Qualitative improvement of aged eggs and development of technologies supporting ART at later ages

• Project/Area Number: 23659107
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: The University of Tokyo
• Principal Investigator: KURIHARA Hiroki 東京大学, 大学院・医学系研究科, 教授 (20221947)
• Co-Investigator(Renkei-kenkyūsha): KURIHARA Yukiko 東京大学, 大学院・医学系研究科, 講師 (80345040) ; UCHIJIMA Yasunobu 東京大学, 大学院・医学系研究科, 助手 (90272426) ; KAWAMURA Yumiko 東京大学, 大学院・医学系研究科, 特任研究員 (70599779)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 生殖医学 / 老化 / 卵子 / 体外受精 / ミトコンドリア / サーチュイン遺伝子 / 初期発生

Research Abstract

Changes in women’s life styles have lead to the tendency of late childbearing, requiring ART at later ages. However, oxidative stress and decreased mitochondrial function are supposed to cause the deterioration of eggs with increasing age. In this study, we found that mitochondrial NAD+-dependent deacetylase Sirt3 may be involved in mechanisms underlying the deterioration and introduction of Sirt3 may improve the post-fertilization development. Furthermore, we established transgenic mice conditionally expressing Sirt3 in specific cell types including oocytes and eggs, whose phenotype is being analyzed.

Research Products

• [Journal Article] Resistin-Like Molecule β Is Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development. (2013)
  • Author(s): Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 33 Issue: 8 Pages: 1986-1993
  • DOI: 10.1161/atvbaha.113.301546
  • Peer Reviewed / Open Access
• [Journal Article] Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development (2013)
  • Author(s): Akifumi Kushiyama
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: -
  • Peer Reviewed
• [Journal Article] A soluble form of LMIR5/CD300b amplifies lipopolysaccharide-induced lethal inflammation in sepsis. (2012)
  • Author(s): Yoshinori Yamanishi
  • Journal Title: Journal of Immunology Volume: 189 Issue: 4 Pages: 1773-1779
  • DOI: 10.4049/jimmunol.1201139
  • Peer Reviewed
• [Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development (2012)
  • Author(s): Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 32 Issue: 2 Pages: 291-298
  • DOI: 10.1161/atvbaha.111.234559
  • Peer Reviewed
• [Journal Article] Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by expanded polyglutamine (2012)
  • Author(s): Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G
  • Journal Title: Nat Med Volume: 18 Issue: 10 Pages: 1531-1538
  • DOI: 10.1038/nm.2932
  • Peer Reviewed
• [Journal Article] Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model (2012)
  • Author(s): Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuchi T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T
  • Journal Title: J Biol Chem Volume: 287 Issue: 53 Pages: 44526-44535
  • DOI: 10.1074/jbc.m112.397133
  • Peer Reviewed
• [Journal Article] Preotic neural crest cells contribute to coronary smooth muscle involving endothelin signalling. (2012)
  • Author(s): Yuichiro Arima
  • Journal Title: Nature Communications Volume: 3 Issue: 1 Pages: 1267-1267
  • DOI: 10.1038/ncomms2258
  • Peer Reviewed
• [Journal Article] Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney (2011)
  • Author(s): Kitazawa T, Sato T, Nishiyama K, Asai R, Arima Y, Uchijima Y, Kurihara Y, Kurihara H.
  • Journal Title: Gene Expr. Patterns Volume: 11 Issue: 7 Pages: 371-377
  • DOI: 10.1016/j.gep.2011.04.001
  • Peer Reviewed
• [Journal Article] Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement (2011)
  • Author(s): Arima S, Nishiyama K, Ko T, Arima Y, Hakozaki Y, Sugihara K, Koseki H, Uchijima Y, Kurihara Y, Kurihara H.
  • Journal Title: Development Volume: 138 Issue: 21 Pages: 4763-4776
  • DOI: 10.1242/dev.068023
  • Peer Reviewed
• [Journal Article] Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial movement (2011)
  • Author(s): Satoshi Arima, Koichi Nishiyama
  • Journal Title: Development Volume: 138 Pages: 4763-4776
  • Peer Reviewed
• [Presentation] MicroRNA 199/214 cluster is required for normal growth and skeletal development in mice (2012)
  • Author(s): Yumiko Kawamura
  • Organizer: Cell Synposia,Functional RNAs
  • Place of Presentation: Sitges(Spain)
  • Year and Date: 2012-12-04
• [Presentation] Involvement of non-coding RNA Evf2 in the endothelin signaling in branchial arch development (2012)
  • Author(s): Yukiko Kurihara
  • Organizer: Cell Synposia, Functional RNAs
  • Place of Presentation: Sitges(Spain)
  • Year and Date: 2012-12-03
• [Presentation] The novel contribution of preotic neural crest cells in the coronary artery development (2012)
  • Author(s): Yuichiro Arima
  • Organizer: AHA scientific session2012
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2012-11-15
• [Presentation] A defensive role of Sirt3 against oxidative stress and aging in preimplantation embryos (2012)
  • Author(s): Yumiko Kawamura
  • Organizer: the 25th Annual Mouse Molecular Genetics Conference
  • Place of Presentation: Pacific Grove, California (USA)
  • Year and Date: 2012-10-03
• [Presentation] Cell-based mechanism behind angiogenic morphogenesis: analysis using both experimental and computational approaches (2012)
  • Author(s): Koichi Nishiyama
  • Organizer: 7th International Kloster Seeon Meeting 'Angiogenesis': Molecular Mechanisms and Functional Interactions
  • Place of Presentation: KLOSTER SEEON(Germany)
  • Year and Date: 2012-09-15
• [Presentation] Analysis of cell-based mechanisms involved in angiogenic morphogenesis by biological and computational approaches (2012)
  • Author(s): Koichi Nishiyama
  • Organizer: 17th International Vascular
  • Place of Presentation: Rhein-Main-Hallen Wiesbaden(Germany)
  • Year and Date: 2012-06-09
• [Presentation] Mouse-chick chimeric transplantation reveals the regional contribution of the cell population arising from the inflow tract to cardiac chamber formation (2012)
  • Author(s): Rieko Asai
  • Organizer: Weinstein Cardiovascular Development Conference 2012
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2012-05-03
• [Presentation] The neural crest contributes to coronary artery smooth muscle formation through endothelin signaling (2012)
  • Author(s): Yuichiro Arima
  • Organizer: Weinstein Cardiovascular Development Conference 2012
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2012-05-03
• [Presentation] Involvement of non-coding RNA: Evf2 in the Endothelin signaling in branchial arch development (2012)
  • Author(s): Yukiko Kurihara
  • Organizer: Keystone Symposia Canference Non-Coding RNAs
  • Place of Presentation: Snowbird Cliff lodge (USA)
  • Year and Date: 2012-04-02
• [Presentation] Protective role of Sirt3 against p53-dependent developmental arrest induced by oxidative stress in preimplantation embryos (2012)
  • Author(s): Yumiko Kawamura
  • Organizer: Keystone Symposia "Sirtuins in metabolism, aging and disease
  • Place of Presentation: Granlibakken Resort, TahoeCity, California (USA)
  • Year and Date: 2012-02-13
• [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis (2012)
  • Author(s): Taro Kitazawa
  • Organizer: Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
  • Place of Presentation: Four Points by Sheraton Los Angeles (USA)
• [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis (2012)
  • Author(s): Taro Kitazawa
  • Organizer: Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
  • Place of Presentation: フォーポイント・バイ・シェラトン･ロサンゼルス（米国）
• [Presentation] Ex vivo血管新生における血管内皮細胞の集団的運動 (2012)
  • Author(s): Koichi Nishiyama
  • Organizer: 第117回日本解剖学会総会・全国学術集会(招待講演)
  • Place of Presentation: 山梨大学（山梨県 甲府市）
• [Presentation] Novel roles of the neural crest in coronary artery formation through the Endothelin-1/ Endothelin A receptor signaling. (2012)
  • Author(s): Yuichiro Arima
  • Organizer: 第76回 日本循環器学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡県 福岡市)
• [Presentation] Involvement of non-coding RNA: Evf2 in the Endothelin signaling in branchial arch development (2012)
  • Author(s): Yukiko Kurihara
  • Organizer: Keystone Symposia Canference Non-Coding RNAs
  • Place of Presentation: スノウバード・クリフロッジ（米国）
• [Presentation] Collectiveendothelial cell movement in angiogenic morphogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando Convention Center(USA)
  • Year and Date: 2011-11-15
• [Presentation] Coronary artery anomalies in Endothelin-1 and Endothelin A receptor knockout mice (2011)
  • Author(s): Yuichiro Arima
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando Convention Center(USA)
  • Year and Date: 2011-11-15
• [Presentation] The first heart field subdomain defined by endothelin receptor type-A expression contributes to conduction system development (2011)
  • Author(s): Rieko Asai
  • Organizer: ESC Working Group on Developmental Anatomy and Pathology
  • Place of Presentation: Liblice Casstle(Czech)
  • Year and Date: 2011-09-24
• [Presentation] Endothelin receptor type-Aexpression defines a distinct subdomain within the heart field and contributes tochamber myocardium (2011)
  • Author(s): Rieko Asai
  • Organizer: WeinsteinCardiovascular Development Conference 2011
  • Place of Presentation: Hilton Cincinnati(USA)
  • Year and Date: 2011-05-06
• [Presentation] Endothelin-1/Endothelin type-A receptor signaling regulates pharyngeal arch artery development through Dlx5/6-independent pathway (2011)
  • Author(s): Ki-Sung Kim
  • Organizer: 2011 Pediatric Academic Societies and Asian Society for Pediatric Research joint meeting
  • Place of Presentation: Denver Convention Center(USA)
  • Year and Date: 2011-05-01
• [Presentation] Endothelin-1/Endothelin type-A receptor signaling regulates pharyngeal arch artery development through Dlx5/6-independent pathway. (2011)
  • Author(s): Ki-Sung Kim
  • Organizer: 2011 Pediatric Academic Societies and Asian Society for Pediatric Research joint meeting
  • Place of Presentation: Denver Convention Center, （Denver, USA）
• [Presentation] Endothelin receptor type-A expression defines a distinct subdomain within the heart field and contributes to chamber myocardium (2011)
  • Author(s): Rieko Asai
  • Organizer: Weinstein Cardiovascular Development Conference 2011
  • Place of Presentation: ヒルトン シンシナティ ネーデルランド プラザ（米国）
• [Presentation] Endothelin receptor type-A expression defines a distinct subpopulation within the heart field and contributes to chamber myocardium formation (2011)
  • Author(s): Rieko Asai
  • Organizer: 第44回日本発生生物学会年会
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県 宜野湾市）
• [Presentation] Analysis of Hox genes’ functions in craniofacial morphogenesis using recombinase mediated cassette exchange system that induces ectopic expression of Hox genes (2011)
  • Author(s): Taro Kitazawa
  • Organizer: 第44回日本発生生物学会年会
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県 宜野湾市）
• [Presentation] Collective endothelial cell movement in angiogenic morphogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: The 9th Japan-Korea Joint Symposium on vascular biology(招待講演)
  • Place of Presentation: ウエスティン朝鮮ホテル釜山(韓国)
• [Presentation] The first heart field subdomain defined by endothelin receptor type-A expression contributes to conduction system development (2011)
  • Author(s): Rieko Asai
  • Organizer: ESC Working Group on Developmental Anatomy and Pathology
  • Place of Presentation: リブリツェ･キャッスル（チェコ共和国）
• [Presentation] Id1 modulates sprouting angiogenesis possibly via spatiotemporal regulation of the Notch signal specification (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: 第84回日本生化学大会
  • Place of Presentation: 国立京都国際会館(京都府 京都市)
• [Presentation] エンドセリンシグナルによる咽頭弓動脈リモデリング機構の解明 (2011)
  • Author(s): 金 基成
  • Organizer: 第10回心臓血管発生研究会
  • Place of Presentation: ホテル華の湯（福島県 郡山市）
• [Presentation] Ex vivoにおける定量的血管新生評価系の開発 (2011)
  • Author(s): 西山 功一
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 栃木県総合文化センター（栃木県 宇都宮市）
• [Presentation] Dynamic and Heterogeneous collective endothelial cell movement driving angiogenic morphogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: The Second Pacific Symposium on Vascular Biology
  • Place of Presentation: 済州新羅ホテル（韓国）
• [Presentation] Morphogenetic cell movement in sprouting angiogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: 日蘭二国間交流セミナー Frontiers Angiogenesis: Development and Diseases(招待講演)
  • Place of Presentation: 昭和薬科大学（東京都 町田市）
• [Presentation] Novel roles of the Endothelin-1 and Endothelin A receptor signaling in coronary artery formation. (2011)
  • Author(s): Yuichiro Arima
  • Organizer: 日蘭二国間交流セミナー Frontiers Angiogenesis: Development and Diseases
  • Place of Presentation: 昭和薬科大学(東京都 町田市)
• [Presentation] Collective endothelial cell movement in angiogenic morphogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: オーランドコンベンションセンター（米国）
• [Presentation] Coronary artery anomalies in Endothelin-1 and Endothelin A receptor knockout mice. (2011)
  • Author(s): Yuichiro Arima
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: オーランドコンベンションセンター（米国）
• [Presentation] Mechanism involving dynamic and heterogeneous endothelial cell movement during angiogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: 第19回日本血管生物医学会学術集会(招待講演)
  • Place of Presentation: 東京ステーションコンファレンス （東京都 千代田区）
• [Presentation] Neural crest cells contribute to coronary artery development through endothelin signaling. (2011)
  • Author(s): Yuichiro Arima
  • Organizer: 第19回 日本血管生物医学会学術集会
  • Place of Presentation: 東京ステーションコンファレンス(東京 千代田区)
• [Presentation] Endothelin-1/Endothelin type-A receptor signaling regulates pharyngeal arch artery development through Dlx5/6-independent pathway. (2011)
  • Author(s): Ki-Sung Kim
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京ステーションコンファランス（東京都 千代田区）
• [Presentation] Angiogenic morphogenesis driven by collective endothelial cell behavior (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: 第34回分子生物学会年会(招待講演)
  • Place of Presentation: パシフィコ横浜（神奈川県 横浜市）
• [Presentation] 下顎形成におけるエンドセリンシグナルにおけるnon-coding RNAとパラスペックル蛋白の作用 (2011)
  • Author(s): 栗原 由紀子
  • Organizer: 第34回 日本分子生物学会
  • Place of Presentation: パシフィコ横浜（神奈川県 横浜市）
• [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis (2011)
  • Author(s): Taro Kitazawa
  • Organizer: 第34回 日本分子生物学会
  • Place of Presentation: パシフィコ横浜（神奈川県 横浜市）
• [Presentation] The first heart field subdomain defined by endothelin receptor type-A expression contributes to conduction system development (2011)
  • Author(s): Rieko Asai
  • Organizer: 第34回 日本分子生物学会
  • Place of Presentation: パシフィコ横浜（神奈川県 横浜市）
• [Presentation] Endothelin-1/ Endothelin A receptor signaling are required for proper coronary artery development. (2011)
  • Author(s): Yuichiro Arima
  • Organizer: 第34回 日本分子生物学会
  • Place of Presentation: パシフィコ横浜（神奈川県 横浜市）
• [Presentation] The neural crest contributes to coronary artery smooth muscle formation through endothelin signaling.
  • Author(s): Yuichiro Arima
  • Organizer: Weinstein Cardiovascular Development Conference 2012
  • Place of Presentation: シカゴ(アメリカ)
• [Presentation] 神経堤細胞によるエンドセリンシグナルを介した新規の冠動脈発生機構
  • Author(s): 有馬 勇一郎
  • Organizer: 第48回日本小児循環器学会総会・学術集会
  • Place of Presentation: 京都国際会議場（京都府京都市）
• [Presentation] 前耳胞神経堤細胞”Preotic neural crest”の冠動脈発生における寄与
  • Author(s): 有馬 勇一郎
  • Organizer: 第１１回日本心臓血管発生研究会
  • Place of Presentation: 磐梯熱海温泉 ホテル 華の湯（福島県 郡山市）
• [Presentation] The novel contribution of preotic neural crest cells in the coronary artery development
  • Author(s): 有馬 勇一郎
  • Organizer: AHA scientific session 2012
  • Place of Presentation: ロサンゼルス(アメリカ)
• [Presentation] Preotic neural crestはエンドセリンシグナリングを介して冠動脈平滑筋形成に寄与する
  • Author(s): 有馬 勇一郎
  • Organizer: 第16回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 東京大学本郷キャンパス
• [Presentation] Preotic neural crest cells contribute as a novel component of the coronary artery development
  • Author(s): 有馬 勇一郎
  • Organizer: 第20回日本血管生物医学会学術集会
  • Place of Presentation: あわぎんホール（徳島県徳島市）
• [Presentation] Preotic Neural Crest Cells Contribute to Coronary Artery Smooth Muscle Involving Endothelin Signaling
  • Author(s): 有馬 勇一郎
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
• [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis
  • Author(s): Taro Kitazawa
  • Organizer: 第45回日本発生生物学会 第64回細胞生物学会 合同大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
• [Presentation] Ectopic Hox gene expression in cranial neural crest cells results in abnormal craniofacial development revealing a possible Hox/Dlx crosstalk
  • Author(s): Taro Kitazawa
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡県福岡市）
• [Presentation] Involvement of non-coding RNA : Evf2 in the Endothelin signaling in branchial arch developmentInvolvement of non-coding RNA : Evf2 in the Endothelin signaling in branchial arch development
  • Author(s): Yukiko Kurihara
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡県福岡市）
• [Presentation] Involvement of non-coding RNA Evf2 in the endothelin signaling in branchial arch development
  • Author(s): Yukiko Kurihara
  • Organizer: Cell Synposia, Functional RNAs
  • Place of Presentation: Hotel Melia, Sitges（スペイン）
• [Presentation] Endothelin-1 regulates branchial arch morphogenesis by regulating integenic enhancer activity of Dlx5 and Dlx6 in mouse embryo
  • Author(s): 内島 泰信
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡県福岡市）
• [Presentation] A defensive role of Sirt3 against oxidative stress and aging in preimplantation embryos
  • Author(s): Yumiko Kawamura
  • Organizer: the 25th Annual Mouse Molecular Genetics Conference
  • Place of Presentation: Pacific Grove, CA（アメリカ）
• [Presentation] MicroRNA 199/214 cluster is required for normal growth and skeletal development in mice
  • Author(s): Yumiko Kawamura
  • Organizer: Cell Symposia; Functional RNAs
  • Place of Presentation: Hotel Melia, Sitges（スペイン）
• [Presentation] A protective role of Sirt3 against oxidative stress and aging in mouse preimplantation embryos
  • Author(s): Yumiko Kawamura
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡県福岡市）
• [Presentation] A novel mathematical model of angiogenic morphogenesis: implication of tip cell dynamics
  • Author(s): Kei Sugihara
  • Organizer: 第45回日本発生生物学会 第64回細胞生物学会 合同大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
• [Presentation] Analysis of cell-based mechanisms involved in angiogenic morphogenesis by biological and computational approaches
  • Author(s): Koichi Nishiyama
  • Organizer: 17th International Vascular Biology Meeting 2012
  • Place of Presentation: Rhein-Main-Hallen Wiesbaden（ドイツ）
• [Presentation] 血管構造をつくる血管内皮細胞動態の可視化と理解
  • Author(s): 西山 功一
  • Organizer: 第34回日本血栓止血学会学術集会
  • Place of Presentation: ハイアットリージェンシー東京
• [Presentation] 血管の形づくりを担う内皮細胞動態
  • Author(s): 西山 功一
  • Organizer: 第22回日本数理生物学会大会
  • Place of Presentation: 岡山大学津島キャンパス（岡山県岡山市）
• [Presentation] Cell-based mechanism behind angiogenic morphogenesis: analysis using both experimental and computational approaches
  • Author(s): Koichi Nishiyama
  • Organizer: 7th International Kloster Seeon Meeting ‘Angiogenesis’: Molecular Mechanisms and Functional Interactions
  • Place of Presentation: KLOSTER SEEON（ドイツ）
• [Presentation] Experimental and computational analysis underscores the importance of tip cell dynamics in angiogenic morphogenesis
  • Author(s): Koichi Nishiyama
  • Organizer: 第16回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 東京大学本郷キャンパス
• [Presentation] Imaging, quantification and modeling of self-organizing behaviors of vascular cells
  • Author(s): Koichi Nishiyama
  • Organizer: 第20回日本血管生物医学会学術集会
  • Place of Presentation: あわぎんホール（徳島県徳島市）
• [Presentation] A novel mathematical model of endothelial cell dynamics during angiogenic morphogenesis: analysis of cell-based mechanisms
  • Author(s): Kei Sugihara
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡県福岡市）
• [Presentation] Cell-based mechanism behind angiogenic morphogenesis
  • Author(s): Koichi Nishiyama
  • Organizer: The 23rd CDB meeting
  • Place of Presentation: 理化学研究所 発生再生科学総合研究センター（兵庫県神戸 市）
• [Presentation] 血管のかたちをつくる血管細胞動態の理解
  • Author(s): 西山 功一
  • Organizer: 第42回日本心脈管作動物質学会
  • Place of Presentation: 奈良県立新公会堂（奈良市）
• [Presentation] 心流入路におけるエンドセリンA型受容体発現細胞群は心室形成および刺激伝導系形成に寄与する
  • Author(s): 淺井 理恵子
  • Organizer: 第１１回日本心臓血管発生研究会
  • Place of Presentation: 磐梯熱海温泉 ホテル 華の湯（福島県 郡山市）
• [Presentation] Endothelin type A receptor expressing cell population in the inflow tract contributes to chamber formation and cardiac conduction system development
  • Author(s): 淺井 理恵子
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡県福岡市）
• [Presentation] Mouse-chick chimeric transplantation reveals the regional contribution of the cell population arising from the inflow tract to cardiac chamber formation
  • Author(s): Rieko Asai
  • Organizer: Weinstein Cardiovascular Development Conference 2012
  • Place of Presentation: シカゴ(アメリカ)
• [Remarks]
  • URL: http://bio.m.u-tokyo.ac.jp/
• [Remarks] 東京大学大学院医学系研究科代謝生理化学教室
  • URL: http://bio.m.u-tokyo.ac.jp/home-j.html
• [Remarks]
  • URL: http://bio.m.u-tokyo.ac.jp/home-j.html