Searching for novel Dnase executing autophagic cell death.

• Project/Area Number: 23659102
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Juntendo University
• Principal Investigator: UCHIYAMA Yasuo 順天堂大学, 医学部, 教授 (10049091)
• Co-Investigator(Kenkyū-buntansha): KOIKE Masato 順天堂大学, 医学部, 准教授 (80347210) ; SASAKI Mitsuho 順天堂大学, 医学部, 助教 (20432536) ; SUNABORI Takehiko 順天堂大学, 医学部, 助教 (00407115) ; SUZUKI Suzuki 順天堂大学, 医学部, 助教 (40536629)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: LMPCR / 海馬 / CAD / 細胞死 / 低酸素脳虚血付加 / ノックアウトマウス / DNase II / プロセッシング / DNaseII / 低酸素脳虚血負荷

Research Abstract

We focused on DNase II as a candidate DNase executing autophagic cell death after hypoxic-ischemic (H-I) brain injury. To understand the molecular properties of DNase II, particularly the processing, we prepared a polyclonal antibody against mouse DNase II. Furthermore we succeeded in generating double knockout mice lacking both CAD (Caspase-activated DNase) and DNase II (CAD-/-DNase II mice). Using CAD-/-DNase II neonatal and adult mice, we examined H-I brain injury and found that DNA laddering was detectable in the ipsilateral hippocampus, indicating nuclear DNA in the damaged neurons was fragmented by a DNase other than CAD.

Research Products

• [Journal Article] Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons (2013)
  • Author(s): Koike, M.*, Tanida, I.*, Nanao, T., Tada, N., Iwata, J., Ueno, T., Kominami, E., Uchiyama, Y
  • Journal Title: PLoS One Volume: 8(5)
• [Journal Article] ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons (2013)
  • Author(s): Matsui, H.*, Sato, F.*, Sato, S., Koike, M., Taruno, Y., Saiki, S., Funayama, M., Ito, H., Taniguchi, Y., Uemura, N., Toyoda, A., Sakaki, Y., Takeda, S., Uchiyama, Y., Hattori, N., Takahashi, R.
  • Journal Title: FEBS letters Volume: 587(9) Pages: 1316-25
• [Journal Article] Biogenesis and proteolytic processing of lysosomal DNase II (2013)
  • Author(s): Ohkouchi, S., Shibata, M., Sasaki, M., Koike, M., Saftig, P., Peters, C., Nagata, S., Uchiyama, Y
  • Journal Title: PLoS One Volume: 8(3)
• [Journal Article] Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous systems (2013)
  • Author(s): Koike, M., Shibata, M., Ezaki, J., Peters, C., Saftig, P., Kominami, E., Uchiyama, Y.
  • Journal Title: Eur. J. Neurosci. Volume: 37(5) Pages: 816-20
• [Journal Article] Lysosomal storage and advanced senescence in the brain of LAMP-2-deficient Danon disease (2013)
  • Author(s): Furuta, A., Wakabayashi, K., Haratake, J., Kikuchi, H., Kabuta, T., Mori, F., Tokonami, F., Katsumi, Y., Tanioka, F., Uchiyama, Y., Nishino, I., Wada, K..
  • Journal Title: Acta Neuropathol Volume: 125(3) Pages: 459-461
• [Journal Article] Resveratrol affects undifferentiated and differentiated PC12 cells differently, particularly with respect to possible differences in mitochondrial and autophagic functions (2013)
  • Author(s): Hayakawa, N., Shiozaki, M., Shibata, M., Koike, M., Uchiyama, Y., Gotow, T.
  • Journal Title: Eur. J. Cell Biol Volume: 92(1) Pages: 30-43
• [Journal Article] Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons. (2013)
  • Author(s): Koike M
  • Journal Title: ProsOne, Volume: in press
  • Peer Reviewed
• [Journal Article] Biogenesis and Proteolytic Processing of Lysosomal DNase II. (2013)
  • Author(s): Ohkouchi, S., Shibata, M., Sasaki, M., Koike, M., Safig, P., Peters, C., Nagata, S., and Uchiyama, Y.
  • Journal Title: PloS One Volume: 8 Issue: 3 Pages: e59148-e59148
  • DOI: 10.1371/journal.pone.0059148
  • Peer Reviewed
• [Journal Article] Lysosomal storage and advanced senescence in the brain of LAMP-2-deficient Danon disease (2013)
  • Author(s): Furuta A, Wakabayashi K, Haratake J, Kikuchi H, Kabuta T, Mori F, Tokonami F, Katsumi Y, Tanioka F, Uchiyama Y, Nishino I, Wada K
  • Journal Title: Acta Neuropathol Volume: 125 Issue: 3 Pages: 459-461
  • DOI: 10.1007/s00401-012-1075-4
  • Peer Reviewed
• [Journal Article] c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. (2013)
  • Author(s): Piao X
  • Journal Title: Sci Signal Volume: ra93 Issue: 255
  • DOI: 10.1126/scisignal.2003558
  • Peer Reviewed
• [Journal Article] Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous systems. (2013)
  • Author(s): Koike M
  • Journal Title: Eur J Neurosci Volume: 37 Pages: 816-830
  • Peer Reviewed
• [Journal Article] Resveratrol affects undifferentiated and differentiated PC12 cells differently, particularly with respect to possible differences in mitochondrial and autophagic fuctions (2013)
  • Author(s): Hyakawa N., Shiozaki M., Shibata M., Koike M., Uchiyama Y., Matsuura N., Gotow T.
  • Journal Title: Eur. J. Cell Biol Volume: 92 Issue: 1 Pages: 30-43
  • DOI: 10.1016/j.ejcb.2012.10.002
  • Peer Reviewed
• [Journal Article] c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis (2012)
  • Author(s): Piao, X., Komazawa-Sakon, S., Nishida, T., Koike, M., Piao JH., Ehlken, H., Kurihara, H., Hara, M., van Rooijen, N., Schutz, G., Ohmuraya, M., Uchiyama, Y., Yagita, H., Okumura, K., He YW., Nakano, H.
  • Journal Title: Sci. Signal Volume: 5(255)
• [Journal Article] Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. (2012)
  • Author(s): Tashiro Y.*, Urushitani, M.*, Inoue, H., Koike, M., Uchiyama, Y., Komatsu, M., Tanaka, K., Yamazaki, M., Abe, M., Misawa, H., Sakimura, K., Ito, H., Takahashi, R
  • Journal Title: J. Biol. Chem Volume: 109(43) Pages: 42984-94
• [Journal Article] Mitochondrial dysfunction with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain (2012)
  • Author(s): Imaizumi, Y., Okada, Y., Akamatsu, W., Koike, M., Kuzumaki, N., Hayakawa, H., Nihira, T., Kobayashi, T., Ohyama, M., Sato, S., Takanashi, M., Funayama, M., Hirayama, A., Soga, T., Hishiki, T., Suematsu, M., Yagi, T., Ito, D., Kosakai, A., Hayashi, K., Shouji, M., Nakanishi, A., Suzuki, N., Mizuno, Y., Mizushima, N., Amagai, M., Uchiyama, Y., Mochizuki, H., Hattori, N., Okano, H.
  • Journal Title: Molecular Brain Volume: 5(1) Pages: 35-35
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy. (2012)
  • Author(s): Klionsky, D.J. and 1428 authors
  • Journal Title: Autophagy Volume: 8(4) Pages: 445-544
• [Journal Article] The development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6 (2012)
  • Author(s): Unno, T., Wakamori, M., Koike, M., Uchiyama, Y., Ishikawa, K., Kubota, H., Yoshida, T., Sasakawa, H., Peters, C., Mizusawa, H., Watase, K
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 109(43) Pages: 17693-8
• [Journal Article] Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5 (2012)
  • Author(s): Sekine, S., Kanamaru, Y., Koike, M., Nishihara, A., Okada, M., Kinoshita, H., Kamiyama, M., Maruyama, J., Uchiyama, Y., Ishihara, N., Takeda, K., Ichijo, H.
  • Journal Title: J. Biol. Chem Volume: 287(41) Pages: 34635-45
• [Journal Article] 神経性セロイドリポフスチン蓄積症における"異常なリソソーム"のオートファジーによる処理 (2012)
  • Author(s): 小池正人、内山安男
  • Journal Title: 生体の科学 Volume: 63(5) Pages: 404-5
• [Journal Article] Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis (2012)
  • Author(s): Y. Tashiro
  • Journal Title: Journal of Biological Chemistry Volume: 287 Issue: 51 Pages: 42984-42994
  • DOI: 10.1074/jbc.m112.417600
  • Peer Reviewed
• [Journal Article] Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6. (2012)
  • Author(s): Unno T
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Pages: 17693-17698
  • Peer Reviewed
• [Journal Article] Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5. (2012)
  • Author(s): Sekine S
  • Journal Title: J Biol Chem Volume: 287 Pages: 34635-34645
  • Peer Reviewed
• [Journal Article] Mitochondrial dysfunction associated with increased oxidative stress and -synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. (2012)
  • Author(s): Imaizumi Y
  • Journal Title: Mol Brain Volume: 5 Issue: 1 Pages: 35-35
  • DOI: 10.1186/1756-6606-5-35
  • Peer Reviewed
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy. (2012)
  • Author(s): Klionsky D
  • Journal Title: Atuophagy Volume: 8:4 Pages: 1-100
  • Peer Reviewed
• [Journal Article] Grafted human induced pluripotent stem-cell-derived neurospheres promotes motor functional recovery after spinal cord injury in mice. (2011)
  • Author(s): Nori, S., Okada, Y., Yasuda, A., Tsuji, O., Takahashi, Y., Kobayashi, Y., Fujiyoshi, K., Koike, M., Uchiyama, Y., Ikeda, E., Toyama, Y., Yamanaka, S., Nakamura, M., Okano, H
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108(40) Pages: 16825-30
• [Journal Article] Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes (2011)
  • Author(s): Uchida, Y., Hasegawa, J., Chinnapen, D., Inoue, T., Okazaki, S., Kato, R., Wakatsuki, S., Misaki, R., Koike, M., Uchiyama, Y., Iemura, S., Natsume, T., Kuwahara, R., Nakagawa, T., Nishikawa, K., Mukai, K., Miyoshi, E., Taniguchi, N., Sheff, D., Lencer, W.I., Taguchi, T., Arai H
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108(38) Pages: 15846-51
• [Journal Article] Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1 (2011)
  • Author(s): Koyanagi, M., Asahara, S., Matsuda, T., Hashimoto, N., Shigeyama, Y., Shibutani, Y., Kanno, A., Fuchita, M., Mikami, T., Hosooka, T., Inoue, H., Matsumoto, M., Koike, M., Uchiyama, Y., Noda, T., Seino, S., Kasuga, M., Kido, Y.
  • Journal Title: PLoS One Volume: 6(8)
• [Journal Article] Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice.Histochem. (2011)
  • Author(s): Shiozaki, M., Hayakawa, N., Shibata, M., Koike, M., Uchiyama, Y., Gotow, T.
  • Journal Title: Cell Biol Volume: 136(4) Pages: 475-89
• [Journal Article] Kuwahara, Y., Oikawa, T., Ochiai, Y., Roudkenar, M.H., Fukumoto, M., Shimura, T., Ohtake, Y., Ohkubo, Y., Mori, S., Uchiyama, Y., Fukumoto, M. (2011)
  • Author(s): Kuwahara, Y., Oikawa, T., Ochiai, Y., Roudkenar, M.H., Fukumoto, M., Shimura, T., Ohtake, Y., Ohkubo, Y., Mori, S., Uchiyama, Y., Fukumoto, M.
  • Journal Title: Cell Death Dis. Volume: 2(6)
• [Journal Article] リソソームプロテアーゼの多様性とその病態生理学的役割 (2011)
  • Author(s): 内山安男、小池正人
  • Journal Title: 実験医学増刊号 Volume: 29(12) Pages: 1903-1908
• [Journal Article] 虚血性細胞死とオートファジー (2011)
  • Author(s): 内山安男
  • Journal Title: 神経内科 Volume: 75(2) Pages: 169-175
• [Journal Article] Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease. (2011)
  • Author(s): Oguro M, Koike M, Ueno T, Asaoka D, Mori H, Nagahara A, Uchiyama Y, Watanabe S
  • Journal Title: J Gastroenterol. Volume: 46 Pages: 629-638
  • NAID: 10029029126
  • Peer Reviewed
• [Journal Article] Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1. (2011)
  • Author(s): Koyanagi M, Asahara A, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, Hosooka T, Inoue H, Matsumoto H, Koike M, Uchiyama Y, NodaT, Seino S, Kasuga M, Kido Y
  • Journal Title: PLosOne Volume: 6
  • Peer Reviewed
• [Journal Article] Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice. (2011)
  • Author(s): Shiozaki M, Hayakawa N, Shibata M, Koike M, Uchiyama Y, Gotow T
  • Journal Title: Histochem Cell Biol Volume: 136 Pages: 475-489
  • Peer Reviewed
• [Journal Article] Intracellular Phosphatidylserine Regulates Membrane Traffic Through Endosomes. (2011)
  • Author(s): Uchida Y et al.
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Pages: 15846-15851
  • Peer Reviewed
• [Journal Article] Grafted human induced pluripotent stem cell-derived neurospheres promotes motor functional recovery after spinal cord injury in mice. (2011)
  • Author(s): Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Yamanaka S, Nakamura M, Okano H
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108 Pages: 16825-16830
  • Peer Reviewed
• [Journal Article] Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy (2011)
  • Author(s): Kuwahara Y, Oikawa T, Ochiai Y, Roudkenar, M Fukumoto, T Shimura, Y Ohtake M H, Ohkubo Y, Mori S, Uchiyama Y, Fukumoto M
  • Journal Title: Cell Death Dis (2011) Volume: 2 Issue: 6 Pages: e177-e177
  • DOI: 10.1038/cddis.2011.56
  • Peer Reviewed
• [Journal Article] 脂肪的とオートファジー (2011)
  • Author(s): 内山安男
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 30 Pages: 338-343
• [Journal Article] リソソームプロテアーゼの多様性とその病態生理学的役割 (2011)
  • Author(s): 小池正人、内山安男
  • Journal Title: 実験医学増感号 Volume: 29 Pages: 1903-1908
• [Journal Article] RNAi法を利用した抗体の評価 (2011)
  • Author(s): 柴田昌宏、内山安男
  • Journal Title: 生体の科学 Volume: 63 Pages: 98-103
• [Journal Article] 脂肪滴とオートファジー (2001)
  • Author(s): 内山安男
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 33(4) Pages: 338-343
• [Presentation] 極性のあるニューロンへのリソソームオートファゴソームの局在について (2013)
  • Author(s): 内山安男
  • Organizer: 日本薬学会１３３年会
  • Place of Presentation: パシフィコ横浜
  • Invited
• [Presentation] 軸索終末部におけるAtg9Aを含む小胞の膜成分の精製および解析 (2013)
  • Author(s): 山口隼司
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] 初代培養神経細胞の成熟過程におけるリソソームの局在動態について (2013)
  • Author(s): 七尾友久
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] オートファジーモニタリングトランスジェニックマウスを用いた軸索終末部におけるオートファジーの機能解析 (2013)
  • Author(s): 佐々木光穂
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] オートファジー／リソソームプロテアーゼの腎虚血再灌流尿細管傷害における役割について (2013)
  • Author(s): 鈴木ちぐれ
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] SCA1モデルマウスにおけるプルキンエ細胞の初期変化について (2013)
  • Author(s): 古田晶子
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] Characteristic differences between Purkinje cells specifically deficient in cathepsin D and Atg7 (2013)
  • Author(s): 小池正人
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] Toll様受容体を介したオートファジー誘導機構について (2013)
  • Author(s): 砂堀毅彦
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] スリット1,2ダブルノックアウトマウスにおけるGnRHニューロンの移動と軸索投射 (2013)
  • Author(s): 村上志津子
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] 発生に伴う脳の内外の周皮細胞の変化 (2013)
  • Author(s): 宮川桃子
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] Hyaluronan tetrasaccharide rescues hippocampal pyramidal neuron death after hypoxic-ischemic injury. (2012)
  • Author(s): Yasuo Uchiyama
  • Organizer: 第１４回国際組織細胞化学会（ICHC２０１２）
  • Place of Presentation: 国立京都国際会館
  • Invited
• [Presentation] Characteristic differences between Purkinje cells specifically deficient in cathepsin D and Atg7 (2012)
  • Author(s): Yasuo Uchiyama
  • Organizer: 6th International Symposium on Autophagy
  • Place of Presentation: 沖縄 万国津梁館
  • Invited
• [Presentation] Cell death and autophagy (2012)
  • Author(s): Uchiyama Y
  • Organizer: The XXII International Symposium on Morphological Sciences
  • Place of Presentation: Sao Paulo in Brasil
• [Presentation] カテプシンBDダブルノックアウトマウスの中枢神経系の形態学的解析 (2012)
  • Author(s): 小池正人、山口隼司、内山安男
  • Organizer: 第17回グリアクラブ
  • Place of Presentation: ヒルトンニセコビリッジ
• [Presentation] 初代培養神経細胞の成熟過程に見られるリソソーム／オートファジー関連タンパク質の動態 (2012)
  • Author(s): 七尾友久、内山安男
  • Organizer: 第17回グリアクラブ
  • Place of Presentation: ヒルトンニセコビリッジ
• [Presentation] Autophagy in the neural network and its impairment (2012)
  • Author(s): Yasuo Uchiyama
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
• [Presentation] 発生初期過程の脳における PSA-NCAM 陽性周皮細胞の動態 (2012)
  • Author(s): 宮川桃子、石龍徳、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
• [Presentation] 鼻プラコード由来ソマトスタチン mRNA 陽性細胞の前脳進入と定着 (2012)
  • Author(s): 村上志津子、浜崎浩子、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
• [Presentation] 正常および老齢マウス脳におけるリソゾームカテプシン C の分布 (2012)
  • Author(s): 小池正人、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
• [Presentation] ほ乳類 Atg9AmRNA ノックダウンHeLa 細胞について/A study on Atg9AmRNA-knockdown HeLa cells (2012)
  • Author(s): 多村博澄、佐々木光穂、小池正人、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
• [Presentation] リソソーム膜タンパク質 LAMP-2 の中枢神経系における役割 (2012)
  • Author(s): 古田晶子、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
• [Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse after hypoxic-ischemic injury (2012)
  • Author(s): Sunabori Takehiko, Masato Koike, Yasuo Uchiyama
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
• [Presentation] The autophagy/lysosomal system is essential for the maintenance of the axon and its terminal (2011)
  • Author(s): Uchiyama Y
  • Organizer: The synapse from physiology to pathology
  • Place of Presentation: Stresa in Italy
• [Presentation] Acceleration of autophagy results in neurodegeneration (2011)
  • Author(s): Uchiyama Y
  • Organizer: 第10回日中合同組織細胞化学セミナー
  • Place of Presentation: 北京
• [Presentation] カテプシンD欠損に伴う神経性ロイドリポフスチン蓄積症の病態形成にオートファジーが果たす役割について (2011)
  • Author(s): 小池正人、内山安男
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 虚血生侵襲に対するヒアルロン酸４糖の神経細胞保護効果の検討 (2011)
  • Author(s): 砂堀毅彦、小池正人、内山安男
  • Organizer: 第３４回日本神経科学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Possible roles of LC3, ubiquitin, and P62 and/or Nbr1 in the accumulation of lysosomes in neurons deficient in Cathepsin D (2011)
  • Author(s): Masato Koike, Yasuo Uchiyama
  • Organizer: 41st Annual Meeting Society for Neuroscience
  • Place of Presentation: ワシントン・コンベンション・センター
• [Presentation] New neurons use Slit 1 to maintain astrocytic tunnels for their rapid migration in the adult brain (2011)
  • Author(s): Naoko Kanekoら
  • Organizer: 41st Annual Meeting Society for Neuroscience
  • Place of Presentation: ワシントン・コンベンション・センター
• [Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse brains after hypoxic-ischemic injury (2011)
  • Author(s): Sunabori Takehiko, Masato Koike, Yasuo Uchiyama
  • Organizer: 41st Annual Meeting Society for Neuroscience
  • Place of Presentation: ワシントン・コンベンション・センター
• [Presentation] Generation of mAtg9A transgenic mice. (2011)
  • Author(s): Sasaki Mitsuho, Yasuo Uchiyama
  • Organizer: 41st Annual Meeting Society for Neuroscience
  • Place of Presentation: ワシントン・コンベンションセンター
• [Presentation] mAtg9A-AcGFP および mDFCP1-mCherry トランスジェェニックマウスの作製 (2011)
  • Author(s): 佐々木光穂、多村博澄、多田昇弘、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
• [Presentation] 腎虚血尿細管傷害におけるオートファジー・リソソーム系の関わりについて (2011)
  • Author(s): 鈴木ちぐれ、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
• [Book] Autophagy regulates lipid droplet formation and adipogenesis. In: Lipid metabolism. Ed by Rodrigo Valenzuela Baez (2013)
  • Author(s): Uchiyama Y, Kominami E
  • Publisher: InTech
• [Book] Autophagy regulates lipid droplet formation and adipogenesis. In: Lipid metabolism. Ed by Rodrigo Valenzuela Baez. (2013)
  • Author(s): Uchiyama Y
  • Publisher: InTech
• [Book] Genetic mouse models for elucidation of autophagy-lysosomal systems in neurons under physiologic and pathologic conditions. In Ed. Zhenyu yue, Charleen T Chu: Autophagy of the nervous system -Cellular self-digestion in neurons and neurological diseases (2012)
  • Author(s): Komatsu M, Koike M, Ichimura Y, Uchiyama Y
  • Publisher: World Scientific
• [Book] 「リソソーム内の分解機構」オートファジー 生命をささえる細胞の自己分解システム (2012)
  • Author(s): 小池正人、内山安男
  • Publisher: 化学同人
• [Book] Genetic mouse models for elucidation of autophagy-lysosomal systems in neurons under physiologic and pathologic conditions. In Ed. Zhenyu yue, Charleen T Chu: Autophagy of the nervous system – Cellular self-digestion in neurons and neurological diseases. (2012)
  • Author(s): Komatsu M
  • Publisher: World Scientific
• [Book] Autophagy of the nervous system (Ed by Zhenyu Yue and Charleen Chu) World Scientifc (2012)
  • Author(s): Komatsu M, Koike M, Ichimura Y, Uchiyama Y
  • Total Pages: 464
  • Publisher: Genetic Mouse Models for Elucidation of Autophagy-Lysosomal Systems in Neurons Under Physiologic and Pathologic Condition
• [Remarks]
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/shinkei_kozo/index.html