Elucidation of mechanism for production of causal factor of vasospasm
Project/Area Number |
23659113
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
General physiology
|
Research Institution | Yamaguchi University |
Principal Investigator |
KOBAYASHI Sei 山口大学, 医学(系)研究科(研究院), 教授 (80225515)
|
Co-Investigator(Kenkyū-buntansha) |
KISHI Hiroko 山口大学, 大学院医学系研究科, 准教授 (40359899)
|
Project Period (FY) |
2011-04-28 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 病態生理 / 血管攣縮 / 血管異常収縮 / 血管病 / 酸化ストレス / 活性酸素 |
Outline of Final Research Achievements |
The purpose of this study is to clarify the molecular mechanism of causal factor of vasospasm, SPC. Surprisingly, SPC was not produced by the enzymatic reaction, but by the non-enzymatic reaction. We discovered that OH radical plays an essential role of the non-enzymatic production of SPC.
|
Report
(5 results)
Research Products
(12 results)
-
[Journal Article] Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-12015
Author(s)
Yoshiteru Kagawa, Yuki Yasumoto, Kazem Sharifi, Majid Ebrahimi, Ariful Islam, Hirofumi Miyazaki, Yui Yamamoto, Tomoo Sawada, Hiroko Kishi, Sei Kobayashi, Motoko Maekawa, Takeo Yoshikawa, Eiichi Takaki Akira Nakai, Hiroshi Kogo, Toyoshi Fujimoto, Yuji Owada
-
Journal Title
Glia
Volume: 63
Pages: 780-794
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-