Therapeutic strategies for diabetic complications by using Imatinib

• Project/Area Number: 23659098
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Sapporo Medical University
• Principal Investigator: FUJIMIYA Mineko 札幌医科大学, 医学部, 教授 (10199359)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 糖尿病合併症 / 肝臓 / 腎臓 / イマチ二ブ / 骨髄由来細胞 / グリーベック / イマチニブ / 糖尿病 / 臓器障害 / 細胞融合 / STZマウス / HFD糖尿病

Research Abstract

Results showed that imatinib inhibits the infiltration of abnormalbone marrow-derived cells into peripheral organs and blocked TNFα expression in thekidney and liver of diabetic animals. Therefore imatinib has a therapeutic potential fordiabetic complications.

Research Products

• [Journal Article] Bone Marrow Stem Cell Abnormality and Diabetic Complications (2012)
  • Author(s): Fujimiya M, Nagaishi K, Yamashita T, Ataka K.
  • Journal Title: Anat Rec Volume: (in press) Issue: 6 Pages: 917-21
  • DOI: 10.1002/ar.22445
  • NAID: 40019474228
  • Peer Reviewed
• [Journal Article] Fusion of bone marrow-derived cells with renal tubules contributes to renal dysfunction in diabetic nephropathy. (2012)
  • Author(s): Yamashita T
  • Journal Title: FASEB J Volume: 26 Issue: 4 Pages: 1559-1568
  • DOI: 10.1096/fj.11-183194
  • Peer Reviewed
• [Journal Article] 糖尿病合併症における骨髄細胞の意義 (2012)
  • Author(s): 藤宮峯子
  • Journal Title: 循環器内科 Volume: 72巻 Pages: 426-430
  • NAID: 40019474228
  • Peer Reviewed
• [Journal Article] Fusion of bone marrow-derived cells with renal tubules contributes to renal dysfunction in diabetic nephropathy. (2012)
  • Author(s): Yamashita T, Fujimiya M, et al.
  • Journal Title: FASEB J. Volume: 26 Pages: 1559-1568
  • Peer Reviewed
• [Journal Article] Transfer of Bone Marrow Progenitors Prevents Coronary Insufficiency and Systolic Dysfunction in the Mechanical Unloaded Heart in Mice. (2011)
  • Author(s): Koike M, Kojima H, Fujimiya M, et al.
  • Journal Title: J Surg Res. Volume: 171 Pages: 47-57
  • Peer Reviewed
• [Presentation] 骨髄間葉系幹細胞を用いた糖尿病性肝障害に対する新規治療法 (2013)
  • Author(s): 永石歓和、安宅弘司、石川浩三、藤宮峯子
  • Organizer: 日本再生医療会
  • Place of Presentation: 横浜
• [Presentation] 骨髄間葉系幹細胞を用いた糖尿病合併症の治療 (2013)
  • Author(s): 永石歓和、安宅弘司、石川浩三、藤宮峯子
  • Organizer: 日本解剖学会
  • Place of Presentation: 高松
• [Presentation] 糖尿病における骨髄幹細胞の異常 (2013)
  • Author(s): 永石歓和、安宅弘司、石川浩三、藤宮峯子
  • Organizer: 日本解剖学会
  • Place of Presentation: 高松
• [Presentation] 骨髄間葉系幹細胞を用いた糖尿病性肝障害に対する新規治療法 (2013)
  • Author(s): 永石歓和
  • Organizer: 日本再生医療学会
  • Place of Presentation: 横浜
• [Presentation] 糖尿病合併症の原因となる骨髄幹細胞異常 (2011)
  • Author(s): 藤宮峯子
  • Organizer: 第67回 日本顕微鏡学会(招待講演)
  • Place of Presentation: 福岡
• [Presentation] 糖尿病でおこる骨髄幹細胞異常 (2011)
  • Author(s): 藤宮峯子
  • Organizer: 第1回 細胞再生医療研究会(招待講演)
  • Place of Presentation: 神戸
• [Presentation] 骨髄由来ミクログリアと脳腸相関 (2011)
  • Author(s): 藤宮峯子
  • Organizer: 第13回 日本神経消化器病学会(招待講演)
  • Place of Presentation: 宇都宮
• [Patent(Industrial Property Rights)] Replacement of bone marrow niche cells for treatment of various diseases (2012)
  • Inventor(s): 藤宮峯子、安宅弘司、千葉弘規
  • Industrial Property Rights Holder: 札幌医科大学
  • Filing Date: 2012
  • Overseas