| Project/Area Number |
23659119
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Hokkaido University |
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Principal Investigator |
SONOYAMA Kei 北海道大学, 大学院・農学研究院, 准教授 (90241364)
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| Co-Investigator(Kenkyū-buntansha) |
TSUBOTA Toshio 北海道大学, 大学院・獣医学研究科, 教授 (10207441)
TAKIGUCHI Mitsuyoshi 北海道大学, 大学院・獣医学研究科, 教授 (70261336)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 冬眠 / 腸内細菌叢 / 腸粘膜バリア / 上皮細胞 / シリアンハムスター / 消化管 / ツキノワグマ |
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| Research Abstract |
This study investigated the control of gut microbiota and gut mucosal barrier in hibernating animals. In hibernating Syrian hamsters, we observed higher concentrations of secretory antibodies in the small intestinal contents, suggesting its contribution to protection against infection. Indeed, no bacteria were observed in the mesenteric lymph node of hibernating hamsters. Analysis of lymphocyte profiles in the immune tissues indicated that ability to protect against infection and to regulate immune function may be maintained in the gut of hibernating hamsters. Furthermore, we found that cell renewal of intestinal epithelium is markedly retarded in hibernating hamsters.
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