Qualitative improvement of aged eggs and development of technologies supporting ART at later ages
| Project/Area Number |
23659107
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KURIHARA Hiroki 東京大学, 大学院・医学系研究科, 教授 (20221947)
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| Co-Investigator(Renkei-kenkyūsha) |
KURIHARA Yukiko 東京大学, 大学院・医学系研究科, 講師 (80345040)
UCHIJIMA Yasunobu 東京大学, 大学院・医学系研究科, 助手 (90272426)
KAWAMURA Yumiko 東京大学, 大学院・医学系研究科, 特任研究員 (70599779)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 生殖医学 / 老化 / 卵子 / 体外受精 / ミトコンドリア / サーチュイン遺伝子 / 初期発生 |
|---|
| Research Abstract |
Changes in women’s life styles have lead to the tendency of late childbearing, requiring ART at later ages. However, oxidative stress and decreased mitochondrial function are supposed to cause the deterioration of eggs with increasing age. In this study, we found that mitochondrial NAD+-dependent deacetylase Sirt3 may be involved in mechanisms underlying the deterioration and introduction of Sirt3 may improve the post-fertilization development. Furthermore, we established transgenic mice conditionally expressing Sirt3 in specific cell types including oocytes and eggs, whose phenotype is being analyzed.
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Report
(3 results)
Research Products
(83 results)
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[Journal Article] Resistin-Like Molecule β Is Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development.2013
Author(s)
Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.
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Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 33
Issue: 8
Pages: 1986-1993
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development2012
Author(s)
Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32
Issue: 2
Pages: 291-298
DOI
Related Report
Peer Reviewed
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[Journal Article] Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by expanded polyglutamine2012
Author(s)
Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G
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Journal Title
Nat Med
Volume: 18
Issue: 10
Pages: 1531-1538
DOI
Related Report
Peer Reviewed
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[Journal Article] Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model2012
Author(s)
Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuchi T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T
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Journal Title
J Biol Chem
Volume: 287
Issue: 53
Pages: 44526-44535
DOI
Related Report
Peer Reviewed
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