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The transcriptional regulation of calcium induced cell death in heart

Research Project

Project/Area Number 23659110
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionOsaka University

Principal Investigator

NAKAYAMA Hiroyuki  大阪大学, 薬学研究科, 准教授 (40581062)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsカルシウム / 細胞死 / 転写因子 / 心不全
Research Abstract

Recent studies demonstrated that the osteopontin (OPN), an acid phosphoprotein plays pivotal roles in cardiac hypertrophy and failure. An osteogenic transcription factor Runx2 regulates the expression of OPN in osteoblasts. In the present study, we attempted to examine the pathological role of Runx2 in cardiac hypertrophy and failure. We generated transgenic mice (TG) overexpressing Runx2. Two TG lines (low and high) were obtained and high-expressing TG (HE-TG) showed cardiac hypertrophy and premature death within 8 weeks of age. In addition, HE-TG mice demonstrated decreased fractional shortening assessed by echocardiography. In response to pressure overload, low expressing TG (LE-TG) demonstrated higher mortality and enhanced cardiac hypertrophic response after TAC. In conclusion, targeted expression of Runx2 in heart mediates cardiac dysfunction and hypertrophy in mice. Thus, Runx2 could be a novel therapeutic target for heart failure.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2012 Other

All Presentation (4 results)

  • [Presentation] 心筋特異的 Runx2 過剰発現マウスは心肥大を惹起する2012

    • Author(s)
      濱谷辰斗、中山博之、松浪佐知、松尾玲男、藤尾慈
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2012-03-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Cardiac-specific overexpression of Runx2 mediates cardiac hypertrophy and dysfunction in mice2012

    • Author(s)
      中山 博之
    • Organizer
      American Heart Association Basic Cardiovascular Conference
    • Place of Presentation
      New Orleans
    • Related Report
      2012 Annual Research Report
  • [Presentation] 心筋Runx2過剰発現マウスは心肥大を惹起する2012

    • Author(s)
      濱谷辰斗
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Research-status Report
  • [Presentation] Cardiac-specific overexpression of Runx2 mediates cardiac hypertrophy and dysfunction in mice

    • Author(s)
      中山博之、濱谷辰斗、熊谷渉平、舎川洸太、山下朋美、藤尾慈
    • Organizer
      American Heart Association, Basic Cardiovascular Sciences 2012
    • Place of Presentation
      (New Orleans, USA
    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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