型イオウの神経細胞における生理機能の解析

    • Author(s)
      小池 伸, 小笠原 裕樹, 渋谷 典広, 木村 英雄, 石井一行
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] Another pathway to produce H2S in the brain.

    • Author(s)
      Shibuya, N., Ishigami, M., Tanaka, M., Kimura, Y., Ogasawara, Y., Fukui, K., Kimura, H.
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場、福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Hydrogen sulfide protects neurons from oxidative stress by increasing glutathione production and suppresses mitochondrial oxidative stress.

    • Author(s)
      Kimura, Y., Goto, Y., Kimura, H.
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場、福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Regulation of H2S production by 3-mercaptopyruvate sulfurtransferase.

    • Author(s)
      Kimura, H., Mikami, Y., Shibuya, N., Kimura, Y., Ogasawara, Y., Nagahara, N.
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場、福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 結合型イオウの神経細胞における生理機能の解析

    • Author(s)
      小池 伸、小笠原裕樹、渋谷典広、木村英雄、石井一行
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場、福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] CaMKIIおよびPKCによる硫化水素生産酵素CBSのリン酸化について

    • Author(s)
      土屋幸弘、久野竜弥、山田 薫、波多野直哉、渋谷典広、木村英雄、渡邊泰男
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場、福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] マウスにおける生理活性物質H2Sの生産経路

    • Author(s)
      渋谷典広、石上磨里、田中真紀子、木村由佳、小笠原裕樹、福井清、木村英雄
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場、福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 硫化水素は、神経細胞における硫化水素の細胞保護作用;グルタチオンの産生の増大と、ミトコンドリアにおける酸化的ストレスの抑制

    • Author(s)
      木村由佳、後藤雄一、木村英雄
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場、福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 硫化水素(H2S)の生合成と光障害からの視神経保護

    • Author(s)
      木村英雄、三上義礼、渋谷典広、木村由佳、永原則之、山田雅弘
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場、福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 硫化水素選択的蛍光プローブの開発とその応用

    • Author(s)
      篠倉 潔、花岡健二郎、渋谷典広、木村英雄、長野哲雄
    • Organizer
      日本薬学会 第133年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Hydrogen sulfide: its production and functions.

    • Author(s)
      Kimura H.
    • Organizer
      Experimental Biology 2011(招待講演)
    • Place of Presentation
      Walter E. Washington Convention center, Washington DC, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] H2S production and its neuroprotective effect.

    • Author(s)
      Kimura H.
    • Organizer
      12th International Congress on amino acids, peptides and proteins(招待講演)
    • Place of Presentation
      Beijing International Convention Center, Beijing, China
    • Related Report
      2011 Research-status Report
  • [Presentation] The production and function of hydrogen sulfide.

    • Author(s)
      Kimura H.
    • Organizer
      The 2nd Polish Congress of Biochemistry and Cell Biology(招待講演)
    • Place of Presentation
      Krakow Convention Center, Krakow, Poland
    • Related Report
      2011 Research-status Report
  • [Presentation] Hydrogen sulfide is a cytoprotectant from oxidative stress.

    • Author(s)
      Kimura H.
    • Organizer
      The 2nd Polish Congress of Biochemistry and Cell Biology(招待講演)
    • Place of Presentation
      Krakow Convention Center, Krakow, Poland
    • Related Report
      2011 Research-status Report
  • [Presentation] 毒ガス硫化水素の医療応用

    • Author(s)
      木村英雄
    • Organizer
      第26回日本老年精神医学会(招待講演)
    • Place of Presentation
      京王プラザホテル、東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 硫化水素:生合成、放出、生理機能

    • Author(s)
      木村英雄
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      横浜、震災のため誌上開催
    • Related Report
      2011 Research-status Report
  • [Presentation] 硫化水素は酸化的ストレスから神経細胞を保護する

    • Author(s)
      木村由佳、後藤雄一、木村英雄
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] H2S生産酵素3MSTの補因子の探索

    • Author(s)
      木村英雄、三上義礼、渋谷典広、木村由佳、小笠原裕樹
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 脳における硫化水素生産酵素の探索

    • Author(s)
      渋谷典広、石上磨里、田中真紀子、木村由佳、小笠原裕樹、木村英雄
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 網膜におけるH2Sの生産制御とその細胞保護作用の解析

    • Author(s)
      三上義礼、渋谷典広、木村由佳、永原則之、山田雅弘、木村英雄
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] マウス脳における新規のH2S生産経路

    • Author(s)
      渋谷典広、田中真紀子、石上磨里、木村由佳、小笠原裕樹、木村英雄
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 網膜における硫化水素の生合成と細胞保護作用

    • Author(s)
      三上義礼、渋谷典広、木村由佳、永原則之、山田雅弘、木村英雄
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都、国立京都国際会館
    • Related Report
      2011 Research-status Report
  • [Presentation] Neuroprotection by hydrogen sulfide; Suppression of oxidative stress in mitochondria by increasing glutathione levels

    • Author(s)
      Yuka Kimura, Yu-ichi Goto, Hideo Kimura
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都、国立京都国際会館
    • Related Report
      2011 Research-status Report
  • [Presentation] 3-メルカプトピルビン酸イオウ転位酵素の硫化水素生産補因子

    • Author(s)
      木村英雄、三上義礼、渋谷典広、木村由佳、永原則之、小笠原裕樹
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都、国立京都国際会館
    • Related Report
      2011 Research-status Report
  • [Presentation] 脳における硫化水素の生産酵素

    • Author(s)
      渋谷典広、石上磨里、田中真紀子、木村由佳、小笠原裕樹、木村英雄
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      横浜、震災のため誌上開催
    • Related Report
      2011 Research-status Report
  • [Presentation] 硫化水素はグルタチオンの生産の増大と、ミトコンドリアにおける酸化ストレスの抑制により、神経細胞を酸化ストレスから保護する

    • Author(s)
      木村由佳、後藤雄一、木村英雄
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      横浜、震災のため誌上開催
    • Related Report
      2011 Research-status Report
  • [Presentation] H2Sの生産制御と細胞保護作用

    • Author(s)
      三上義礼、渋谷典広、木村由佳、小笠原裕樹、永原則之、木村英雄
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      横浜、震災のため誌上開催
    • Related Report
      2011 Research-status Report
  • [Book] Hydrogen sulfide-mediated cellular signaling and cytoprotection. In Hydrogen Sulfide and its Therapeutic Applications.2013

    • Author(s)
      Kimura, H(Ed by Hideo Kimura)
    • Publisher
      Springer Wien Heidelberg New York Dordrecht London
    • Related Report
      2013 Final Research Report
  • [Book] Hydrogen sulfide and its therapeutic applications2013

    • Author(s)
      Kimura H
    • Total Pages
      207
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Book] Physiological and pathophysiological functions of hydrogen sulfide. In Gasotransmitters: Physiology and Pathophysiology.2012

    • Author(s)
      Kimura, H(Ed. By Anton Herman, Guezel F. Sitdikova, and Thomas M. Weiger)
    • Publisher
      Springer Heidelberg New York Dordrecht London
    • Related Report
      2013 Final Research Report
  • [Book] Gasotransmitters: Physiology and Pathopysiology2012

    • Author(s)
      Hideo Kimura
    • Total Pages
      204
    • Publisher
      Springer
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.ncnp.go.jp/nin/guide/r_dna/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 独立行政法人国立精神・神経医療研究センター神経研究所神経薬理研究部

    • URL

      http://www.ncnp.go.jp/nin/guide/r_dna/index.html

    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] D-システインを有効成分として含有する硫化水素産生誘導剤2013

    • Inventor(s)
      木村英雄, 渋谷典広
    • Industrial Property Rights Holder
      発明者, 国立精神・神経医療研究センター, 大塚製薬工場
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-07-19
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] D-システインを有効成分として含有する硫化水素産生誘導剤2013

    • Inventor(s)
      木村英雄、渋谷典広
    • Industrial Property Rights Holder
      発明者、国立精神・神経医療研究センター、大塚製薬工場
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-07-19
    • Related Report
      2013 Annual Research Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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